School of Medicine: Recent submissions
Now showing items 861-880 of 3444
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Approximate entropies of resting state continuous neurocardiovascular physiological signals are associated with physical frailty in older adults
(2021)Frailty in older adults is characterised by dysregulation in multiple physiological systems. The frailty phenotype is defined on the basis of exhaustion, unexplained weight loss, weakness, slowness and low physical activity ... -
Methyl-CpG2-binding protein 2 mediates overlapping mechanisms across brain disorders
(2020)MECP2 and its product, Methyl-CpG binding protein 2 (MeCP2), are mostly known for their association to Rett Syndrome (RTT), a rare neurodevelopmental disorder. Additional evidence suggests that MECP2 may underlie other ... -
Functional network mapping reveals state-dependent response to IGF-1 treatment in Rett Syndrome
(2020)Rett Syndrome (RTT) is a neurodevelopmental disorder associated with mutations in thegeneMeCP2, which is involved in the development and function of cortical networks. The clinical presentation of RTT is generally severe ... -
The role of angiopoietins and their mediators in symptomatic small bowel angiodysplasia; identifying novel diagnostic and therapeutic targets in chronic anaemia and obscure gastrointestinal bleeding
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)Title : The role of angiopoietins and their mediators in symptomatic small bowel angiodysplasia; identifying novel diagnostic and therapeutic targets in chronic anaemia and obscure gastrointestinal bleeding. Author: Dr ... -
Gender and Neonatal Inflammation in Preterm Outcome
(Trinity College Dublin. School of Medicine. Discipline of Paediatrics, 2021)Introduction: Preterm neonates are at high risk of sepsis and sepsis-related complications. Despite the prominence of sepsis in neonatal practice, there is no consensus definition and the role of organ dysfunction in ... -
Severity and Mortality of SARS-COV-2 infection and 25-hydroxyvitamin D concentration: a metanalysis
(2021)Introduction: There is increasing scientific interest in the possible association between hypovitaminosis D and the risk of SARS-CoV-2 infection severity and/or mortality. Objective: To conduct a metanalysis of the ... -
A Survey to Establish Current Practice in Addressing Work Participation with Inflammatory Arthritis in the Irish Clinical Setting.
(2018)Background: Inflammatory arthritis (IA) is a complex progressive disease, with 2,250cases diagnosed in Ireland annually (Kane & Kavanagh, 2011) and an average age at onset of 35–45 years (Health Service Executive,2015). ... -
Hemodynamic and structural brain measures in high and low sedentary older adults
(2021)Due to its cardiovascular effects sedentary behaviour might impact cerebrovascular function in the long term, affecting cerebrovascular regulatory mechanisms and perfusion levels. Consequently this could underly potential ... -
Development of an Objective Assessment of the Cognitive, Posturographic, and Electrophysiological Phenotype of the Fragile X Premutation, and analysis of their contribution to Postural Instability.
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)The Fragile X Premutation is a complex genetic anomaly which affects one in 260 females and 400 males and results in a broad range of symptoms and distinct conditions. The premutation phenotype involves cognitive and motor ... -
Duplication of the pituitary gland
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The implementation of a collaborative peer learning 2:1 model of practice placement education within dietetics pre-registration training in Ireland
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)The educational approach towards practice education in health-related disciplines has changed in recent years. The use of collaborative peer learning models of practice education has increased, associated with positive ... -
CO-MORBIDITIES OF HIDRADENITIS SUPPURATIVA
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)Hidradenitis suppurativa (HS), is a chronic inflammatory skin disorder which can have debilitating consequences if not managed appropriately from early on of its course of disease. Patients with this condition, also ... -
Advice for physiotherapists, (massage therapists, and other clinicians in very close contact) treating rowing athletes during and post Covid-19 pandemic
(World Rowing, 2021)Purpose: physiotherapists (and other clinicians working in very close contact with rowers) may be operating in multiple settings (small clinics, acute hospital settings, sports institutes). The aim of this document is to ... -
Addressing Participation with Early Inflammatory Arthritis: Insights into the Lived Experience and Exploring a Clinical Model to Address Participation Restrictions
(Trinity College Dublin. School of Medicine. Discipline of Occupational Therapy, 2021)The focus of this multiphase study is exploring the impacts of inflammatory arthritis on participation and engagement in life roles, and how clinical services address client-identified participation restrictions associated ... -
A rare case of acute necrotising pancreatitis in a paediatric patient
(2020)The diagnosis of acute necrotising pancreatitis is a rare event in the Paediatric Emergency Department (ED). We report a case of acute pancreatitis in a paediatric patient, diagnosed in our ED, a tertiary level paediatric ... -
Characterisation of the role of IL-18 in neovascular AMD
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)Age-related macular degeneration is the leading cause of vision loss in the over 50’s in developed countries, accounting for 8.7% of all blindness worldwide. AMD is a progressive disease affecting the macula region of the ... -
2021 consensus statement for preventing and managing low back pain in elite and subelite adult rowers
(2021)Purpose: To synthesise evidence on low back pain (LBP) in adult rowers and to create a consensus statement to inform clinical practice. Methods: There were four synthesis steps that informed the consensus statement. In ... -
Transitions in frailty phenotype states and components over 8 years: evidence from The Irish Longitudinal Study on Ageing
(2021)Aim: Fried's frailty phenotype (FP) is defined by exhaustion (EX), unexplained weight loss (WL), weakness (WK), slowness (SL) and low physical activity (LA). Three or more components define the frail state, and one or two ... -
Role of Protein Phosphatase 2A inhibition in modulation of VE-cadherin and Claudin-5 in human brain microvascular endothelial cells and the potential reversal by small molecule activators of PP2A (SMAPs)
(Trinity College Dublin. School of Medicine. Discipline of Pharmacology & Therapeutics, 2021)Protein phosphatase 2A (PP2A) is a serine/threonine phosphatase which plays a key role in modulating signalling, metabolism and cell growth, and is implicated in various pathologies. There is conflicting evidence regarding ...
