School of Medicine: Recent submissions
Now showing items 761-780 of 3444
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Proportion of deaths in hospital in European countries: trends and associations from panel data (2005–2017)
(2021)Background: End-of-life care attracts major policy interest. Place of death is an important metric of individual experience and health system performance. Most people prefer to die at home, but hospital is the most common ... -
Defining the role of RORα in the functionality of distinct immune cell populations
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)The transcription factor Retinoic acid-related Orphan Receptor (ROR)-a has roles in metabolism, circadian rhythm and cellular development, such as Th17 cells and group 2 innate lymphoid cells (ILC2). The identification ... -
Ketamine for depression: Clinical use and media accounts
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)This thesis comprises two research studies, one of which is a clinical trial. Study 1: Pilot randomised controlled trial: Ketamine as an adjunctive therapy for major depression, the Karma-Dep Trial (NCT03256162). The ... -
Study of Macular Pigments in Glaucoma
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)The macula can be involved in the early stage of glaucoma, as evidenced by the presence of paracentral scotoma on visual field tests (Drance 1969) or thinning of the ganglion cell complex (GCC) layer on optical coherence ... -
The Clinical Applications of Serum and Urinary Biomarkers in Prostate Cancer
(2020)At every stage of the prostate cancer journey from screening and diagnosis to management of advanced disease, patients and clinicians face dilemmas and decisions that can impact long-term outcomes. Although traditional ... -
The Clinical Applications of Tissue Biomarkers in Prostate Cancer
(2020)The clinical course of localized prostate cancer varies widely, from indolent disease unlikely to need treatment to aggressive disease requiring intensive, multimodal therapy. Traditionally, treatment decisions have been ... -
The Iron Chelator Desferrioxamine Increases the Efficacy of Bedaquiline in Primary Human Macrophages Infected with BCG
(2021)For over 50 years, patients with drug-sensitive and drug-resistant tuberculosis have undergone long, arduous, and complex treatment processes with several antimicrobials. With the prevalence of drug-resistant strains on ... -
In their own words: The voices of Older Irish people in the COVID-19 pandemic
(The Irish Longitudinal Study on Ageing, Trinity College Dublin, 2021)Since COVID-19 was declared an international pandemic by the World Health Organisation (WHO) in March 2020 (HSE, 2021), older people have carried the greatest burden of serious infection and death from the virus. ... -
SART and individual trial mistake thresholds: predictive model for mobility decline
(2021)The Sustained Attention to Response Task (SART) has been used to measure neurocognitive functions in older adults. However, simplified average features of this complex dataset may result in loss of primary information and ... -
The Importance of Age in the Prediction of Mortality by a Frailty Index: A Machine Learning Approach in the Irish Longitudinal Study on Ageing
(2021)The quantification of biological age in humans is an important scientific endeavor in the face of ageing populations. The frailty index (FI) methodology is based on the accumulation of health deficits and captures variations ... -
A study of the repeatability of the Bruce Treadmill Protocol in measuring V̇O2max and in estimating V̇O2max through prediction equations
(Trinity College Dublin. School of Medicine. Discipline of Physiotherapy, 2021)Introduction: Maximal oxygen consumption (V̇O2max) is a measure of cardiopulmonary fitness, and a strong indicator of risk of cardiovascular disease (CVD); with a lower V̇O2max increasing a person's risk of CVD. The most ... -
ACE gene I/D polymorphism and severity of SARS-CoV-2 infection in hospitalized patients: a metanalysis
(2021)Background Hypertension and type 2 diabetes increase the risk of severe SARS-CoV-2 infection. On the other hand, homozygous ACE deletion polymorphism (DD) has been associated with these two diseases and risk of acute ... -
Relationship between serum 25-hydroxyvitamin D concentration and acute inflammatory markers in hospitalized patients with SARS-CoV-2 infection: a systematic review
(2021)INTRODUCTION: There is experimental and clinical evidence that the serum concentration of 25-hydroxyvitamin D [25(OH)D)] may decrease in acute systemic inflammatory responses; in this context, low values may not necessarily ... -
Assessing the Efficacy and Safety of Bimodal Neuromodulation for the Management of Symptomatic Tinnitus
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)Tinnitus is defined as the perception of sound in the absence of an external auditory stimulus. It is a common symptom, affecting 5 30% of the general population, however only 1 3% of patients report the symptom to be ... -
Endovascular management of delayed upper gastrointestinal bleeding after open esophagectomy for a benign oesophageal stricture
(2021)Introduction: Delayed upper gastrointestinal (GI) bleeding is a rare complication of esophagectomy and can be difficult to manage. Presentation: A 76-year-old female represented 17 days post open esophagectomy ... -
Time and belief in exercise importance predict increased activity during initial COVID-19 restrictions in Ireland
(2021)The aim of this work was to investigate physical activity levels and the associated barriers and facilitators to physical activity in Irish adults during initial COVID-19 restrictions. Members of the general population ... -
Reducing Sedentary Behaviour in the Workplace: A Theory-led Multicomponent Intervention
(Trinity College Dublin. School of Medicine. Discipline of Public Health & Primary Care, 2021)There is strong evidence demonstrating that there is a relationship between greater time spent in sedentary behaviour (SB) and greater all-cause mortality, cardiovascular disease mortality and incidence, type 2 diabetes ... -
Colon capsule endoscopy is a viable alternative to colonoscopy for the investigation of intermediate- and low-risk patients with gastrointestinal symptoms: results of a pilot study
(2021)Background and study aims: Colon capsule endoscopy (CCE) is a recommended viable alternative to colonoscopy for colonic visualisation in a variety of clinical settings with proven efficacy in polyp detection, surveillance, ... -
Involving older people in co-designing a primary-care intervention to reverse frailty and build resilience
(2021)Background: An essential consideration in health research is to conduct research with members of the public rather than for them. Public and patient involvement (PPI) of older people in research can improve enrolment, ... -
A Profile of Physical Fitness Variables in an Out-Patient Adult Population with Narcolepsy
(Trinity College Dublin. School of Medicine. Discipline of Physiotherapy, 2021)Background: Narcolepsy is a disabling lifelong condition that impacts an individuals ability to regulate sleep-wake patterns. Narcolepsy can significantly impact the physical and mental wellbeing of people with narcolepsy, ...
