Medical Gerontology: Recent submissions
Now showing items 121-140 of 529
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TILDA report to inform demographics for over 50s in Ireland for COVID-19 crisis
(The Irish Longitudinal Study on Ageing, Trinity College Dublin, 2020)To assist with planning for COVID-19, we have analysed the following to help identify numbers in at-risk cohorts based on extant national and international data for at-risk groups i.e. frailty, pre-frailty; cardiovascular ... -
Hair cortisol as a risk marker for increased depressive symptoms among older adults during the COVID-19 pandemic
(2022)Determining pre-existing biological risk markers of incident depression and other mental health sequelae after exposure to a new stressor would help identify vulnerable individuals and mechanistic pathways. This ... -
Hair glucocorticoids and resting-state frontal lobe oxygenation: Findings from The Irish Longitudinal Study on Ageing
(2021)Cerebral blood flow and oxygenation are crucial for maintaining healthy brain structure and function, with hypoperfusion and hypometabolism associated with neurodegenerative and neuropsychiatric conditions. Chronic stress ... -
The association between hair cortisol, hair cortisone, and cognitive function in a population-based cohort of older adults: Results from the Irish longitudinal study on ageing
(2020)Experimental evidence to date largely supports an association between the stress hormone cortisol and cognitive performance. Older adults, in particular, may be vulnerable to the neurotoxic effects of prolonged increases ... -
Plasma Lutein and Zeaxanthin Are Associated With Better Cognitive Function Across Multiple Domains in a Large Population-Based Sample of Older Adults: Findings from The Irish Longitudinal Study on Aging.
(2017)Background: Low blood serum or plasma concentrations of the xanthophyll carotenoids lutein and zeaxanthin have been implicated in poorer cognitive health in older adults. However, equivocal results from smaller studies ... -
Measurement Error, Reliability, and Minimum Detectable Change in the Mini-Mental State Examination, Montreal Cognitive Assessment, and Color Trails Test among Community Living Middle-Aged and Older Adults
(2016)Background: Knowing the reliability of cognitive tests, particularly those commonly used in clinical practice, is important in order to interpret the clinical significance of a change in performance or a low score on a ... -
Impaired orthostatic blood pressure recovery and cognitive performance at two-year follow up in older adults: The Irish Longitudinal Study on Ageing
(2016)Background: Prospective investigations of the association between impaired orthostatic blood pressure (BP) regulation and cognitive decline in older adults are limited, and findings to-date have been mixed. The aim of ... -
Obesity is associated with reduced cerebral blood flow - modified by physical activity
(2021)This study examined the associations of body mass index (BMI), waist-to-hip ratio (WHR), waist circum- ference (WC), and physical activity (PA) with gray matter cerebral blood flow (CBFGM ) in older adults. Cross-sectional ... -
Towards a consensus definition of allostatic load: a multi-cohort, multi-system, multi-biomarker individual participant data (IPD ) meta-analysis
(2023)Background: Allostatic load (AL) is a multi-system composite index for quantifying physiological dysregulation caused by life course stressors. For over 30 years, an extensive body of research has drawn on the AL framework ... -
Early life adversity and age acceleration at mid-life and older ages indexed using the next-generation GrimAge and Pace of Aging epigenetic clocks.
(2021)Objective: This retrospective cross-sectional study was designed to explore whether the experience of childhood adversity was associated with epigenetic age acceleration in mid-life and older ages using the next ... -
GrimAge outperforms other epigenetic clocks in the prediction of age-related clinical phenotypes and all-cause mortality.
(2021)The aging process is characterized by the presence of high interindividual variation between individuals of the same chronical age prompting a search for biomarkers that capture this heterogeneity. Epigenetic clocks measure ... -
Epigenetic clocks and allostatic load reveal potential sex-specific drivers of biological ageing
(2019)Allostatic load (AL) and epigenetic clocks both attempt to characterize the accelerated aging of biological systems, but at present it is unclear whether these measures are complementary or distinct. This study examines ... -
Speed of Heart Rate Recovery in Response to Orthostatic Challenge: A Strong Risk Marker of Mortality.
(2016)Rationale: Speed of heart rate recovery (HRR) may serve as an important biomarker of aging and mortality. Objective: To examine whether the speed of HRR after an orthostatic maneuver (ie, active stand from supine position) ... -
Cerebral haemodynamics in older adults: Multi-modal studies utilizing near infrared spectroscopy and non-invasive continuous blood pressure monitoring in a large longitudinal cohort
(Trinity College Dublin. School of Medicine. Discipline of Medical Gerontology, School of Medicine, Trinity College Dublin, 2025)Sufficient cerebral blood flow (CBF) is critical for brain health and normal cognitive function, and cerebral hypoperfusion is implicated as a pathway to cognitive decline, as well as other adverse outcomes such as falls, ... -
Validation of the 8-item Centre for Epidemiological Studies Depression Scale in a cohort of community-dwelling older people: data from The Irish Longitudinal Study on Ageing (TILDA)
(2018)Background The aim of this study was to validate the 8-item Centre for Epidemiological Studies Depression Scale (CES- D-8) against the 20-item version (CES-D-20) in a large sample of community-dwelling older people. Methods ... -
Depressive symptoms among older adults pre- and post- COVID-19 pandemic
(2021)Objectives: It is a concern that public health measures to prevent older people contracting COVID-19 could lead to a rise in mental health problems such as depression. The aim of this study therefore is to examine trends ... -
Vitamin D Deficiency Is Associated With an Increased Likelihood of Incident Depression in Community-Dwelling Older Adults.
(2019)Objective: To examine the prospective relationship between vitamin D status and incident depression in a large cohort of nondepressed community-dwelling older people. Design: Longitudinal study examining the relationship ... -
The `Wish to Die' in later life: prevalence, longitudinal course and mortality. Data from TILDA
(2021)Background: ‘Wish to Die’ (WTD) involves thoughts of or wishes for one’s own death or that one would be better off dead. Objective: To examine the prevalence, longitudinal course and mortality-risk of WTD in community-dwelling ... -
What Is the Relationship Between Orthostatic Blood Pressure and Spatiotemporal Gait in Later Life?
(Wiley, 2020)BACKGROUND/OBJECTIVES: Little work to date has examined the relationship between gait performance and blood pressure (BP) recovery after standing in later life. The aim of this study is to clarify the association of ...
