School of Medicine: Recent submissions
Now showing items 481-500 of 3444
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Mucosal Associated Invariant T Cells and Insulin Resistance in Hidradenitis Suppurativa
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)Hidradenitis suppurativa (HS) is a chronic, inflammatory skin disease characterised by recurrent painful nodules, abscesses and draining sinus tracts. There is a paucity of effective treatments and it severely impairs ... -
How and why do financial incentives contribute to helping people stop smoking? A realist review protocol
(2022)Introduction: Smoking is harmful to human health and programmes to help people stop smoking are key public health efforts that improve individual and population health outcomes. Research shows that financial incentives ... -
Public attitudes to implementing financial incentives in stopsmoking services in Ireland
(2023)Introduction: Financial incentives improve stop-smoking service outcomes. Views on acceptability can influence implementation success. To inform implementation planning in Ireland, public attitudes on financial incentives ... -
Relationship Between Sarcopenia and Orthostatic Blood Pressure Recovery in Older Falls Clinic Attendees
(2023)Purpose: Sarcopenia and delayed orthostatic blood pressure (BP) recovery are two disorders increasingly associated with adverse clinical outcomes in older adults. There may exist a pathophysiological link between the two ... -
Eight-year longitudinal falls trajectories and associations with modifiable risk factors: evidence from The Irish Longitudinal Study on Ageing (TILDA)
(2023)Background: The label 'faller' and the associated stigma may reduce healthcare-seeking behaviours. However, falls are not inevitably progressive and many drivers are modifiable. This observational study described the 8-year ... -
Exploring low back pain in adolescent athletes
(Trinity College Dublin. School of Medicine. Discipline of Physiotherapy, 2023)Low back pain (LBP) is a 'pain, ache or discomfort in the low back with or without referral to the buttocks or legs.' It is known that LBP affects people of all ages. Adolescents (aged 10 to 19 years old) experience LBP ... -
Use of a Living Lab approach to implement a smoke-free campus policy
(2023)While universities have increasingly become tobacco-/smoke-free, to our knowledge, no campus has reported 100% policy compliance. Innovative approaches to encourage compliance and ongoing data collection are needed. This ... -
The Pathological Associations of Hyperuricaemia in Sub-Clinical Gout, Cardiovascular and Cardiopulmonary Diseases
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)Abstract - Introduction Gout is a common and treatable disease caused by the deposition of MSU crystals in articular and non-articular structures. Hyperuricaemia is the most important risk factor for the development of ... -
Human Papilloma Virus Associated Oropharyngeal Squamous Cell Carcinoma: Genetic Aberrations Associated with Local and Distant Recurrence
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)Introduction HPV driven OPSCC proffers a more favourable prognosis in contrast to its HPV negative counterparts. Consequently, studies have analysed de-intensification measures of current treatment practices to minimise ... -
Corpus of Works submitted for Doctor of Science (Sc.D.)
(Trinity College Dublin. School of Medicine. Discipline of Histopathology, 2023) -
Exploring barriers and enablers to the delivery of Making Every Contact Count brief behavioural interventions in Ireland: a cross-sectional survey study
(2023)Objectives The public health impact of the Irish Making Every Contact Count (MECC) brief intervention programme is dependent on delivery by health care professionals. We aimed to identify enablers and modifiable barriers ... -
Understanding the Role of MicroRNA-31 in Regulating Cellular Sensitivity to Chemoradiotherapy in Pancreatic Ductal Adenocarcinoma
(Trinity College Dublin. School of Medicine. Discipline of Surgery, 2023)Pancreatic adenocarcinoma (PDAC) is a lethal malignancy with a poor survival rate. One main challenge regarding PDAC is resistance to chemotherapy and radiotherapy. Therefore, there is an urgent requirement to characterise ... -
A 5-Year Audit of Paediatric Patients Presenting to an Emergency Department with Status Epilepsy Requiring Second-Line Medication
(2023)Aim: Audit management of children presenting to Paediatric Emergency Department (PED) who require second-line medication for seizure control. Method: Retrospective electronic chart review over a 5-year period (March ... -
Prognostication in advanced cancer by combining actigraphy-derived rest-activity and sleep parameters with routine clinical data: an exploratory machine learning study
(2023)Survival prediction is integral to oncology and palliative care, yet robust prognostic models remain elusive. We assessed the feasibility of combining actigraphy, sleep diary data, and routine clinical parameters to ... -
Diagnostic test accuracy of dipstick urinalysis for diagnosing urinary tract infection in febrile infants attending the emergency department
(2022)Objective To report the diagnostic test accuracy of dipstick urinalysis for the detection of urinary tract infections (UTIs) in febrile infants aged 90 days or less attending the emergency department (ED). Design ... -
Building resilience and reversing frailty: a randomised controlled trial of a primary care intervention for older adults
(2023)Background: There is a need for effective primary care interventions that help older people combat frailty and build resilience. Objective: To study the effectiveness of an optimised exercise and dietary protein ... -
Predictive Microbiome Post-Bone Marrow Transplantation and Acute Graft versus Host Disease
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)Haemopoietic stem-cell transplantation serves as one of the life-saving options for the management of refractory haematological malignancies and rarely for non-malignant conditions. The era of transplantation has significantly ... -
Antipsychotics Prevent Psychosine Induced Toxicity in Glial Cells.
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2023)Glial cells are implicated in the neuropathophysiology of schizophrenia and other neuropsychiatric disorders. Also, the role of altered myelin in the onset and development of schizophrenia and changes in myelin due to ... -
Evaluating the role of angiogenesis in disease behaviour and therapy response in ulcerative colitis
Introduction Ulcerative colitis (UC) is a chronic inflammatory condition with a significant impact on quality of life. In this thesis two small molecule anti-angiogenic and anti-inflammatory agents were used to treat tissue ... -
Cerebral changes in Poliomyelitis survivors: A computational neuroimaging study
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)Post-polio syndrome (PPS) is a slowly progressive LMN condition that affects 20-85% of polio survivors many decades after their initial acute infection. While motor dysfunction is the hallmark of the disease, extra-motor ...
