School of Medicine: Recent submissions
Now showing items 841-860 of 3444
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Cross phenotype association mapping of the MHC identifies genetic variants that differentiate psoriatic arthritis from psoriasis
(2017)Objectives: Psoriatic arthritis (PsA) is a chronic inflammatory arthritis, with a strong heritable component, affecting patients with psoriasis. Here we attempt to identify genetic variants within the major histocompatibility ... -
Alkylating histone deacetylase inhibitors may have therapeutic value in experimental myeloperoxidase-ANCA vasculitis
(2018)Current therapies for treating antineutrophil cytoplasm autoantibody (ANCA)–associated vasculitis include cyclophosphamide and corticosteroids. Unfortunately, these agents are associated with severe adverse effects, despite ... -
Low Density Granulocytes in ANCA Vasculitis Are Heterogenous and Hypo-Responsive to Anti-Myeloperoxidase Antibodies.
(2019)Low Density Granulocytes (LDGs), which appear in the peripheral blood mononuclear cell layer of density-separated blood, are seen in cancer, sepsis, autoimmunity, and pregnancy. Their significance in ANCA vasculitis (AAV) ... -
Study Protocol for DeCOmPRESS: Defining the Disease Course and Immune Profile of COVID-19 in the Immunosuppressed Patient
(2021)The ongoing coronavirus disease 2019 (COVID-19) pandemic is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Current advisory guidelines for high-risk groups—including people with autoimmune disease ... -
Human Poxvirus protein MC132 from Molluscum Contagiosum Virus inhibits NF-κB activation by targeting p65 for degradation.
(2015)Molluscum contagiosum virus (MCV) is unique in being the only known extant, human-adapted poxvirus, yet to date, it is very poorly characterized in terms of host-pathogen interactions. MCV causes persistent skin lesions ... -
Poxviral Targeting of Interferon Regulatory Factor Activation.
(2020)As viruses have a capacity to rapidly evolve and continually alter the coding of their protein repertoires, host cells have evolved pathways to sense viruses through the one invariable feature common to all these pathogens—their ... -
Editorial: low population mortality from COVID-19 in countries south of latitude 35 degrees North supports vitamin D as a factor determining severity
(2020)The excellent review by Al-Ani et al reflects a consensus approach to management of inflammatory bowel disease during the SARS-CoV-2 pandemic that has been established remarkably rapidly by very effective international ... -
Preventing vitamin D deficiency during the COVID-19 pandemic: UK definitions of vitamin D sufficiency and recommended supplement dose are set too low
(2021)There is growing evidence linking vitamin D deficiency with risk of COVID-19. It is therefore distressing that there is major disagreement about the optimal serum level for 25-hydroxyvitamin D (25(OH)D) and appropriate ... -
Orthostatic hypotension and novel blood pressure associated gene variants in older adults: data from the TILDA Study
(2020)Orthostatic hypotension (OH) is associated with increased risk of trauma and cardiovascular events. Recent studies have identified new genetic variants that influence orthostatic blood pressure (BP). The aim of this study ... -
Perspective: Vitamin D supplementation prevents rickets and acute respiratory infections when given as daily maintenance but not as intermittent bolus: Implications for COVID-19
(2021)The value of vitamin D supplementation in the treatment or prevention of various conditions is often viewed with scepticism as a result of contradictory results of randomised trials. It is now becoming apparent that there ... -
New Insights and Knowledge on Cognition and Dementia from Population-Based Cohort of Older Adults in India.
(2020)The Longitudinal Aging Study in India (LASI) is the world's largest aging survey, a groundbreaking nationally representative longitudinal survey to examine aging and retirement among India's aged 45 and older population. ... -
Potentially inappropriate medication use in older adults with mild-moderate Alzheimer's disease: prevalence and associations with adverse events.
(2020)Aim: Potentially inappropriate medication (PIM) use is prevalent in older adults and is associated with adverse events, hospitalisation and mortality. We assessed the patterns and associations of PIM use in older adults ... -
Physical activity partially mediates associations between ¿Big¿ personality traits and incident generalized anxiety disorder: Findings from the irish longitudinal study on ageing
(Elsevier BV, 2020)Background: This study aimed to examine associations of personality with generalized anxiety disorder (GAD) and physical activity (PA), PA with GAD, and PA mediates associations between personality and incident GAD. Methods: ... -
Does the choice of Allostatic Load scoring algorithm matter for predicting age-related health outcomes?
(2020)Allostatic Load (AL) is posited to provide a measure of cumulative physiological dysregulation across multiple biological systems and demonstrates promise as a sub-clinical marker of overall health. Despite the large ... -
Risk Factors for Incident Dementia Among Older Cubans.
(2020)Introduction: Little is known about risk factors of dementia in Latin American countries. We aimed to identify socio–demographic, health and lifestyle risk factors of incident dementia in Cuban older adults. Methods: Data ... -
Increased Salt Intake for Orthostatic Intolerance Syndromes: A Systematic Review and Meta-Analysis.
(2020)Guidelines recommend increased salt intake as a first-line recommendation in the management of symptomatic orthostatic hypotension and recurrent syncope. There have been no systematic reviews of this intervention. We sought ... -
Perspective: Vitamin D deficiency and COVID-19 severity - plausibly linked by latitude, ethnicity, impacts on cytokines, ACE2 and thrombosis.
(2020)SARS‐CoV‐2 coronavirus infection ranges from asymptomatic through to fatal COVID‐19 characterized by a ‘cytokine storm’ and lung failure. Vitamin D deficiency has been postulated as a determinant of severity. -
A High Prevalence of Vitamin D Deficiency Observed in an Irish South East Asian Population: A Cross-sectional Observation Study
(2020)At northern latitudes, non-ethnic population groups can be at an increased risk of vitamin D deficiency (defined as a 25-hydroxyvitamin D [25(OH)D] status ≤30 nmol/L). The vitamin D status of ethnic minority groups has ... -
Clinical and Cost-effectiveness of a Pre-exposure Prophylaxis (PrEP) Programme to prevent HIV
(Trinity College Dublin. School of Medicine. Discipline of Public Health & Primary Care, 2021)Introduction There has been an increase in HIV notifications in recent years in Ireland. PrEP is a form of HIV prevention whereby oral antiretrovirals are taken by HIV-negative individuals to prevent infection. The aim ... -
Human Neurodegeneration: A Spectral EEG and TMS based Approach in Amyotrophic Lateral Sclerosis
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)Amyotrophic lateral sclerosis (ALS) is defined by the neurodegeneration of upper and lower motor neurons of the corticospinal tract, resulting in progressive, terminal and incurable decline in movement, speech and swallowing ...
