School of Medicine: Recent submissions
Now showing items 641-660 of 3444
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Cytosolic dsRNA improves neonatal innate immune responses to adjuvants in use in paediatric vaccines.
(2022)Pattern recognition receptors (PRRs) of the innate immune system represent the critical front-line defense against pathogens, and new vaccine formulations target these PRR pathways to boost vaccine responses, through ... -
Minocycline suppresses disease-associated microglia (DAM) in a model of photoreceptor cell degeneration
(2022)As the resident immune cells in the retina, microglia play important homeostatic roles in retinal immune regulation and neuroprotection. However, chronic microglia activation is a common hallmark of many degenerative retinal ... -
SARM1 Promotes Photoreceptor Degeneration in an Oxidative Stress Model of Retinal Degeneration
(2022)SARM1 (sterile alpha and armadillo motif-containing protein) is a highly conserved Toll/IL-1 Receptor (TIR) adaptor with important roles in mediating immune responses. Studies in the brain have shown that SARM1 plays a ... -
Pain management in children and young adults with minor injury in emergency departments in the UK and Ireland: a PERUKI service evaluation
(2022)Background: Management of acute pain should commence at the earliest opportunity, as it has many short-term and long-term consequences. A research priority of Paediatric Emergency Research in the UK and Ireland (PERUKI) ... -
Network Analysis in Motor Neuron Diseases: A Cortico-Muscular Coherence Study
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2022)Neurodegenerative conditions are associated with widespread changes in the motor networks. There is preliminary evidence from (f)MRI studies that the structural changes extend beyond the primary motor areas in cortical ... -
Central and peripheral characterisation of TLR7/8 and endocannabinoid signalling in multiple sclerosis
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2022)Toll-like receptors (TLRs) are a class of pattern-recognition receptors (PRRs) involved in initiating an immune response to infection or endogenous damage. These receptors are expressed on cells of both the innate and ... -
Detection of Neurovascular Compression in Trigeminal Neuralgia by high-resolution Magnetic Resonance Angiography
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2022)Trigeminal neuralgia (TGN, tic douloureux) refers to sudden severe paroxysms of severe lancinating pain on one side of the face involving one or more branches of the trigeminal nerve (CN V) which usually lasts a few seconds ... -
Longitudinal study on Sustained Attention to Response Task (SART): clustering approach for mobility and cognitive decline
(2022)The Sustained Attention to Response Task (SART) is a computer-based go/no-go task to measure neurocognitive function in older adults. However, simplified average features of this complex dataset lead to loss of primary ... -
Predictors of submaximal exercise test attainment in adults reporting long COVID symptoms
(2022)Adults with long COVID often report intolerance to exercise. Cardiopulmonary exercise testing (CPET) has been used in many settings to measure exercise ability but has been conducted in a few long COVID cohorts. We conducted ... -
Post-operative management of flexor tendon injuries at zone II and flexor Pollicis Longus - a survey of Irish practice
(2021)Purpose The post-operative management of flexor tendon injuries has been the focus of considerable exploration and there continues to be variation in approaches and methods of mobilisation. The purpose of this paper is ... -
IL-36 cytokines imprint a colitogenic phenotype on CD4+ T helper cells.
(2022)IL-36 cytokines are emerging as potent orchestrators of intestinal inflammation and are being implicated in the pathogenesis of inflammatory bowel diseases (IBD). However, the mechanisms through which these cytokines mediate ... -
An Investigation into an Occupation-Focused Self-Management Programme for College Students experiencing Mental Health Difficulties.
(Trinity College Dublin. School of Medicine. Discipline of Occupational Therapy, 2022)Background: In response to ever increasing numbers of students in higher education experiencing mental health difficulties, an occupation-focused self-management programme, called the Unilink Self-Management Programme ... -
Review of the Implementation of the 2001 Report of the National Advisory Committee on Palliative Care as it relates to Adult Palliative Care
(Department of Health, Government of Ireland, 2022) -
Immunometabolic responses of adult and umbilical cord macrophages to stimulation with Mycobacterium tuberculosis or Lipopolysaccharide
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2022)Tuberculosis (TB) has been the biggest infectious killer in the world in the last decade and young children are among the most vulnerable groups. Mycobacterium tuberculosis (Mtb), the bacteria that causes TB, is phagocytosed ... -
Decision-making in palliative care - patient and family caregiver concordance and discordance: systematic review and narrative synthesis
(2023)Background: Decision-making in palliative care usually involves both patients and family caregivers. However, how concordance and discordance in decision-making manifest and function between patients and family caregivers ... -
Testing the feasibility of a primary-care exercise intervention to prevent and reverse early frailty and build resilience in community-dwelling older adults
(2022)Background: Resistance exercises have been shown to prevent and reverse frailty but their application in clinical practice is low. We wished to test the feasibility of an optimised exercise intervention for mild or pre-frailty ... -
Cerebral Blood Flow and Cerebrovascular Reactivity Measurement using Arterial Spin Labeling MRI: Data from The Irish Longitudinal Study on Ageing (TILDA)
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2022)Background: Cerebral blood flow (CBF) and cerebrovascular reactivity (CVR) are important measures of cerebrovascular integrity and may provide an imaging biomarker for the early detection of diseases such as dementia and ... -
The We Can Quit2 Smoking Cessation Trial: Knowledge Exchange and Dissemination Following a Community-Based Participatory Research Approach
(2022)Background: 'We Can Quit2' pilot randomised controlled trial determined the feasibility [of conducting a community-based trial of We Can Quit, a peer-delivered stop-smoking programme (group support, combination nicotine ... -
Does the future of epilepsy care lie in eHealth? An examination of attitudes and behaviours towards epilepsy self-management and eHealth from the perspectives of people with epilepsy, their carers and healthcare providers
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2022) -
Investigating the applicability of immune checkpoint blockade in upper gastrointestinal cancers
(Trinity College Dublin. School of Medicine. Discipline of Surgery, 2022)Oesophagogastric junctional adenocarcinoma (OGJ) is an aggressive malignancy with a high propensity to metastasise. Response rates to first-line chemo(radio)therapy regimens remain poor therefore, better treatment options ...
