Physiology: Recent submissions
Now showing items 81-100 of 246
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Eye-Hand Coordination: Dextrous Object Manipulation in New Gravity
(ESA Publications Division, 2005) -
An Investigation of Inflammatory and Metabolic Blood-Based Biomarkers of Cognitive Decline
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2018)Alzheimer’s disease (AD) and other dementias a re the main cause of cognitive impairment in older adults. AD is fast becoming a global epidemic, yet the development of a ... -
Pulmonary oxygen uptake and muscle deoxygenation responses during ramp incremental exercise and moderate- and heavy-intensity exercise subsequent to priming exercise in type 2 diabetes.
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2017)Middle-aged and young individuals with uncomplicated type 2 diabetes mellitus (T2DM) consistently demonstrate impairments in submaximal and maximal exercise performance, which are independent of obesity, and present in the ... -
The signalling and function of EB12 in the central nervous system
(Trinity College (Dublin, Ireland). Department of Physiology, 2014)The four major brain-specific cell types in the brain are; (i) neurons, which transmit and process information via electrical signals, (ii) oligodendrocytes, which insulate neuronal axons with fatty sheets called myelin ... -
The modulation of S1P receptor signalling and demyelination
(Trinity College (Dublin, Ireland). Department of Physiology, 2014)Sphingosine 1-phosphate receptors are a family of G-protein coupled receptors (GPCRs) that consists of five subtypes (S1PR1-5). These receptors have emerged as therapeutic targets in multiple sclerosis (MS) due to the ... -
Interactions between endocannabinoids and neurotrophins in adult neurogenesis : implications for spatial memory
(Trinity College (Dublin, Ireland). Department of Physiology, 2014)The cellular mechanisms underlying learning and memory have yet to be fully elucidated. Over the past fifteen years there has been a dramatic increase in the study of adult neurogenesis; a process in which neurons are ... -
Investigating the role of inflammation in schizophrenia
(Trinity College (Dublin, Ireland). Department of Physiology, 2013)Schizophrenia is a psychiatric illness that has more recently been described as a neurodevelopment disorder. The cause of this disorder is currently unknown and likely involves both genetic and environmental factors. Several ... -
Rodent models of immunologically induced-depression and anxiety related behaviour and associated biomarkers
(Trinity College (Dublin, Ireland). Department of Physiology, 2014)A series of rodent animal models of immune activation were assessed to develop an understanding of interactions between the immune system and brain leading to changes in behaviour and the determination of biomarkers of ... -
Neuroimmune activation in arthritic and neuropathic low back pain : implications for interventional therapies
(Trinity College (Dublin, Ireland). Department of Physiology, 2014)Chronic pain involves a progressive disturbance of mood, sleep and physical function, with significant medical, social and economic consequences. The mechanism by which acute pain may become chronic and refractory to ... -
Sleep Spindles as Facilitators of Memory Formation and Learning
(2016)Over the past decades important progress has been made in understanding the mechanisms of sleep spindle generation. At the same time a physiological role of sleep spindles is starting to be revealed. Behavioural studies ... -
Fractalkine shedding is mediated by p38 and the ADAM10 protease under pro-inflammatory conditions in human astrocytes
(2016)Check TCD e-journals(opens in a new window)|View at Publisher| RIS export | Download | Add to List | More... Journal of Neuroinflammation Volume 13, Issue 1, February 08, 2016, Article number 31 Open ... -
The EBI2 signalling pathway plays a role in cellular crosstalk between astrocytes and macrophages
(2016)EBI2 is a G protein-coupled receptor activated by oxysterol 7α, 25-dihydroxycholesterol (7α25HC) and regulates T cell-dependant antibody response and B cell migration. We recently found EBI2 is expressed in human astrocytes, ... -
The dual S1PR1/S1PR5 drug BAF312 (Siponimod) attenuates demyelination in organotypic slice cultures
(2016)Background BAF312 (Siponimod) is a dual agonist at the sphingosine-1 phosphate receptors, S1PR1 and S1PR5. This drug is currently undergoing clinical trials for the treatment of secondary progressive multiple sclerosis ... -
An investigation of oxidative stress in skeletal muscle
(Trinity College (Dublin, Ireland). Department of Physiology, 2005)Reactive oxygen species (ROS) are produced as a by-product of oxidative phosphorylation in mitochondria and via various cellular enzyme systems. ROS production is buffered by cellular antioxidant defences, which include ... -
Beta₂-adrenoceptors as modulators of glial immune function
(Trinity College (Dublin, Ireland). Department of Physiology, 2009)The endogenous anti-inflammatory and neurotrophic effects of noradrenahne are mediated by β2-adrenoceptors on astrocytes and microglia in the central nervous system (CNS). Notably, clinical studies demonstrate that ...
