Psychiatry: Recent submissions
Now showing items 281-300 of 438
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Analysis of the hexanucleotide repeat expansion and founder haplotype at C9ORF72 in an Irish psychosis case-control sample.
(2014)The hexonucleotide repeat expansion 'GGGGCC' at the C9ORF72 gene has been strongly linked with amyotrophic lateral sclerosis and frontotemporal dementia. There is some evidence for clinical and genetic overlap between ... -
Genomewide Association Scan of Suicidal Thoughts and Behaviour in Major Depression
(2011)Background: Suicidal behaviour can be conceptualised as a continuum from suicidal ideation, to suicidal attempts to completed suicide. In this study we identify genes contributing to suicidal behaviour in the depression ... -
Geonome-wide linkage analysis of 972 bipolar pedigrees using single-nucleotide polymorphisms
(2011)Because of the high costs associated with ascertainment of families, most linkage studies of Bipolar I disorder (BPI) have used relatively small samples. Moreover, the genetic information content reported in most studies ... -
The impact of study design and diagnostic approach in a larege multi-centre ADHD study. Part 1: ADHD Symptom patterns.
(2011)Background The International Multi-centre ADHD Genetics (IMAGE) project with 11 participating centres from 7 European countries and Israel has collected a large behavioural and genetic database for present and future ... -
No evidence that runs of homozygosity are associated with schizophrenia in an Irish genome-wide association dataset
(2014)Runs of homozygosity (ROH), regions of the genome containing many consecutive homozygous SNPs, may represent two copies of a haplotype inherited from a common ancestor. A rare variant on this haplotype could thus be present ... -
Common variant at 16p11.2 conferring risk of psychosis
(2012)Epidemiological and genetic data support the notion that schizophrenia and bipolar disorder share genetic risk factors. In our previous genome-wide association study, meta-analysis and follow-up (totaling as many as 18?206 ... -
Identification of common variants associated with human hippocampal and intracranial volumes
(2012)Identifying genetic variants influencing human brain structures may reveal new biological mechanisms underlying cognition and neuropsychiatric illness. The volume of the hippocampus is a biomarker of incipient Alzheimer's ... -
Gene-ontology enrichment analysis in two independent family-based samples highlights biologically plausible processes for autism spectrum disorders.
(2011)Recent genome-wide association studies (GWAS) have implicated a range of genes from discrete biological pathways in the aetiology of autism. However, despite the strong influence of genetic factors, association studies ... -
Category fluency, latent semantic analysis and schizophrenia: a candidate gene approach
(2014)Background Category fluency is a widely used task that relies on multiple neurocognitive processes and is a sensitive assay of cortical dysfunction, including in schizophrenia. The test requires naming of as many words ...
