School of Medicine: Recent submissions
Now showing items 281-300 of 3444
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In vitro and in vivo characterization of [64Cu][Cu(elesclomol)] as a novel theranostic agent for hypoxic solid tumors
(2023)Hypoxic tumors are associated with therapy resistance and poor cancer prognosis, but methods to detect and counter tumor hypoxia remain insufficient. Our purpose was to investigate 64Cu(II)-elesclomol ([64Cu][Cu(ES)]) as ... -
Creating a 3D-printed pelvic phantom to explore the impact of Magnetic Resonance (MR) scanner noise in radiomics analysis, a technical note.
(2024)Reproducibility of radiomics features necessitates that scanner noise be considered prior to feature extraction. Phantom research provides the opportunity for such ‘ground truth’ measurements, without the additional ... -
Time, location and function of hypoxia-inducible factors are critical to therapeutic tumour response
(2024)Multiple lines of evidence confirm isoforms the strong association between the presence of hypoxia in solid tumours and poorer outcomes ihn patients with cancer resulting from both more aggressive tumour cell behaviour and ... -
Prehabilitation for Patients with Cancer Undergoing Radiation Therapy: a Scoping Review
(2024)Aims: Prehabilitation is a process of identifying and assessing factors that could compromise the physical and psychological health of patients undergoing cancer treatment and implementing an intervention to combat such ... -
A joint physics and radiobiology DREAM team vision – Towards better response prediction models to advance radiotherapy
(2024)Radiotherapy developed empirically through experience balancing tumour control and normal tissue toxicities. Early simple mathematical models formalized this practical knowledge and enabled effective cancer treatment to ... -
In silico analysis of overall survival with YBX1 in male and female solid tumours
(2024)The Y-box binding protein-1 (YBX1) gene codes for a multifunctional oncoprotein that is increasingly being linked to the regulations of many aspects of cancer cell biology. Disparities in treatment outcomes between male ... -
Clinicoradiological outcomes after radical radiotherapy for lung cancer in patients with interstitial lung disease.
(2023)Objective: Interstitial lung disease (ILD) is relatively common in patients with lung cancer with an incidence of 7.5%. Historically pre-existing ILD was a contraindication to radical radiotherapy owing to increased radiation ... -
Cardiovascular autonomic function and progression of age-related macular degeneration in The Irish Longitudinal Study of Ageing (TILDA)
(2024)Purpose: To examine if changes in hemodynamic measures during an orthostatic challenge were associated with progression of age-related macular degeneration (AMD) over a 4-year period in The Irish Longitudinal Study on ... -
Comparing Face-to-Face, Blended and Online Teaching Approaches for Practical Skill Acquisition: A Randomised Controlled Trial
(2024)Introduction: The efficacy of blended and online teaching methods for practical skill acquisition remains ambiguous, particularly for skills requiring haptic awareness and/or sensory training. This study aims to compare ... -
Diagnostic accuracy of 18F Prostate Specific Membrane Antigen (PSMA) PET-CT radiotracers in staging and restaging of high-risk prostate cancer patients and patients with biochemical recurrence: protocol for an overview of reviews
(2023)Background: Correct staging and risk stratification is essential in ensuring prostate cancer patients are offered the most appropriate treatment. Interest has been growing in the use of radiotracers targeting prostate ... -
Diagnostic accuracy of 18F Prostate Specific Membrane Antigen (PSMA) PET-CT radiotracers in staging and restaging of high-risk prostate cancer patients and patients with biochemical recurrence: an overview of reviews
(Seminars in Nuclear Medicine, 2024)The aim of this overview was to consolidate existing evidence syntheses and provide a comprehensive overview of the evidence for 18F-prostate specific membrane antigen (PSMA) PET/CT in the staging of high-risk prostate ... -
Investigating the Immune System in Parkinson's Disease
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2024)In 1817 James Parkinson first described the symptoms of the Parkinson's disease (PD). It is the second most common neurodegenerative disease worldwide, and cases are rising exponentially. Characteristic hallmarks of PD ... -
Outcomes of the LEAP feasibility trial - a low-threshold, exercise programme with protein supplementation to target frailty and poor physical functioning in people experiencing homelessness and addiction issues
(2024)Background: People experiencing homelessness are more likely to experience poor health with physical functioning deficits and frailty commonly reported. It is not well known how strategies to target physical functioning ... -
A qualitative study exploring policy-amenable factors influencing medical device-related patient safety from a lifecycle perspective
(Trinity College Dublin. School of Medicine. Discipline of Public Health & Primary Care, 2024)Thesis Title: A qualitative study exploring policy-amenable factors influencing medical device-related patient safety from a lifecycle perspective Author: Kathleen Rose Harkin Abstract Introduction: Medical devices ... -
Biomarker discovery in non-small cell lung cancer
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)In Ireland, lung cancer represents the third most common cancer, after breast and prostate cancer. Major improvements have been made in treating this disease with the advent of targeted therapies and immunotherapy. These ... -
The Role of Intermediaries in Connecting Community-Dwelling Adults to Local Physical Activity and Exercise: A Scoping Review
(2024)Introduction: Connecting inactive individuals to local physical activity (PA) and exercise, via intermediaries (professionals who can facilitate and support connections to non-medical services) may be an effective method ... -
The impact of Esophageal Oncological Surgery on perioperative immune function; implications for adjuvant immune checkpoint inhibition
(2022)Background: Immune checkpoint inhibitors (ICIs) are being investigated for their role as an adjunct in the multimodal treatment of esophageal adenocarcinoma (EAC). The most effective time to incorporate ICIs remains ... -
Investigating the susceptibility of treatment-resistant oesophageal tumours to natural killer cell-mediated responses
(2023)The majority of oesophageal adenocarcinoma (OAC) patients do not respond to multimodal treatment regimens and face dismal survival rates. Natural killer (NK) cells are crucial anti-tumour immune cells, and this study ... -
Acidosis significantly alters immune checkpoint expression profiles of T cells from oesophageal adenocarcinoma patients
(2023)Tumour acidosis contributes to cancer progression by inhibiting anti-tumour immunity. However, the effect of acidosis on anti-tumour T cell phenotypes in oesophageal adenocarcinoma (OAC) is unknown. Therefore, this study ...
