Physiology: Recent submissions
Now showing items 41-60 of 246
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Design and synthesis of selective and potent orally active S1P5 agonists.
(2010)The immunomodulatory drug fingolimod (FTY720, 2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol), derived from a fungal metabolite (ISP-1, myriocin), is phosphorylated in vivo by sphingosine kinases to produce ... -
Amyloid precursor protein knockdown by siRNA impairs spontaneous alternation in adult mice.
(2007)The cleavage-product of amyloid precursor protein (APP) constitutes the core component of plaques found in the brains of Alzheimer's disease (AD) patients. APP is ubiquitously expressed and its precise physiological functions ... -
Consensus analysis of Signal Peptide Peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared to Presenilins
(2004)The human genome encodes seven intramembrane-cleaving GXGD aspartic proteases. These are the two presenilins that activate signaling molecules and are implicated in Alzheimer's disease, signal peptide peptidase (SPP), ... -
The PDZ Domain of PICK1 Differentially Accepts Protein Kinase C-α and GluR2 as Interacting Ligands
(2004)The C terminus (ct) of protein kinase C-α (PKCα) has a type I PDZ binding motif, whereas GluR2 has a type II PDZ binding motif. Both motifs are recognized by the PDZ domain of protein interacting with protein kinase C ... -
Functional expression of serotonin 5-HT7 receptor in human glioblastoma cell lines
(2004)Serotonin 5‐HT7 receptors are present in astrocytes. Understanding their role in this type of cell would greatly benefit from the identification of astroglial cell lines expressing this receptor type. The aim of the present ... -
Regulation of synaptic strength & AMPA receptor subunit composition by PICK1
(2004)PICK1 (protein interacting with C kinase-1) regulates the surface expression of the AMPA receptor (AMPAR) GluR2 subunit, however,the functional consequences of this interaction are not well understood. Previous work has ... -
The cellular protein level of Parkin is regulated by its ubiquitin-like domain
(2003)Parkin is a ubiquitin-protein isopeptide ligase (E3) involved in ubiquitin/proteasome-mediated protein degradation. Mutations in the parkin gene cause a loss-of-function and/or alter protein levels of parkin. As a result, ... -
The PDZ Proteins PICK1, GRIP and Syntenin bind multiple glutamate receptor subtypes
(2002)Using sequence homology searches, yeast two-hybrid assays and glutathione S-transferase (GST)-pull-down approaches we have identified a series of glutamate receptor subunits that interact differentially with the PDZ proteins ... -
Rapid and differential regulation of AMPA and kainite receptors at hippocampal mossy fibre synapses by PICK1 and GRIP
(2003)We identified four PDZ domain-containing proteins, syntenin, PICK1, GRIP, and PSD95, as interactors with the kainate receptor (KAR) subunits GluR52b, GluR52c, and GluR6. Of these, we show that both GRIP and PICK1 interactions ... -
PDZ Proteins interacting with c-terminal GluR2/3 are involved in a PKC-dependent regulation of AMPA receptors at hippocampal synapses
(2000)We investigated the role of PDZ proteins (GRIP, ABP, and PICK1) interacting with the C-terminal GluR2 by infusing a ct-GluR2 peptide (“pep2-SVKI”) into CA1 pyramidal neurons in hippocampal slices using whole-cell recordings. ... -
Inhibition of the Interaction Between Group I Metabotropic Glutamate Receptors and PDZ-Domain Proteins Prevents Hippocampal Long-Term Depression, but Not Long-Term Potentiation
(2019)The group I metabotropic glutamate (mGlu) receptor subtypes, mGlu1 and mGlu5, strongly regulate hippocampal synaptic plasticity. Both harbor PSD-95/discs-large/ZO-1 (PDZ) motifs at their extreme carboxyl terminals, which ... -
Effects of high -intensity interval vs moderate-intensity continous training on the time course adapations in cardiovascular fitness and oxygen uptake kinetics in type 2 diabetes
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2019)Individuals with type 2 diabetes mellitus (T2DM) present with significant impairments in the dynamic and peak responses of pulmonary oxygen uptake (V̇O2) during exercise. Both low-volume high-intensity interval training ... -
Influence of hormonal status, ageing and smoking on autonomic cardiovascular control and endothelial function
(Trinity College (Dublin, Ireland). Department of Physiology, 2004)Ageing, hypertension and smoking are known risk factors for cardiovascular disease. By contrast female sex hormones are known to have cardioprotective qualities ; however, their underlying mechanisms of action have yet to ... -
Effects of acute and chronic exercise on autonomic cardiovascular control and endothelial function in young and older healthy male subjects
(Trinity College (Dublin, Ireland). Department of Physiology, 2002)Exercise training is known to reduce resting blood pressure ; however, the underlying mechanisms have yet to be fully elucidated. The main objective of this thesis was to investigate the effects of exercise in two parameters ... -
Characterisation of LTP induced by multiple spaced 200 Hz protocol in the rat dentate gyrus in vitro
(Trinity College (Dublin, Ireland). Department of Physiology, 2004)Long-term potentiation (LTP) in the hippocampus is believed to be a cellular correlate of learning and memory in the mammalian brain. Four different highfrequency stimulation (HFS) protocols were developed which induced ... -
A role for IL-1B in oxidative stress-mediated neuronal impairment
(Trinity College (Dublin, Ireland). Department of Physiology, 2000)The aims of this study were to; (1) investigate age-related changes in the antioxidant defence system in the rat cortex and hippocampus; (2) investigate the role of IL-1β in influencing oxidative stress in brain tissue of ... -
An investigation into the roles played by interleukin-1Beta and reactive oxygen species in the rat brain during ageing
(Trinity College (Dublin, Ireland). Department of Physiology, 2002)Ageing is associated with an increase in reactive oxygen species production and an increase in the concentration of the pro-inflammatory cytokine interleukin-1β in the hippocampus. These have both been shown to have ... -
The effects of group II mGluR agonists on short-term depression and neutral coding in the rat dentate gyrus in vitro
(Trinity College (Dublin, Ireland). Department of Physiology, 2000)Short-term depression is an activity-dependent reduction in synaptic efficacy which has been observed at a wide variety of synapses in the CNS, and is often attributed to a depletion of the available store of neurotransmitter. ... -
Mechanism of inhibition of LTP induction by preconditioning stimulation in the rat dentate gyrus in vitro
(Trinity College (Dublin, Ireland). Department of Physiology, 2003)The modulation of synaptic plasticity (LTP) by prior synaptic activity represented by preconditioning stimulation (weak HFS) was investigated in the medial perforant pathway of the dentate gyrus in vitro. The inhibition ... -
Endothelial physiology in young cigareete smokers : a multifunctional analysis of the effect of taurine supplementation
(Trinity College (Dublin, Ireland). Department of Physiology, 2000)The aim of this thesis is to determine the impact of cigarette smoking on endothelial dependent integration of the cardiovascular haemodynamic and barrier functions. Considering the antioxidant, anti-inflammatory and ...
