School of Medicine: Recent submissions
Now showing items 741-760 of 3444
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The toll of unemployment in axial spondyloarthropathy: high prevalence and negative impact on outcomes captured in a national registry
(2021)Objective Axial spondyloarthropathy (axSpA) is an inflammatory arthritis of the axial skeleton. Persistent disease activity can result in significant disability and affect the ability to maintain employment. This study ... -
The Effect of Tuberculosis Antimicrobials on the Immunometabolic Profiles of Primary Human Macrophages Stimulated with Mycobacterium tuberculosis
(2021)Tuberculosis (TB) remains a global health challenge. Patients with drug-sensitive and drug-resistant TB undergo long, arduous, and complex treatment regimens, often involving multiple antimicrobials. While these drugs were ... -
Common patterns in the public reporting of waiting time and waiting list information: findings from a sample of OECD jurisdictions
(Trinity College Dublin/London School of Economics/Partnership for Health System Sustainability & re, 2021)We present findings from a review of published literature and administrative documentation on waiting time and waiting list reporting models for elective treatment in a sample of international jurisdictions (a subset of ... -
Cardiovascular Health in Professional Rugby Union Athletes
(Trinity College Dublin. School of Medicine. Discipline of Physiotherapy, 2021)Cardiovascular disease (CVD) defines a class of diseases relating to the heart and blood vessels, including coronary heart disease, coronary artery disease and hypertension. CVD risk and outcomes can be managed through ... -
The Generation and Characterisation of Novel Mouse Models of Haemophilia A
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)Haemophilia A (HA) is a hereditary, X-linked recessive disease caused by mutations in the F8 gene, with the absence or deficiency in the coagulation factor, Factor VIII (FVIII), resulting in a bleeding diathesis. The ... -
NEURODEVELOPMENTAL OUTCOME FOR TWINS OF THE ESPRiT STUDY: THE NOTES STUDY
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)THE NOTES STUDY: ABSTRACT Objective: The objective of the NOTES Study was to study the effect of birthweight growth discordance (≥ 20%) on neurodevelopmental outcome and physical growth of monochorionic and dichorionic ... -
Comparison of gait speed reserve, usual gait speed, and maximum gait speed of adults aged 50+ in Ireland using explainable machine learning
(2021)Gait speed is a measure of general fitness. Changing from usual (UGS) to maximum (MGS) gait speed requires coordinated action of many body systems. Gait speed reserve (GSR) is defined as MGS–UGS. From a shortlist of 88 ... -
Gone in 60 days: our first experience with a bioconvertible IVC filter
(Springer Science and Business Media LLC, 2021)The Sentry bioconvertible IVC filter (Boston Scientific, MA, USA) contains a bioabsorbable filament which hydrolyses after 60 days, allowing the arms of the filter to spring open, retract into the vessel wall and endothelialise, ... -
The clinical and neuroimaging profiles of primary lateral sclerosis: a longitudinal research study
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)Primary Lateral Sclerosis (PLS) is a progressive, idiopathic upper motor neuron (UMN) disease. Clinically, PLS is defined by the presence of spasticity and associated UMN signs without concurrent evidence of lower motor ... -
Longitudinal trajectories of pulse wave velocity and cognition in the Irish longitudinal study of ageing (TILDA)
(2021)Introduction: Arterial stiffness is a marker of vascular ageing and carotid–femoral pulse wave velocity (cf-PWV) is a standard measurement method. A raised cf-PWV in individuals has been associated cross-sectionally with ... -
Frail by Different Measures: A Comparison of 8-year Mortality in The Irish Longitudinal Study on Ageing (TILDA)
(2021)Purpose: We compared the ability of four frailty identification tools (frailty phenotype: FP; FRAIL scale; 32-item Frailty Index: FI; and Clinical Frailty Scale: CFS) to predict 8-year mortality in TILDA. Methods: We ... -
The Relationship between Radiological Paraspinal Lumbar Measures and Clinical Measures of Sarcopenia in Older Patients with Chronic Lower Back Pain
(2021)Objectives: Sarcopenia is postulated to be an influential factor in chronic low back pain. The aim of this study is to evaluate the relationship between traditional clinical measures of sarcopenia and novel radiographic ... -
Associations between Cardiovascular Signal Entropy and Cognitive Performance over Eight Years
(2021)In this study, the relationship between non-invasively measured cardiovascular signal entropy and global cognitive performance was explored in a sample of community-dwelling older adults from The Irish Longitudinal Study ... -
Prehabilitation during a pandemic: preoperative exercise to improve fitness in patients undergoing complex surgery for cancer of the lung or oesophagus, the PRE-HIIT trial: an updated study protocol
(2021)Background: Pre-operative fitness is an established predictor of postoperative outcome; accordingly, targeting pre-operative fitness through exercise prehabilitation has logical appeal. Exercise prehabilitation for patients ... -
In vitro assessment of primary human chondrocyte viability following treatment with intra-articular contrast agents and local anaesthetic
(Trinity College Dublin. School of Medicine. Discipline of Surgery, 2021)Title In vitro assessment of primary human chondrocyte viability following treatment with intra-articular contrast agents and local anaesthetic. Introduction Magnetic resonance (MR) and computed tomography (CT) direct ... -
In-depth profiling of drug resistance to PI3K-mTOR inhibition and intra-tumour heterogeneity in NSCLC
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)Lung cancer has an overall 5-year survival rate of less than 15% and is the leading cause of cancer-related death worldwide. As such, it is crucial we develop new treatment strategies to overcome this formidable disease. ... -
Investigating the role of IL-36 cytokines in mediating angiogenesis and vascular permeability
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)Neovascular blinding conditions including age related macular degeneration and diabetic retinopathy are the most common causes of blindness in the elderly and working age populations respectively. Currently the best-in-class ...
