School of Medicine: Recent submissions
Now showing items 961-980 of 3444
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From Mechanisms to Analgesia: Towards the Use of Non-Invasive Neuromodulation for Pain Relief in the Clinic
(Intech Open, 2020)The use of electricity for analgesic effects has a long history and yet currently neuromodulation devices based on electrical stimulation are typically restricted to being a last resort intervention for pain patients after ... -
Feasibility of a Broad Test Battery to Assess Physical Functioning Limitations of People Experiencing Homelessness
(2021)Background: People who are homeless experience poor health. Reflective of overall health and factors such as acquired injuries, physical ability or functioning is often low among people who are homeless, but there is a ... -
Personalised Medicine in ANCA-Associated Vasculitis: The Role of Urine Soluble CD163
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)In this thesis I have identified a highly sensitive and specific association between urinary sCD163 and active renal vasculitis in the clinical setting of renal vasculitis flare in both retrospective and prospective studies. ... -
Physical and Mental Health of Older People while Cocooning during the COVID-19 Pandemic
(2021)Background: Cocooning or shielding, i.e. staying at home and reducing face-to-face interaction with other people, was an important part of the response to the COVID-19 pandemic for older people. However, concerns exist ... -
Video-based online interviews for palliative care research: a new normal in COVID-19?
(2021)There is no doubt thatCOVID-19 has significantly disrupted the course of health and clinical research. In some cases, researchers may have had to arrest data collection or re-design studies to accommodate to COVID-19.However, ... -
A Real-world Prospective Cohort Study to Examine the Relationship Between Simple Physical Functioning Tests and Complications Following Abdominal Surgery
(2020)BACKGROUND:The relationship between physical function and the development of complications in people after abdominal surgery is not well known. The objective of this study was to prospectively examine the relationship ... -
Clinical and Demographic Features of Voluntary and Involuntary Admissions under Ireland's Mental Health Act, 2001: The Dublin Involuntary Admission Study (DIAS), 2008-2018
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)Involuntary admission and treatment are common, long-standing features of psychiatry but the relationships between diagnosis, demographic factors and other elements of involuntary treatment are not clear. Involuntary ... -
Brain Health in Retired Professional Rugby Union Players with a History of Concussion/Head Impact Exposure
(Trinity College Dublin. School of Medicine. Discipline of Physiotherapy, 2021)Rugby has one of the highest incidences of concussion among all full-contact sports. There has been a global increase in rugby participation, now estimated at over eight million people worldwide. With the introduction of ... -
Age-related normative changes in cerebral perfusion: data from The Irish Longitudinal Study on Ageing (TILDA)
(2021)Objective: To establish normative reference values for total grey matter cerebral blood flow (CBFGM) measured using pseudo-continuous arterial spin labelling (pCASL) MRI in a large cohort of community-dwelling adults aged ... -
Functional Analysis of Continuous, High-Resolution Measures in Ageing Research: A Demonstration using Cerebral Oxygenation Data from The Irish Longitudinal Study on Ageing
(2020)Background: A shift towards the dynamic measurement of physiologic resilience and improved technology incorporated into experimental paradigms in aging research is producing high-resolution data. Identifying ... -
Impaired orthostatic heart rate recovery is associated with smaller thalamic volume: Results from The Irish Longitudinal Study on Aging (TILDA)
(Wiley, 2020)The thalamus is a central hub of the autonomic network and thalamic volume has been associated with high‐risk phenotypes for sudden cardiac death. Heart rate response to physiological stressors (e.g., standing) and the ... -
Grey matter volume in the right Angular Gyrus is associated with differential patterns of multisensory integration with ageing
(Elsevier BV, 2020)Multisensory perception might provide an important marker of brain function in ageing. However, the cortical structures supporting multisensory perception in ageing are poorly understood. In this study, we compared regional ... -
Characterisation of the efficacy of two novel host-directed therapies, SCD-19 and 4-octyl itaconate, for the treatment of Pseudomonas aeruginosa infection in cystic fibrosis.
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)Cystic Fibrosis (CF) is a life limiting genetic disease, which is caused by genetic mutations which result in defective function of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR). In CF, patients experience ... -
One-dimensional statistical parametric mapping identifies impaired orthostatic cerebrovascular and cardiovascular response in frailty index
(2020)Background: Orthostasis is a potent physiological stressor which adapts with age. The age-related accumulation of health deficits in multiple physiological systems may impair the physiological response to orthostasis ... -
The interactions of apolipoprotein E and inflammation in human iPSC-derived astrocytes
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2020)Alzheimer’s disease (AD) is a devastating neurodegenerative disease characterised histologically by the presence of extracellular plaques and intracellular neurofibrillary tangles, and clinically by memory ... -
A Precision Medicine Approach to Dosing and Management of Continuous Renal Replacement Therapy for Acute Kidney Injury
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2020)Background: Despite decades of research, the mainstay of treatment for severe acute kidney injury (AKI) in the critical care setting remains renal replacement therapy in the form of dialysis. Continuous renal replacement ... -
Associations between neurocardiovascular signal entropy and physical frailty
(2021)In this cross-sectional study, the relationship between noninvasively measured neurocardiovascular signal entropy and physical frailty was explored in a sample of community-dwelling older adults from The Irish Longitudinal ... -
Protocol for a randomised controlled trial of a primary care intervention to Reverse Frailty and Enhance Resilience through Exercise and dietary protein Education (REFEREE) in community-dwelling adults aged 65 and over
(2020)Introduction: Resistance exercises and dietary protein have been shown to reverse frailty, yet they are not commonly offered in clinical practice. We aim to measure changes in health outcomes, including physical frailty ... -
The role of eHealth to promote physical activity in people with cancer.
(Trinity College Dublin. School of Medicine. Discipline of Physiotherapy, 2020)The role of eHealth to promote physical activity in people with cancer. Ciar?n Haberlin BSc (Physiotherapy), P.Grad. Cert (Clinical Exercise) Background Exercise and physical activity (PA) are established and effective ... -
Investigating the Role of Extracellular Polysaccharides in Biofilm Formation of Klebsiella pneumoniae
(Trinity College Dublin. School of Medicine. Discipline of Clinical Microbiology, 2020)Klebsiella pneumoniae (K. pneumoniae) is the most significant and clinically relevant species in the Klebsiella genus of Enterobacteriaceae and is the causative agent of a variety of infections, including pneumonia, urinary ...
