School of Medicine: Recent submissions
Now showing items 261-280 of 3444
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Examining short interval intracortical inhibition with different transcranial magnetic stimulation-induced current directions in ALS
(2024)Objective: To establish if induced current direction across the motor cortex alters the sensitivity of transcranial magnetic stimulation (TMS)-evoked short-interval intracortical inhibition (SICI) as an ALS biomarker. Methods: ... -
Investigation of oral problems using a novel oral symptom assessment tool in patients with advanced cancer and older patients with frailty.
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, School of Medicine, 2024)Oral symptoms are common in patients with advanced cancer. Certain oral symptoms like xerostomia are common in older patients. The prevalence of many oral symptoms is however unknown in older patients with frailty. Oral ... -
North Dublin Regional DATF Alcohol Research 2023 An exploration of the nature and extent of alcohol use within North County Dublin
(2024)The North Dublin Regional Drug & Alcohol Task Force was established in 2003 under the National Drug Strategy. It is one of 10 regional Task Forces in the country. It brings key stakeholders together to coordinate an evidence ... -
Low CD49d expression in newly diagnosed chronic lymphocytic leukaemia may be associated with high-risk features and reduced treatment-free-intervals
(2022)This study was carried out to assess the prognostic power of low CD49d expres- sion (≥10%) in newly diagnosed CLL patients using a previously described cohort. Eighty-five patients were included. Median age at diagnosis; ... -
Mutual Support Between Patients and Family Caregivers in Palliative Care
(Trinity College Dublin. School of Medicine. Discipline of Occupational Therapy, 2024)Background: Palliative care is an interdisciplinary care approach to improve quality of life and alleviate symptom distress for people living with life-limiting conditions and their families. A systematic review conducted ... -
Cell landscape of immunosuppressive reprogramming during fatal sepsis and severe-COVID-19 through scRNA-SEQ
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)It is evident that some patients with sepsis and septic shock are admitted to hospitals late in their illness, contributing to poor outcomes and high mortality rates across all age groups worldwide. Current diagnostic and ... -
An Evaluation of In-Hospital Stroke in Irish Acute Hospitals
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Introduction Between 1 and 17% of strokes occur in-hospital in patients hospitalised for another reason. In-hospital strokes are associated with worse outcomes and poor performance on quality-of-care measures of acute ... -
Biological Ageing: A study of telomere length and mitochondrial DNA copy number in anorexia nervosa
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)INTRODUCTION Patients with anorexia nervosa (AN) experience significant psychological and physical stress, which are risk factors for accelerated biological ageing. Telomeres are protective caps at the ends of chromosomes ... -
PO-1263: What every radiation oncologist should know about geriatric oncology: A global expert consensus
(2020)Purpose or Objective To establish a dedicated Radiation Oncology- Geriatric Oncology global curriculum for radiation and clinical oncology trainees worldwide Material and Methods An international Delphi Expert Consensus ... -
Metabolic Syndrome and Accelerated Biological Ageing
Introduction: Metabolic syndrome consists of the cluster of obesity, insulin resistance, hypertension, and atherogenic dyslipidaemia. This syndrome is a risk factor for all-cause mortality but has not been well characterised ... -
The Impact of Geriatric Assessment on Patient Outcomes in Radiation Oncology: A Pilot Study.
(2020)Introduction: The objective of this pilot study was to obtain preliminary data on the efficacy and feasibility of incorporating geriatric assessment (GA) into radiation oncology (RO) with regard to patient outcomes and ... -
Palliative care healthcare professionals' perspective on the Assisted Decision-Making (Capacity Act) 2015 in Ireland
(2024)Objectives: People receiving end-of-life care often require assistance with decision-making. We aimed to ascertain from the perspective of palliative care healthcare professionals in Ireland, the impact of the Assisted ... -
Creative activity in the ageing population
(2021)The following report presents findings on creative activity participation among older adults in Ireland using data from The Irish Longitudinal Study on Ageing (TILDA). TILDA is a nationally representative study of ... -
An Investigation into the Epidemiology and Genetic Relatedness of pig and human Clostridioides difficile isolates in Ireland
(Trinity College Dublin. School of Medicine. Discipline of Clinical Microbiology, 2024)Historically, Clostridioides difficile (C. difficile) has been associated with nosocomial diarrheal illness in older, immunocompromised patients, particularly in those on long-term antibiotics. However, cases of C. difficile ... -
Analysis of genotype and phenotype in Leber Hereditary Optic Neuropathy-affected patients and asymptomatic maternal relatives
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Analysis of genotype and phenotype in Leber Hereditary Optic Neuropathy-affected patients and asymptomatic maternal relatives MD in Clinical Medicine: Dr Clare Quigley Supervisor: Prof Lorraine Cassidy Introduction: Leber ... -
Exploring the Experience of Shame in Adult Survivors of Childhood Sexual Abuse Using a Mixed-Methods Approach
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2024)Childhood sexual abuse (CSA) is a worldwide problem that increases survivors' likelihood of experiencing a range of physical and mental health conditions. Survivors often feel, or are made to feel, shame surrounding their ... -
Investigating the Needs and Concerns of Lesbian, Gay, Bisexual, Transgender, Queer, or Questioning Cancer Patients
(2024)The needs and concerns of lesbian, gay, bisexual, transgender, queer, or questioning (LGBTQ+) patients with cancer remain poorly understood. This is important as LGBTQ+ patients have an elevated risk of developing certain ... -
Exploring Hypoxia in Prostate Cancer With T2-weighted Magnetic Resonance Imaging Radiomics and Pimonidazole Scoring
(2023)Background/Aim: Radiomics involves high throughput extraction of mineable precise quantitative imaging features that serve as non-invasive prognostic or predictive biomarkers. High levels of hypoxia are associated with a ...
