Physiology: Recent submissions
Now showing items 1-20 of 246
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Optimising Electrode Montages in Conventional Transcranial Direct Current Stimulation and High-Definition Transcranial Direct Current Stimulation of the Cerebellum for Pain Modulation
(2025)The cerebellum is involved in pain processing and, therefore, an important target for non-invasive brain stimulation (NIBS) for analgesia. When targeting a brain region for NIBS, it can be difficult to ensure activation ... -
Investigating the influence of sex differences on modulation of neuroinflammation in the mouse by aerobic exercise
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2025)Exercise has long been viewed as an 'all-in-one' therapeutic approach by preserving and improving health and reducing the risk of age-associated noncommunicable metabolic, cardiovascular and neurodegenerative diseases ... -
Regional specific modulation of neuronal activation associated with the antidepressant-related properties of neuronal nitric oxide synthase (nNOS) inhibitors
(Trinity College (Dublin, Ireland). Department of Physiology, 2016)Depression is a significant health problem in today’s society and when left untreated can be a devastating illness. Current antidepressant treatments are far from ideal as several weeks are required for a therapeutic effect, ... -
Protective effects of noradrenergic and neurotrophic signalling on neuronal complexity in vitro
(Trinity College (Dublin, Ireland). Department of Physiology, 2016)Neuronal atrophy and synaptic dysfunction are prevalent features of a range of neurological disorders. Degeneration of neurites and loss of synaptic connections often precede cell loss during neurodegeneration and the ... -
Analysis of the metabolic shift that accompanies differential activation of microglia
(Trinity College (Dublin, Ireland). Department of Physiology, 2017)Microglia, the resident immune cells of the central nervous system (CNS), adopt different phenotypes upon activation by different stimuli. The primary role of microglia is protection and maintenance of homeostasis, and any ... -
Excercise and TrkB activation as neuroprotectants in mouse models of age and neuroinflammation : an assessment of underlying mechanisms
(Trinity College (Dublin, Ireland). Department of Physiology, 2017)The processes of learning and memory concern themselves primarily with the hippocampus - one of two exclusive cortical regions where neurogenesis has been found to take place. These cognitive processes are themselves ... -
Elucidating the therapeutic potential of Q8 in Glioblastoma Multiforme
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2024)Glioblastoma multiforme (GBM) is the most common and aggressive form of brain cancer in humans. Despite advancements in treatment and care, patient outcomes and survival rates are abysmal, with a five-year survival rate ... -
Examining short interval intracortical inhibition with different transcranial magnetic stimulation-induced current directions in ALS
(2024)Objective: To establish if induced current direction across the motor cortex alters the sensitivity of transcranial magnetic stimulation (TMS)-evoked short-interval intracortical inhibition (SICI) as an ALS biomarker. Methods: ... -
Investigating the Immune System in Parkinson's Disease
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2024)In 1817 James Parkinson first described the symptoms of the Parkinson's disease (PD). It is the second most common neurodegenerative disease worldwide, and cases are rising exponentially. Characteristic hallmarks of PD ... -
Investigating the therapeutic utility of Olaparib in Metachromatic Leukodystrophy and Krabbe Disease
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2024)Leukodystrophies encompass a diverse group of genetically-based disorders that impact the development and preservation of myelin in the central nervous system's white matter. These conditions, affecting approximately 1 in ... -
The Impact and Influence of Sports Related Concussion and Cardiovascular Risk Factors on Brain and Heart Health across an Ageing Population
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2023)This study focused on the relationship between perceptual performance, brain health, and cardiovascular (CV) profiles in both recreational athletes and non-athletes, bridging the gap between sensory integration, cognitive ... -
Identifying the therapeutic potential of novel compounds in the treatment of Glioblastoma Multiforme
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2023)Glioblastoma multiforme (GBM) is the most common and aggressive brain cancer in adults with a dismal 5-year survival rate of <5%. Despite advanced diagnostic and multimodal treatments including surgery, followed by ... -
Antipsychotics Prevent Psychosine Induced Toxicity in Glial Cells.
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2023)Glial cells are implicated in the neuropathophysiology of schizophrenia and other neuropsychiatric disorders. Also, the role of altered myelin in the onset and development of schizophrenia and changes in myelin due to ... -
Low-volume HIIT and MICT speed VO2 kinetics during high-intensity "work-to-work" cycling with a similar time-course in type 2 diabetes
(2022)We assessed the rates of adjustment in oxygen uptake (V̇o2) and muscle deoxygenation [i.e., deoxygenated hemoglobin and myoglobin, (HHb + Mb)] during the on-transition to high-intensity cycling initiated from an elevated ... -
Priming exercise accelerates oxygen uptake kinetics during high-intensity cycle exercise in middle-aged individuals with type 2 diabetes
(2022)Background: The primary phase time constant of pulmonary oxygen uptake kinetics ( ⋅VO2 τ p) during submaximal efforts is longer in middle-aged people with type 2 diabetes (T2D), partly due to limitations in oxygen supply ... -
Exploring Sex-Related Differences in Microglia May Be a Game-Changer in Precision Medicine
(2022)One area of microglial biology that has been relatively neglected until recently is sex differences and this is in spite of the fact that sex is a risk factor in several diseases that are characterized by neuroinflammation ... -
Central and peripheral characterisation of TLR7/8 and endocannabinoid signalling in multiple sclerosis
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2022)Toll-like receptors (TLRs) are a class of pattern-recognition receptors (PRRs) involved in initiating an immune response to infection or endogenous damage. These receptors are expressed on cells of both the innate and ... -
Effects on an acute priming exercise and high-intensity interval training on oxygen uptake and muscle deoxygenation kinetics in older individuals with type 2 diabetes
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2021)Peak oxygen uptake (V̇O2peak) is consistently reduced in individuals with type 2 diabetes (T2D) of all ages compared with non-diabetic (ND) controls. In middle-aged (between 45 to 60 y) individuals with T2D these reductions ... -
Elucidating the complex organization of neural micro-domains in the locust Schistocerca gregaria using dMRI
(2021)To understand brain function it is necessary to characterize both the underlying structural connectivity between neurons and the physiological integrity of these connections. Previous research exploring insect brain ... -
From Mechanisms to Analgesia: Towards the Use of Non-Invasive Neuromodulation for Pain Relief in the Clinic
(Intech Open, 2020)The use of electricity for analgesic effects has a long history and yet currently neuromodulation devices based on electrical stimulation are typically restricted to being a last resort intervention for pain patients after ...
