School of Medicine: Recent submissions
Now showing items 141-160 of 3444
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Data driven subclassification of ANCA associated vasculitis: model-based clustering of the FAIRVASC cohort
(2024)Background: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis is a heterogenous autoimmune disease. While traditionally stratified into two conditions, granulomatosis with polyangiitis (GPA) and microscopic ... -
Ontology-based integration and querying of heterogeneous rare disease data sources - POLVAS perspective
(2025)The integration of rare disease medical databases belonging to different countries is an important problem, as a large number of observations are required for reliable statistical inference of patient data in order to ... -
Data quality and patient characteristics in European ANCA-associated vasculitis registries: data retrieval by federated querying
(2024)Objectives: This study aims to describe the data structure and harmonisation process, explore data quality and define characteristics, treatment, and outcomes of patients across six federated antineutrophil cytoplasmic ... -
Effect of Immunosuppression on the Immune Response to SARS-CoV-2 Infection and Vaccination.
(2024)Immunosuppressive treatment in patients with rheumatic diseases can maintain disease remission but also increase risk of infection. Their response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination ... -
Emergence of dysfunctional neutrophils with a defect in arginase-1 release in severe COVID-19
(2024)Neutrophilia occurs in patients infected with SARS-CoV-2 (COVID-19) and is predictive of poor outcomes. Here, we link heterogenous neutrophil populations to disease severity in COVID-19. We identified neutrophils with ... -
Translating Frailty Assessment Methodologies and Research-based Evidence to Clinical Education and Practice.
(2022)Frailty is a common clinical syndrome that predisposes older adults to an increased risk of adverse health outcomes. With population aging, this will become an increasing challenge for the healthcare services; therefore, ... -
Brain connectivity in frailty: insights from The Irish Longitudinal Study on Ageing (TILDA)
(2023)Frailty in older adults is associated with greater risk of cognitive decline. Brain connectivity insights could help understand the association, but studies are lacking. We applied connectome-based predictive modelling ... -
The 'Bermuda Triangle' of orthostatic hypotension, cognitive impairment and reduced mobility: prospective associations with falls and fractures in The Irish Longitudinal Study on Ageing.
(2023)Background: Orthostatic hypotension (OH), cognitive impairment (Cog) and mobility impairment (MI) frequently co- occur in older adults who fall. This study examines clustering of these three geriatric syndromes and ... -
Low vitamin B 12 but not folate is associated with incident depressive symptoms in community-dwelling older adults: a 4-year longitudinal study
(2021)This was a longitudinal study utilising the Irish Longitudinal Study on Ageing (n 3849 aged ≥ 50 years) and investigated the relationship between blood plasma folate and B 12 levels at baseline (wave 1) and incident ... -
Patterns in health service utilisation: Results from Wave 5 of The Irish Longitudinal Study on Ageing
(2020)The purpose of this report is to examine social and health care service utilisation among older adults in the latest available wave (i.e. Wave 5) of The Irish Longitudinal Study on Ageing (TILDA) – both community and ... -
Sleep duration, sleep problems and perceived stress are associated with hippocampal subfield volumes in later life: Findings from The Irish Longitudinal Study on Ageing (TILDA).
(2021)Study Objectives: This study examines the cross-sectional and 2-year follow-up relationships between sleep and stress and total hippocampal volume and hippocampal subfield volumes among older adults. Methods: Four hundred ... -
Orthostatic blood pressure variability is associated with lower visual contrast sensitivity function: Findings from the Irish Longitudinal Study on Aging.
(2019)Background: Hypertension is established to cause vascular end-organ damage. Other forms of dysregulated blood pressure (BP) behaviour, such as orthostatic hypotension have also been associated with cardiovascular (CV) events. ... -
Orthostatic hypertension as a risk factor for age-related macular degeneration: Evidence from the Irish longitudinal study on ageing.
(2018)Purpose: Age related macular degeneration (AMD) is a leading cause of irreversible visual loss in developed countries. It is associated with vascular risk factors including hypertension. Dysregulated blood pressure ... -
Comparisons of disease cluster patterns, prevalence and health factors in the USA, Canada, England and Ireland.
(2021)Background: Identification of those who are most at risk of developing specific patterns of disease across different populations is required for directing public health policy. Here, we contrast prevalence and patterns ... -
IFN-gamma-induced trained immunity as a strategy to enhance anti-microbial responses in human monocytes and macrophages.
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2025)Infectious diseases remain a significant global health threat, exacerbated by the rise in multi-drug- resistant infections and the potential for epidemics. Mycobacterium tuberculosis (M.tb) and Staphylococcus aureus are ... -
High-risk categories for COVID-19 and their distribution by county in Republic of Ireland-evidence from the TILDA study
(2020)Older persons and those with pre-existing chronic conditions are most likely to experience severe consequences from COVID-19. Because immune defences decline and chronic diseases rise with age, people aged 70 and older ... -
Sustaining an ageing population: the role of micronutrients in frailty and cognitive impairment
(2023)Age-related frailty and cognitive decline are complex multidimensional conditions that sign- ificantly impact the ability of older adults to sustain functional capacity and independence. While underlying causes remain ... -
Cognitive decline associated with anticholinergics,benzodiazepines and Z-drugs: Findings from The Irish Longitudinal Study on Ageing (TILDA)
(2020)Aims: To estimate the association between patterns of anticholinergic, benzodiazepine and Z-drug medication use and change in cognitive function in middle-aged and older adults. Methods: This prospective cohort study ... -
Aspirin prescribing for cardiovascular disease in middle-aged and older adults in Ireland: Findings from The Irish Longitudinal Study on Ageing
(2021)Aspirin use for cardiovascular indications is widespread despite evidence not supporting use in patients without cardiovascular disease (CVD). This study characterises aspirin prescribing among people aged ≥50 years in ... -
Investigating the effects of TLR2/MyD88 deficiency in mouse models of age-related macular degeneration
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2025)Age-related macular degeneration (AMD) is the leading cause of blindness among older populations. Despite its global prevalence, a definitive cure for AMD remains elusive. To tackle this, we are focused on modulating the ...
