Haematology: Recent submissions
Now showing items 21-39 of 39
-
Molecular determinants of vitamin K-dependent protease signalling
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Haematology, 2013)In addition to facilitating fibrin clot formation, a growing body of evidence suggests that coagulation factors play an important role in regulating the innate immune response to infection. Vitamin K-dependent (VKD) proteases ... -
Investigations into Pyrrolo-1,5-Benzoxazepine-15-induced apoptosis of chronic B-cell malignancies
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Haematology, 2009)Multiple myeloma and chronic lymphocytic leukaemia (CLL) are chronic B-cell malignancies, which are characterised by the accumulation of malignant cells with low proliferative capacity and defective apoptotic mechanisms. ... -
Prostate cancer progression to androgen independence - do changes in the androgen receptor CAG repeat number play a role?
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Haematology, 2007)Prostate cancer is the commonest non-cutaneous male malignancy and is the second commonest cause of cancer-related deaths in many Western countries. Approximately half of all men diagnosed with prostate cancer will have ... -
Genetic analysis of the human prohibitin gene (PHB) in breast and other cancers
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Haematology, 2000)Prohibitin, an evolutionarily conserved gene situated on chromosome 17q21, was originally identified as a gene with antiproliferative properties. Studies of a Japanese population have shown prohibitin to be somatically ... -
The coagulation & inflammation interface : the pathophysiological basis for disease states
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Haematology, 2003)The molecular and cellular pathways of coagulation and inflammation have traditionally been regarded as separate entities, however recent research has demonstrated that they are closely linked through endothelial and ... -
Prognostic factors in chronic lymphocytic leukemia
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Haematology, 2008)Chronic lymphocytic leukaemia (CLL) is the most common leukaemia in the Western world, accounting for nearly 24% of all leukaemias. It is estimated that 7300 new cases were diagnosed in 2003 in the United States and there ... -
Drug-induced veno-occlusive disease of the liver : unravelling the role of the inflammatory and coagulation pathways
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Haematology, 2008)The thiopurines thioguanine (6TG) and mercaptopurine (6MP), along with Mylotarg (an antibody targeted agent), are used in the treatment of acute leukaemias. These drugs are more commonly associated with the development of ... -
Detection of minimal residual disease and WT1 overexpression in childhood acute leukaemia
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Haematology, 2008)Minimal residual disease (MRD), the post-treatment presence of a small submicroscopic amount of leukaemic cells in the bone marrow or other sites undetectable by conventional methods, has been recently shown to be one of ... -
The protein C pathway : linking inflammation and coagulation
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Haematology, 2000)Activated protein C (APC) is a natural anticoagulant and plays a pivotal role in coagulation homeostasis by inhibiting factors Villa and Va. Recent data suggests that APC also negatively regulates pro-inflammatory cytokine ... -
MicroRNA-497 increases apoptosis in MYCN amplified neuroblastoma cells by targeting the key cell cycle regulator WEE1.
(2013)Neuroblastoma is responsible for 15% of all childhood cancer deaths. Despite advances in treatment and disease management, the overall 5-year survival rates remain poor in high-risk disease (25-40%). MiR-497 was previously ... -
The microtubule targeting agent PBOX-15 inhibits integrin-mediated cell adhesion and induces apoptosis in acute lymphoblastic leukaemia cells
(2013)Although recent decades have seen an improved cure rate for newly diagnosed paediatric acute lymphoplastic leukemia (ALL), the treatment options for adult ALL, T-cell ALL (T-ALL) and relapsed disease remain poor. We have ... -
Quantification of unfractionated heparin in human plasma and whole blood by means of novel fluorogenic anti-FXa assays
(Elsevier, 2011)Novel and sensitive plate-based fluorogenic anti-factor Xa (FXa) assays were investigated to quantify unfractionated heparin (UFH) in human plasma and whole blood within the therapeutic ranges of 0-1.6 U/mL and 0?0.8 U/mL, ... -
Multifunctional specificity of the protein C/activated protein C Gla domain.
(American Society for Biochemistry and Molecular Biology, 2006)Activated protein C (APC) has potent anticoagulant and anti-inflammatory properties that are mediated in part by its interactions with its cofactor protein S and the endothelial cell protein C receptor (EPCR). The protein ... -
ADAMTS13 substrate recognition of von Willebrand factor A2 domain.
(2006)ADAMTS13 controls the multimeric size of circulating von Willebrand factor (VWF) by cleaving the Tyr1605?Met1606 bond in theA2 domain. To examine substrate recognition, we expressed in bacteria and purified three A2 ... -
Dissociation of activated protein C functions by elimination of protein S cofactor enhancement.
(2008)Activated protein C (APC) plays a critical anticoagulant role in vivo by inactivating procoagulant factor Va and factor VIIIa and thus down-regulating thrombin generation. In addition, APC bound to the endothelial cell ... -
Platelet factor 4 impairs the anticoagulant activity of activated protein C.
(2009)Platelet factor 4 (PF4) is an abundant platelet -granule chemokine released following platelet activation. PF4 interacts with thrombomodulin and the -carboxyglutamic acid (Gla) domain of protein C, thereby enhancing ... -
Severe Plasmodium falciparum malaria is associated with circulating ultra-large von Willebrand multimers and ADAMTS13 inhibition.
(2009)Plasmodium falciparum infection results in adhesion of infected erythrocytes to blood vessel endothelium, and acute endothelial cell activation, together with sequestration of platelets and leucocytes. We have previously ... -
A new microtubule-targeting compound PBOX-15 inhibits T-cell migration via post-translational modifications of tubulin.
(2008)The ordered, directional migration of T-lymphocytes is a key process during immune surveillance, immune response, and development. A novel series of pyrrolo-1,5-benzoxazepines have been shown to potently induce apoptosis ...
