Browsing Clinical Microbiology by Title
Now showing items 1-20 of 63
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A role for proteases and transcriptional regulation in the expression of ClfB on the surface of staphylococcus aureus
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Microbiology, 2002)Staphylococcus aureus is an important human pathogen. This bacterium expresses proteins on its surface capable of binding to many host ligands including fibrinogen, fibronectin, collagen, elastin and von Willebrand factor. ... -
Analysis and development of the recombinant Semliki Forest virus vector as a cancer gene therapy agent
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Microbiology, 2001)Increased understanding of the molecular pathogenesis of cancer has shown that its accumulation is the result of multiple genetic alterations. Cancer is a disease of altered genes, with the most predominantly altered ... -
Anti-infective strategies in Pseudomonas aeruginosa biofilm formation
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Microbiology, 2014)P. aeruginosa infection is one of the main causes of lung function decline in patients with cystic fibrosis (CF). P. aeruginosa is associated with biofilm formation which can increase the rate of resistance to antibiotic ... -
Antimicrobial resistance and virulence in Escherichia coli bloodstream isolates : a phenotypic, genetic and genomic perspective
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Microbiology, 2010)Extraintestinal pathogenic Escherichia coli (ExPEC) are a major cause of sepsis, with a high associated mortality. They are widely reported to be the most frequent Gram-negative bacterial pathogen recovered from bacteraemia ... -
Antimicrobial resistance in clinical isolates of Pseudomonas aeruginosa
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Microbiology, 2011)Pseudomonas aeruginosa is one of the most feared Gram-negative bacterial pathogens. It is not only among the most frequently isolated Gram-negative organisms in bloodstream and wound infections, pneumonia, intra-abdominal-sepis ... -
Bacterial self-defence: how Escherichia coli evades serum killing.
(2014)The ability to survive the bactericidal action of serum is advantageous to extraintestinal pathogenic Escherichia coli that gain access to the bloodstream. Evasion of the innate defences present in serum, including complement ... -
Cell Survival and Cytokine Release after Inflammasome Activation Is Regulated by the Toll-IL-1R Protein SARM
(2019)Assembly of inflammasomes after infection or injury leads to the release of interleukin-1β (IL-1β) and to pyroptosis. After inflammasome activation, cells either pyroptose or enter a hyperactivated state defined by IL-1β ... -
Characterisation and Molecular Epidemiology of Mycobacterium chimaera isolates in Ireland
(Trinity College Dublin. School of Medicine. Discipline of Clinical Microbiology, 2019)Mycobacterium chimaera is a slow-growing nontuberculous Mycobacterium spp. that is now recognized as a separate species within the Mycobacterium avium Complex (MAC). In the past, M. chimaera was mainly associated with ... -
Characterisation of the Elastin Binding Protein (EbpS) of Staphylococcus aureus
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Microbiology, 2001)Staphylococcus aureus expresses an array of surface proteins that promote interaction of the bacterium with the host. Some surface proteins promote binding to components of the host extracellular matrix and can act as ... -
A commensal gone bad: complete genome sequence of the prototypical enterotoxigenic Escherichia coli strain H10407.
(American Society for Microbiology, 2010)In most cases, Escherichia coli exists as a harmless commensal organism, but it may on occasion cause intestinal and/or extraintestinal disease. Enterotoxigenic E. coli (ETEC) is the predominant cause of E. coli-mediated ... -
Comparison of two DNA microarrays for detection of plasmid-mediated antimicrobial resistance and virulence factor genes in clinical isolates of Enterobacteriaceae and non-Enterobacteriaceae
(2010)A DNA microarray was developed to detect plasmid-mediated antimicrobial resistance (AR) and viru- lence factor (VF) genes in clinical isolates of Enterobacteriaceae and non-Enterobacteriaceae. The array was validated with ... -
Development of a New Genome-Wide MLST Scheme for High-Resolution Typing of Diverse Mycobacterium tuberculosis Complex Strains
(2018)In this issue of EBioMedicine, Kohl and colleagues describe the development of a new core genome MLST scheme (cgMLST) for Mycobacterium tuberculosis complex strains based on a set of 2891 genes. Here, the application of ... -
Development of the recombinant Semliki Forest virus vector as a gene therapy agent for the central nervous system
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Microbiology, 2004)Multiple sclerosis (MS) is a neurological disease of the central nervous system (CNS), and a major cause of disability in young adults. It is characterized by the presence of inflammatory infiltrates containing autoreactive ... -
Diverse Roles for the Extracellular Glycome of Extra-intestinal Pathogenic Escherichia coli in Serum Resistance and more
(Trinity College Dublin. School of Medicine. Discipline of Clinical Microbiology, 2023)Extra-intestinal pathogenic Escherichia coli (ExPEC) is a major cause of urinary tract infections, bacteraemia, and sepsis. This laboratory, among others, has previously shown that prototypic urosepsis strain CFT073 is ... -
Does upregulated host cell receptor expression provide a link between bacterial adhesion and chronic respiratory disease?
(2016)Abstract Expression of the platelet-activating factor receptor is upregulated in the respiratory epithelium of smokers and chronic obstructive pulmonary disease patients. We have recently determined that increased ... -
Draft Genome Sequence of a Drug-Susceptible New Zealand Isolate of Mycobacterium tuberculosis Lineage 3.
(2014)Multidrug resistance constitutes a threat worldwide to the management of tuberculosis (TB). We report the draft whole-genome sequence of a lineage 3 (East-African Indian) isolate of Mycobacterium tuberculosis which presented ... -
Draft Genome Sequence of a Multidrug-Resistant New Zealand Isolate of Mycobacterium tuberculosis Lineage 3.
(2014)Multidrug resistance constitutes a threat worldwide to the management of tuberculosis (TB). We report the draft whole-genome sequence of a lineage 3 (East-African Indian) isolate of Mycobacterium tuberculosis which presented ...
