School of Medicine: Recent submissions
Now showing items 161-180 of 3444
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Comparing Potentially Inappropriate Prescribing Tools and Their Association With Patient Outcomes
(2020)OBJECTIVE: To assess the agreement of several different measures of potentially inappropriate prescribing (PIP) in older people and compare their relationship with patient- reported outcomes. DESIGN: Prospective cohort ... -
Potentially inappropriate prescribing according to STOPP and START and adverse outcomes in community-dwelling older people: a prospective cohort study
(2016)AIMS: This study aims to determine if potentially inappropriate prescribing (PIP) is associated with increased healthcare utilization, functional decline and reduced quality of life (QoL) in a community-dwelling older ... -
Supine hypertension is associated with an impaired cerebral oxygenation response to orthostasis: Findings from the Irish Longitudinal Study on Ageing (TILDA)
(2021)The cerebrovascular effects of supine hypertension (SH) are still poorly understood. With aging and atherosclerosis of the vascular system, it is not uncommon for SH and non-neurogenic orthostatic hypotension to co-occur. ... -
Age and sex related differences in orthostatic cerebral oxygenation: Findings from 2764 older adults in the Irish Longitudinal Study on Ageing (TILDA).
(2022)Aims: Cerebral hypoperfusion is implicated in the pathogenesis of associations between orthostatic hypotension and adverse outcome such as falls, cognitive impairment, depression, and mortality. Although the blood pressure ... -
Age and sex differences in frontal lobe cerebral oxygenation in older adults - normative values using novel, scalable technology: Findings from the Irish Longitudinal Study on Ageing (TILDA)
(2019)Aims: Near-infrared spectroscopy (NIRS) is a non-invasive, easy to apply, optical technology for measuring cerebral blood oxygenation, but there is lack of comprehensive population data to aid interpretation and clinical ... -
Intergenerational Social Mobility and Allostatic Load in Midlife and Older Ages: A Diagonal Reference Modeling Approach
(2023)Objectives: This study aims to understand the association of life-course intergenerational social mobility with allostatic load (AL) burden in midlife and older ages in Ireland. Methods: The study involved biological ... -
An investigation of what protective individual- and community-level factors are associated with life satisfaction in middle-aged and older family carers in Ireland.
(2023)Background: Family care plays an essential role in providing care in society. However, caring can cause stress, and mental and physical responses to caring vary widely. Different outcomes for carers may reflect different ... -
Caring in the time of COVID-19, longitudinal trends in well-being and mental health in carers in Ireland: Evidence from the Irish Longitudinal Study on Ageing (TILDA).
(2022)Background: The COVID-19 pandemic in 2020 resulted in the older population being asked to remain at home and avoid other people outside their household. This could have implications for both receipt and provision of informal ... -
Stressful Life Events and Orthostatic Blood Pressure Recovery in Older Adults
(2015)Objective: The majority of the literature on stress and blood pressure (BP) concerns the increased risk of cardiovascular morbidity and mortality from high BP. Because the sympathetic nervous system is critical to the ... -
TILDA report to inform demographics for over 50s in Ireland for COVID-19 crisis
(The Irish Longitudinal Study on Ageing, Trinity College Dublin, 2020)To assist with planning for COVID-19, we have analysed the following to help identify numbers in at-risk cohorts based on extant national and international data for at-risk groups i.e. frailty, pre-frailty; cardiovascular ... -
Hair cortisol as a risk marker for increased depressive symptoms among older adults during the COVID-19 pandemic
(2022)Determining pre-existing biological risk markers of incident depression and other mental health sequelae after exposure to a new stressor would help identify vulnerable individuals and mechanistic pathways. This ... -
Hair glucocorticoids and resting-state frontal lobe oxygenation: Findings from The Irish Longitudinal Study on Ageing
(2021)Cerebral blood flow and oxygenation are crucial for maintaining healthy brain structure and function, with hypoperfusion and hypometabolism associated with neurodegenerative and neuropsychiatric conditions. Chronic stress ... -
The association between hair cortisol, hair cortisone, and cognitive function in a population-based cohort of older adults: Results from the Irish longitudinal study on ageing
(2020)Experimental evidence to date largely supports an association between the stress hormone cortisol and cognitive performance. Older adults, in particular, may be vulnerable to the neurotoxic effects of prolonged increases ... -
Plasma Lutein and Zeaxanthin Are Associated With Better Cognitive Function Across Multiple Domains in a Large Population-Based Sample of Older Adults: Findings from The Irish Longitudinal Study on Aging.
(2017)Background: Low blood serum or plasma concentrations of the xanthophyll carotenoids lutein and zeaxanthin have been implicated in poorer cognitive health in older adults. However, equivocal results from smaller studies ... -
Measurement Error, Reliability, and Minimum Detectable Change in the Mini-Mental State Examination, Montreal Cognitive Assessment, and Color Trails Test among Community Living Middle-Aged and Older Adults
(2016)Background: Knowing the reliability of cognitive tests, particularly those commonly used in clinical practice, is important in order to interpret the clinical significance of a change in performance or a low score on a ... -
Impaired orthostatic blood pressure recovery and cognitive performance at two-year follow up in older adults: The Irish Longitudinal Study on Ageing
(2016)Background: Prospective investigations of the association between impaired orthostatic blood pressure (BP) regulation and cognitive decline in older adults are limited, and findings to-date have been mixed. The aim of ... -
Obesity is associated with reduced cerebral blood flow - modified by physical activity
(2021)This study examined the associations of body mass index (BMI), waist-to-hip ratio (WHR), waist circum- ference (WC), and physical activity (PA) with gray matter cerebral blood flow (CBFGM ) in older adults. Cross-sectional ... -
Towards a consensus definition of allostatic load: a multi-cohort, multi-system, multi-biomarker individual participant data (IPD ) meta-analysis
(2023)Background: Allostatic load (AL) is a multi-system composite index for quantifying physiological dysregulation caused by life course stressors. For over 30 years, an extensive body of research has drawn on the AL framework ...
