School of Medicine: Recent submissions
Now showing items 21-40 of 3444
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Investigating the role of miRNAs in the resistance of oesophago-gastric cancer to cytotoxic therapy
(Trinity College Dublin. School of Medicine. Discipline of Surgery, 2025)Oesophago-gastric cancers are two of the most commonly diagnosed cancers and the majority of oesophageal adenocarcinoma (OAC) and gastric adenocarcinoma (GAC) patients are diagnosed at a late stage. The standard of care ... -
Molecular and clinical aspects of blood-brain barrier dysfunction in traumatic brain injury
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2025)Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. TBI ranges from mild to severe, with concussion being considered a form of mild TBI (mTBI). Long-term issues, such as cognitive impairment ... -
Novel Non-Invasive Investigation of Spinal Cord Electrical Activity in Health and Neurodegeneration
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2025)The spinal cord (SC) extends from the lower end of the medulla oblongata to the lumbar region and is divided into five segments: cervical, thoracic, lumbar, sacral, and coccygeal. The spinal cord, as part of the central ... -
A Comparative Evaluation of Two Delivery Methods for a Work Focused Fatigue Management Intervention for Individuals with Inflammatory Arthritis
(Trinity College Dublin. School of Medicine. Discipline of Occupational Therapy, 2025)ABSTRACT Background: Inflammatory Arthritis (IA) often leads to early work disability, impacting employment and causing socio-economic challenges. Fatigue is a major symptom that affects productivity and increases ... -
The Effects of Immunoregulatory Therapies on Human Macrophage Function and Metabolism: Implications for Mycobacterial Infections and Diseases
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2025)Tuberculosis (TB), an endemic infecƟous disease caused by Mycobacterium tuberculosis (Mtb) is a huge burden globally. Dexamethasone is a potent long-acƟng syntheƟc glucocorƟcoid (GC) and presently, the role of GC as an ... -
Optimising Electrode Montages in Conventional Transcranial Direct Current Stimulation and High-Definition Transcranial Direct Current Stimulation of the Cerebellum for Pain Modulation
(2025)The cerebellum is involved in pain processing and, therefore, an important target for non-invasive brain stimulation (NIBS) for analgesia. When targeting a brain region for NIBS, it can be difficult to ensure activation ... -
An Investigation of the Effect of Pulsed Radiofrequency Treatment of the Dorsal Root Ganglion on Cerebrospinal fluid, peripheral venous blood and DRG washings in patients with chronic lumbosacral radicular pain
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, Department of Surgery, Trinity College Dublin, the University of Dublin, 2025)The objective of this thesis is to investigate alterations in the cellular and peptide composition of cerebrospinal fluid, blood, DRG washings and saliva in patients with a diagnosis of chronic lumbar radicular pain scheduled ... -
An Exploration of the Neurological Manifestations of Non-Cirrhotic Chronic Hepatitis C Infection in Ireland in the Direct-Acting Antiviral Era
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2025)An Exploration of the Neurological Manifestations of Non-Cirrhotic Chronic Hepatitis C Infection in Ireland in the Direct-Acting Antiviral Era. Ferguson, Damien. University of Dublin, Trinity College, School of Medicine. ... -
Neurobiological and neuropsychological outcome of adults with a childhood diagnosis of Attention Deficit/Hyperactivity Disorder (ADHD)
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2015)There is a dearth of knowledge surrounding the neural mechanisms that determine the persistence or remission of ADHD into adulthood. Neuroimaging and neuropsychological studies have helped to better understand the biological ... -
Reduced intensity conditioning with fludarabine, busulfan and anti-T lymphocyte globulin (FluBu3ATLG) for older patients with myeloid disease: determinants of outcome and the role of cytokine-based predictive modelling
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, School of Medicine, Trinity College Dublin, 2025)Fludarabine, busulfan and anti-T lymphocyte globulin (FluBu3ATLG) for reduced intensity conditioned (RIC) haematopoietic stem cell transplantation is an established regimen for older patients with myeloid disease. We ... -
Differential Pathogenic Mechanisms Driving Stromal Cell Inflammatory Pathways in RA and PsA
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2025)Rheumatoid arthritis (RA) and Psoriatic arthritis (PsA) encompass two of the most prevalent forms of inflammatory arthritis (IA), an umbrella term for the vast range of autoimmune driven arthropathies characterised by ... -
Allogeneic haematopoietic stem cell transplantation using reduced-intensity fludarabine, busulfan and anti-T lymphocyte globulin with strategic donor lymphocyte infusion in older patients with myeloid malignancy
(2025)Fludarabine, busulfan and anti-T lymphocyte globulin (FLUBU3+ATLG) reduced-intensity conditioning is an established preparative regimen for allogeneic haematopoietic stem cell transplantation in older patients with myeloid ... -
Complex Trauma in Childhood: Informing Occupational Therapy Practice
(Trinity College Dublin. School of Medicine. Discipline of Occupational Therapy, 2025)Background: There is a dearth of evidence available to support occupational therapy practice with children experiencing complex trauma. No occupational therapy-specific guidelines exist. The occupational experiences of ... -
A Qualitative Exploration of Living with and Managing Post COVID-19 Condition
(Trinity College Dublin. School of Medicine. Discipline of Occupational Therapy, 2025)Background: Post COVID-19 condition, or long COVID, has been largely studied via quantitative assessments, focusing on symptom prevalence and severity. However, limited research has explored how individuals experience the ... -
Evaluating The Cost-Effectiveness of Repeated Serological Biomarker Screening Compared to the Khorana Risk Score for Guiding Thromboprophylaxis Prescription in Patients Receiving Chemotherapy
(2025)Background: The Khorana Risk Score (KRS), measured prior to treatment initiation, is the internationally recommended standard for guiding thromboprophylaxis prescriptions based on venous thromboembolism (VTE) risk in ... -
The Acceptability and Usability of Outcome Measures for Social Prescribing Services
(Trinity College Dublin. School of Medicine. Discipline of Paediatrics, 2025)Background: Social prescribing has gained momentum within healthcare systems globally, bridging the gap between medical and non-medical services. It offers significant benefits, particularly in improving mental health and ... -
The Introduction of Cost Sharing for Prescription Drugs: Evidence from The Irish Longitudinal Study of Ageing (TILDA)
(2021)Ageing populations and age-related morbidity present major challenges for advanced economies in managing rapidly increasing pharmaceutical expenditures. However, older people, particularly those with low incomes, may be ... -
The optimisation of a preselection methodology of heterotypic spheroids for the in vitro investigation of angiogenesis in lung cancer.
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2025)Lung cancer, particularly non-small cell lung cancer (NSCLC), is a leading cause of cancer-related deaths. Angiogenesis, the formation of new blood vessels, is essential for disease progression. The tumour microenvironment ... -
Creative activity in the ageing population: Key findings and conclusions
(2021)Creative activity participation was high among older adults with over half spending time on creative activities or hobbies at least weekly. Time spent listening to music or radio, and on hobbies or creative activities ... -
Cohort Profile Update: The Harmonised Cognitive Assessment Protocol Sub-study of The Irish Longitudinal Study on Ageing (TILDA-HCAP)
(2025)The Irish Longitudinal Study on Ageing—Harmonised Cognitive Assessment Protocol (TILDA-HCAP) is closely harmonized with the original Health and Retirement Study (HRS), The Northern Ireland Cohort longitudinal study of ...
