Psychiatry: Recent submissions
Now showing items 241-260 of 438
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Recruitment of the left hemispheric emotional attention neural network in risk for and protection from depression.
(2013)BACKGROUND: Family history of major depressive disorder (MDD) increases individuals' vulnerability to depression and alters the way depression manifests itself. Emotion processing and attention shifting are functions ... -
Implementing a court diversion and liaison scheme in a remand prison by systematic screening of new receptions: a 6 year participatory action research study of 20,084 consecutive male remands.
(2013)BACKGROUND: A mental health needs assessment in the Irish prison population confirmed findings from other jurisdictions showing high prevalence of severe mental illness, including psychosis amongst those newly committed. ... -
Prospective study of factors influencing conditional discharge from a forensic hospital: the DUNDRUM-3 programme completion and DUNDRUM-4 recovery structured professional judgement instruments and risk
(2013)Background We set out to examine whether structured professional judgement instruments DUNDRUM-3 programme completion (D-3) and DUNDRUM-4 recovery (D-4) scales along with measures of risk, mental state and global function ... -
Duplications in RB1CC1 are associated with schizophrenia; identification in large European sample sets
(Nature Publishing Group, 2013)Schizophrenia (SCZ) is a severe and debilitating neuropsychiatric disorder with an estimated heritability of ~80%. Recently, de novo mutations, identified by next-generation sequencing (NGS) technology, have been suggested ... -
Susceptibility (risk and protective) factors for in-patient violence and self-harm: Prospective study of structured professional judgement instruments START and SAPROF, DUNDRUM-3 and DUNDRUM-4 in forensic mental health services
(2013)Background The START and SAPROF are newly developed fourth generation structured professional judgement instruments assessing strengths and protective factors. The DUNDRUM-3 and DUNDRUM-4 also measure positive factors, ... -
Sodium-23 Magnetic Resonance Imaging has potential for improving penumbra detection but not for estimating stroke onset time
(2014)Tissue sodium concentration increases in irreversibly damaged (core) tissue following ischemic stroke and can potentially help to differentiate the core from the adjacent hypoperfused but viable penumbra. To test this, ... -
Schizophrenia at a genetics crossroads: Where to now?
(2013)These are interesting times for schizophrenia genetics. The last 5 years has seen unprecedented progress, moving us from debate about putative genetic models to an understanding that susceptibility involves a complex ... -
Relapse following successful electroconvulsive therapy for major depression: A meta-analysis
(2013)High rates of early relapse following electroconvulsive therapy (ECT) are typically reported in the literature. Current treatment guidelines offer little information to clinicians on the optimal nature of maintenance therapy ... -
A novel approach of homozygous haplotype sharing identifies candidate genes in autism spectrum disorder.
(2012)Autism spectrum disorder (ASD) is a highly heritable disorder of complex and heterogeneous aetiology. It is primarily characterized by altered cognitive ability including impaired language and communication skills and ... -
Mental health problems in children with prader-willi syndrome.
(2012)BACKGROUND: Prader-Willi Syndrome (PWS) is a genetically determined neurodevelopmental disorder, which occurs in approximately one in 22000 births. AIMS: This study aimed to investigate psychiatric characteristics of ... -
Individual common variants exert weak effects on the risk for autism spectrum disorderspi.
(2012)While it is apparent that rare variation can play an important role in the genetic architecture of autism spectrum disorders (ASDs), the contribution of common variation to the risk of developing ASD is less clear. To ... -
Abnormal functional connectivity in autism spectrum disorder is associated with disrupted white matter microstructural organisation
(2013)Disruption of structural and functional neural connectivity has been widely reported in Autism Spectrum Disorder (ASD) but there is a striking lack of research attempting to integrate analysis of functional and structural ... -
Abnormal functional connectivity during visuospatial processing is associated with disrupted organisation of white matter in autism.
(2013)Disruption of structural and functional neural connectivity has been widely reported in Autism Spectrum Disorder (ASD) but there is a striking lack of research attempting to integrate analysis of functional and structural ... -
Evidence that duplications of 22q11.2 protect against schizophrenia.
(2014)A number of large, rare copy number variants (CNVs) are deleterious for neurodevelopmental disorders, but large, rare, protective CNVs have not been reported for such phenotypes. Here we show in a CNV analysis of 47 005 ... -
Convergence of Genes and Cellular Pathways Dysregulated in Autism Spectrum Disorders
(2014)Rare copy-number variation (CNV) is an important source of risk for autism spectrum disorders (ASDs). We analyzed 2,446 ASD-affected families and confirmed an excess of genic deletions and duplications in affected versus ... -
Effect of Angiotensin II and Small GTPase Ras Signaling Pathway Inhibition on Early Renal Changes in a Murine Model of Obstructive Nephropathy
(2014)Tubulointerstitial fibrosis is a major feature of chronic kidney disease. Unilateral ureteral obstruction (UUO) in rodents leads to the development of renal tubulointerstitial fibrosis consistent with histopathological ... -
Depth-Dependent Differences in Community Structure of the Human Colonic Microbiota in Health
(2013)Objective The aims of this study were to develop techniques for spatial microbial assessment in humans and to establish colonic luminal and mucosal spatial ecology, encompassing longitudinal and cross-sectional ...
