School of Medicine: Recent submissions
Now showing items 501-520 of 3444
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Characterising the Blood Pressure Response to Physical Counterpressure Manoeuvres Using Surface Electromyography in Adults with Long Covid
(2023)Objective: Orthostatic intolerance (OI) is common in Long Covid. Physical counterpressure manoeuvres (PCM) may improve OI in other disorders. We characterised the blood pressure-rising effect of PCM using surface ... -
A Cost-effectiveness Analysis of Human Immunodeficiency Virus, Hepatitis B Virus, and Hepatitis C Virus Screening in an Emergency Department in Ireland.
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)Background: The acceptability and utility of screening for HIV, HBV, and HCV in the ED has been demonstrated. Previous studies have reported cost-effectiveness of screening for either HIV mono-infection or HBV/HCV co-infection ... -
Incidence, prevalence and risk factors for low back pain in adolescent athletes: a systematic review and meta-analysis
(2022)Objective To investigate the incidence, prevalence, risk factors and morphological presentations of low back pain (LBP) in adolescent athletes. Design Systematic review with meta-analysis. Data sources Medline, Embase, ... -
Inflammatory markers of antipsychotic weight gain and cardiometabolic dysfunction in youth mental health disorders
Second generation antipsychotics (SGAs) are used in children and adolescents to treat psychotic symptoms in Early Onset Psychosis (EOP) and irritability and behaviours that challenge in autism spectrum disorder (ASD). ... -
Developing pedigree-based strategies to analyse whole genome sequencing data for complex disorders: learning from schizophrenia
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2023)Complex genetic disorders are impacted by a range of DNA variation. Next generation sequencing (NGS) allows for the direct examination of this variation, but large sample numbers are required to identify rare variants in ... -
The Effects of Glucose Deprivation and Ketone Supplementation on the Growth and Function of Neural Stem and Neuronal Precursor Cells
(Trinity College Dublin. School of Medicine. Discipline of Anatomy, 2023)The cellular and phenotypic effects that carbohydrate restriction have on brain development are unclear. Ketone bodies become a primary energy source in periods of prolonged glucose deprivation, due to dieting, strenuous ... -
Clinically-assisted hydration in patients in the last days of life (?CHELSEA II? trial): a cluster randomised trial
(2022)Introduction Provision of clinically assisted hydration (CAH) at the end of life is one of the most contentious issues in medicine. The aim of the ‘CHELsea II’ trial is to evaluate CAH in patients in the last days of life. ... -
Development of SIRT1 siRNA-carrying liposomes for treatment of prostate cancer
(2020)Sirtuin 1 (SIRT1) is a histone deacetylase (HDAC) from Sirtuin family and high expression of it induces activation of DNA repairing factors eventually leading either tumor suppression or tumor development in cellular ... -
Evaluation of the effect of solid and cationic lipids on siRNA delivery systems
(2020)This study aims to develop nanoparticles with different types of solid and cationic lipids and evaluate them as siRNA delivery systems. For this purpose, we prepared a series of lipid nanoparticles by combining cationic ... -
A promising approach to develop nanostructured lipid carriers from solid lipid nanoparticles: preparation, characterization, cytotoxicity and nucleic acid binding ability
(2020)We aimed to develop nanostructured lipid carriers (NLCs) displaying similar characteristics – particle size, polydispersity index, and zeta potential – with the model solid lipid nanoparticles (SLNs) for better comparability. ... -
Development of EphA2 siRNA-loaded lipid nanoparticles and combination with a small-molecule histone demethylase inhibitor in prostate cancer cells and tumor spheroids.
(2021)Background siRNAs hold a great potential for cancer therapy, however, poor stability in body fluids and low cellular uptake limit their use in the clinic. To enhance the bioavailability of siRNAs in tumors, novel, safe, ... -
Implementation of 26 Gy in five fractions over 1 week adjuvant radiotherapy for breast cancer: Prospective report of acute skin toxicity and consideration of resource implications
(2023)Purpose: In March 2020, a 1-week adjuvant breast radiotherapy schedule, 26 Gy in 5 fractions, was adopted to reduce the risk of COVID19 for staff and patients. This study quantifies acute toxicity rates and the effect ... -
Comparing Colon Capsule Endoscopy To Colonoscopy; A Symptomatic Patient?s Perspective
(2022)Background Colon Capsule Endoscopy (CCE) has proven efficacy in a variety of gastrointestinal diseases. Few studies have assessed patient-reported outcomes and preference between colonoscopy and CCE. Methods Patients ... -
Single or double headed capsules for the investigation of suspected small bowel bleeding: Are two heads better than one.
(2022)Background: Capsule endoscopy is now the accepted first line investigation for suspected small bowel (SB) bleeding. Recent evidence suggests the diagnostic yield for SB pathology may be higher for tailored double headed ... -
Clinical features and mortality predictors of older hospitalized patients with severe COVID-19 in Lima, Per?
(2022)Background and aims. The objective of our study was to describe the clinical features of severe COVID-19 in older (compared to younger) hospitalized patients in a tertiary care centre in Lima, Perú. Methods. A retrospective ... -
Blood Pressure Signal Entropy as a Novel Marker of Physical Frailty: Results from the FRAILMatics Clinical Cohort
(2022)In this study we investigated the association between information entropy in short length blood pressure signals and physical frailty status, in a group of patients aged 50+ recruited from the Falls and Syncope Unit at ... -
Low-volume HIIT and MICT speed VO2 kinetics during high-intensity "work-to-work" cycling with a similar time-course in type 2 diabetes
(2022)We assessed the rates of adjustment in oxygen uptake (V̇o2) and muscle deoxygenation [i.e., deoxygenated hemoglobin and myoglobin, (HHb + Mb)] during the on-transition to high-intensity cycling initiated from an elevated ... -
Priming exercise accelerates oxygen uptake kinetics during high-intensity cycle exercise in middle-aged individuals with type 2 diabetes
(2022)Background: The primary phase time constant of pulmonary oxygen uptake kinetics ( ⋅VO2 τ p) during submaximal efforts is longer in middle-aged people with type 2 diabetes (T2D), partly due to limitations in oxygen supply ...
