Medical Gerontology: Recent submissions
Now showing items 301-320 of 529
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Choice reaction time and subsequent mobility decline: Prospective observational findings from The Irish Longitudinal Study on Ageing (TILDA)
(2020)Background: Cognitive and motor function in ageing are intertwined, but whether slower motor response time (MRT) to a cognitive stimulus could herald accelerated mobility decline is unknown. Using data from The Irish ... -
Home FIRsT: interdisciplinary geriatric assessment and disposition outcomes in the Emergency Department
(2020)Background: Older people in the Emergency Department (ED) are clinically heterogenous and some presentations may be better suited to alternative out-of-hospital pathways. A new interdisciplinary comprehensive geriatric ... -
Severity of SARS-Cov-2 infection and angiotensin‐converting enzyme inhibitors and angiotensin receptor blockers: a meta-analysis
(2020)Background: The mechanism of entry of SARS-CoV-2 into the human host cell is through the ACE2 receptor. During the pandemic, a hypothesis has been proposed that angiotensin-converting enzyme inhibitors (ACEIs) and ... -
Lack Of Association Between Angiotensin-converting Enzyme (Ace) Genotype And Essential Hypertension In Peruvian Older People
(2020)Background: Epidemiological studies have shown an association between the ACE gene I / D polymorphism with arterial hypertension, specifically the DD genotype in different populations. The objective of this study is to ... -
Lack of association between angiotensin-converting enzyme genotype and muscle strength in Peruvian older people
(2020)Aging can be associated with decreasing muscle strength, and related factors are comorbidities, sex, physical activity, and possibly genetic factors. Among genetic factors the renin-angiotensin system is of interest, but ... -
Exploring Novel Biomarkers of Brain Health in Midlife Type 2 Diabetes Mellitus (ENBIND)
(Trinity College Dublin. School of Medicine. CentreFor Medical Gerontology, 2020)Type 2 Diabetes Mellitus (T2DM) in midlife (between the ages of 35-65) is associated with a two-fold increased risk of dementia in later life. Despite this, knowledge around the pathophysiological mechanisms linking T2DM ... -
Ageing outcomes in women and men in Ireland: the role of the religious social context
(Trinity College Dublin. School of Medicine. CentreFor Medical Gerontology, 2020)Aim & background: The aim of this thesis is to explore how the religious social context in Ireland has helped shape the health and ageing outcomes of older women and men. Understanding the factors behind the ability to ... -
Loneliness and social isolation in the COVID-19 pandemic among the over 70s. Data from The Irish Longitudinal Study on Ageing
(TILDA, 2020)This joint report from TILDA and ALONE examines the issues of loneliness and social isolation with specific reference to the COVID-19 pandemic in Ireland. Measures introduced to curtail the spread of COVID-19, including ... -
Functional Analysis of Continuous, High-Resolution Measures in Ageing Research: A Demonstration using Cerebral Oxygenation Data from The Irish Longitudinal Study on Ageing
(2020)Background: A shift towards the dynamic measurement of physiologic resilience and improved technology incorporated into experimental paradigms in aging research is producing high-resolution data. Identifying the most ... -
Clinical clustering of eight orthostatic haemodynamic patterns in The Irish Longitudinal Study on Ageing (TILDA)
(2020)Background: Orthostatic hypotension (OH) can be assessed with non-invasive continuous beat-to-beat haemodynamic monitoring during active stand (AS) testing; this yields large volumes of data outside the scope ... -
A pharmacological perspective of Chloroquine in SARS-CoV-2 infection
(2020)The pandemic caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is having serious consequences on health and the economy worldwide. All evidence-based treatment strategies need to be ... -
Clustering of behavioural symptoms and their associations with cognitive decline in older adults
(2020)Objectives: To examine (i) the clustering of reduced falls-efficacy, social withdrawal and physical activity withdrawal in Irish adults aged 50 years and older, and (ii) the concurrent and prospective associations of these ... -
Predictors of physical activity in older adults early in an emergency hospital admission: a prospective cohort study
(2020)Background: Reduced mobility may be responsible for functional decline and acute sarcopenia in older hospitalised patients. The drivers of reduced in-hospital mobility are poorly understood, especially during the early ... -
Angiotensin-Converting Enzyme (ACE) genetic variation and longevity in Peruvian older people: a cross-sectional study
(2020)Background: Some studies have suggested that the insertion(I)/deletion(D) polymorphism of the Angiotensin-Converting Enzyme (ACE) gene may be associated with human longevity, especially in centenarians. However, this ... -
Changes in Muscle Strength and Physical Function in Older Patients During and After Hospitalisation: a Prospective Repeated-Measures Cohort Study
(2020)Aim: To investigate changes in knee-extension strength and physical function in older adults during and after acute hospital admission, and the contributions of illness severity, frailty and sedentary activity to changes ... -
Syncope, fear of falling and quality of life among older adults: findings from The Irish Longitudinal Study on Ageing (TILDA)
(2020)Objective: Syncope is a prevalent condition that has a marked impact on quality of life. We examined the association between syncope and quality of life (QoL) and whether this association was explained by fear of falling ... -
Primary care interventions to address physical frailty among community-dwelling adults aged 60 years or older: A meta-analysis
(2020)Introduction: The best interventions to address frailty among older adults have not yet been fully defined, and the diversity of interventions and outcome measures makes this process challenging. Consequently, there is ... -
COVID-19 deaths in Irish Nursing Homes: exploring variation and association with the adherence to national regulatory quality standards
(CPEC-LSE, 2020)The COVID-19 pandemic has disproportionately affected nursing home residents worldwide, with Ireland having one of the highest reported proportions of COVID-19 deaths in this setting. In Ireland, the publication of a ... -
Admissions for Orthostatic Hypotension: an Analysis of NHS England Hospital Episode Statistics Data
(2019)Objectives To determine whether admissions for orthostatic hypotension (OH) and its consequences, such as falls, have changed over the past 10 years in the National Health Service (NHS) England. Setting Data from NHS ...
