Biochemistry: Recent submissions
Now showing items 201-220 of 1067
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A population of proinflammatory T cells coexpresses αβ and γο T cell receptors in mice and humans
(2020)T cells are classically recognized as distinct subsets that express αβ or γδ TCRs. We identify a novel population of T cells that coexpress αβ and γδ TCRs in mice and humans. These hybrid αβ-γδ T cells arose in the murine ... -
UCP3 reciprocally controls CD4+ Th17 and Treg cell differentiation
(2020)Uncoupling proteins (UCPs) are members of the mitochondrial anion carrier superfamily that can mediate the transfer of protons into the mitochondrial matrix from the intermembrane space. We have previously reported UCP3 ... -
A Pertussis Outer Membrane Vesicle-Based Vaccine Induces Lung-Resident Memory CD4 T Cells and Protection against Bordetella pertussis, including Pertactin Deficient Strains
(2019)Pertussis is a respiratory infectious disease that has been resurged during the last decades. The change from the traditional multi-antigen whole-cell pertussis (wP) vaccines to acellular pertussis (aP) vaccines that consist ... -
Next-generation pertussis vaccines based on the induction of protective t cells in the respiratory tract
(2020)Immunization with current acellular pertussis (aP) vaccines protects against severe pertussis, but immunity wanes rapidly after vaccination and these vaccines do not prevent nasal colonization with Bordetella pertussis. ... -
Identification of novel innate immune mechanisms regulating oesophageal adenocarcinoma (OAC) progression and bacterial infection
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2020)Inflammation is an essential immune system response to pathogens, damaged cells and stress stimuli and has an essential role in tissue repair and regeneration. The inflammatory response is the coordinated activation of ... -
Evidence of a role for Interleukin-6 in anoikis resistance and bioenergetic programming in oral squamous cell carcinoma
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2021)Oral squamous cell carcinoma (OSCC) is the sixth most common type of cancer in the world and accounts for more than 90% of oral malignancies. Oral squamous cell carcinomas are usually preceded by oral premalignant ... -
Immune dysfunction in the skin disease hidradenitis suppurativa
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2020)Hidradenitis suppurativa (HS) is a chronic, relapsing, inflammatory skin disease. Painful lesions and boils present at hair follicles of the inframammary fold, genitals, groin, buttocks and perianal areas. Severe cases ... -
Characterisation of Membrane Glycoproteins that are Essential for Flagellar Attachment in the Bloodstream Form of Trypanosoma brucei
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2020)The African trypanosome, Trypanosoma brucei, is a unicellular parasitic protist that causes a severe disease, trypanosomiasis, in humans and livestock in sub-Saharan Africa. The trypanosome has a single flagellum that ... -
Diverse Immunoregulatory Roles of Oxysterols - The Oxidized Cholesterol Metabolites
(2020)Intermediates of both cholesterol synthesis and cholesterol metabolism can have diverse roles in the control of cellular processes that go beyond the control of cholesterol homeostasis. For example, oxidized forms of ... -
Metabolic but not transcriptional regulation by PKM2 is important for Natural Killer cell responses
(2020)Natural Killer (NK) cells have an important role in immune responses to viruses and tumours. Integrating changes in signal transduction pathways and cellular metabolism is essential for effective NK cells responses. The ... -
Characterizing caspase-1 involvement during esophageal disease progression.
(2020)Barrett’s esophagus (BE) is an inflammatory condition and a neoplastic precursor to esophageal adenocarcinoma (EAC). Inflammasome signaling, which contributes to acute and chronic inflammation, results in caspase-1 activation ... -
Spiroindoline-Capped Selective HDAC6 Inhibitors: Design, 2 Synthesis, Structural Analysis, and Biological Evaluation
(2020)Histone deacetylase inhibitors (HDACi) have emerged as promising therapeutics for the treatment of neurodegeneration, cancer, and rare disorders. Herein, we report the development of a series of spiroindoline-based HDAC6 ... -
Evaluation of the anti-cancer effects of a novel guanidinium-based compound, VP79s, in multiple myeloma
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2020)Multiple myeloma (MM) is an incurable haematological malignancy accounting for 300-350 cancer diagnoses in Ireland each year. Mainly a disease of the elderly, MM is most prevalent in Western societies where aging populations ... -
Pharmacological Activation of Pyruvate Kinase M2 Inhibits CD4+ T Cell Pathogenicity and Suppresses Autoimmunity
(2020)A multitude of diverse microorganisms, termed the microbiota, reside in the gut, respi-ratory tract, skin, and genital tract of humans and other animals. Recent advances inmetagenomic sequencing and bioinformatics have ... -
Caspase-11 promotes allergic airway inflammation
(2020)Activated caspase-1 and caspase-11 induce inflammatory cell death in a process termed pyroptosis. Here we show that Prostaglandin E2 (PGE2) inhibits caspase-11-dependent pyroptosis in murine and human macrophages. PGE2 ... -
Nano-particle mediated M2 macrophage polarization enhances bone formation and MSC osteogenesis in an IL-10 dependent manner
(2020)Engineering a pro-regenerative immune response following scaffold implantation is integral to functional tissue regeneration. The immune response to implanted biomaterials is determined by multiple factors, including ... -
Osteoarthritis-associated basic calcium phosphate crystals alter immune cell metabolism
(2020)A number of studies have demonstrated that molecules called ‘alarmins’ or danger-associated molecular patterns (DAMPs), contribute to inflammatory processes in the OA joint. Metabolic reprogramming of immune cells, including ... -
Citrate, oxaloacetate and 2-hydroxyglutarate in the control of inflammatory macrophage activation
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2020)Immunometabolism is the study of changes that occur in the metabolic pathways of an immune cell during its activation. For macrophages, the remodelling of their metabolism following activation supports the adoption of ... -
HAMLET and synthetic derivatives as pre-operative agents in the treatment of oral and oesophageal cancer
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2020)Oral and oesophageal cancers are aggressive tumours that are frequently diagnosed late, with high morbidity, mortality, and difficulties in surgical and therapeutic intervention. Novel imaging probes could assist in early ... -
The immunomodulatory properties of L-rhamnose
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2020)L-Rhamnose is a non-mammalian monosaccharide ubiquitously found on the surface of both commensal and pathogenic bacteria. Previous publications had identified that L-rhamnose-rich Mycobacterium tuberculosis glycolipids, ...
