Biochemistry: Recent submissions
Now showing items 61-80 of 1067
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Investigating sex differences in the mitochondria of CD4+ and CD8+ T lymphocytes
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2024)Sex differences in immunity have been observed in many contexts including infectious diseases, cancer, and autoimmunity. Females generally mount stronger innate and adaptive responses, and as a result tend to have lower ... -
Unravelling the inflammatory landscape of hidradenitis suppurativa
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2024)Hidradenitis suppurativa (HS) is a chronic, relapsing, inflammatory skin disease characterised by painful lesions at hair follicles of the inframammary fold, genitals, groin, buttocks and perianal areas. Follicular ... -
Studying the inhibitory effect of oxysterols on NK-92 metabolism and cytotoxicity
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)NK cell-based immunotherapy has become a promising cancer treatment for cancer. One approach is the use of NK cell lines such as NK-92 as this overcomes many of the technical challenges associated with the use of human NK ... -
Delineating the mechanisms utilised by Staphylococcus aureus to survive intracellularly within phagocytes
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)Staphylococcus aureus (S. aureus) is a major human pathogen in addition to being an important part of the human microbiome. The bacterium has evolved a large array of immune evasion mechanisms to facilitate its persistence ... -
Antiviral activity of human hepatocytes and its regulation by cellular antioxidant systems
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)Although several antiviral strategies have been developed in the last decade, hepatotropic viruses are still a significant public health burden, with more than 300 million people being affected worldwide. Hepatocytes, the ... -
Publisher Correction: Dimethyl fumarate and 4-octyl itaconate are anticoagulants that suppress Tissue Factor in macrophages via inhibition of Type I Interferon (Nature Communications, (2023), 14, 1, (3513), 10.1038/s41467-023-39174-1)
(2023)The original version of this Article contained an error in the spelling of the surname for the author Luke A J O’Neill, which was incorrectly given as ‘O’ Neill’ with an additional space. This has now been corrected in ... -
Dimethyl fumarate and 4-octyl itaconate are anticoagulants that suppress Tissue Factor in macrophages via inhibition of Type I Interferon
(2023)Excessive inflammation-associated coagulation is a feature of infectious diseases, occurring in such conditions as bacterial sepsis and COVID-19. It can lead to disseminated intravascular coagulation, one of the leading ... -
Intranasal COVID-19 vaccine induces respiratory memory T cells and protects K18-hACE mice against SARS-CoV-2 infection
(2023)Current COVID-19 vaccines prevent severe disease, but do not induce mucosal immunity or prevent infection with SARS-CoV-2, especially with recent variants. Furthermore, serum antibody responses wane soon after immunization. ... -
Nasal vaccines for pertussis
(2023)Whooping cough, caused by Bordetella pertussis, is still a major cause of morbidity and mortality worldwide. Current acellular pertussis (aP) vaccines induce potent circulating IgG and prevent severe disease in children/adults ... -
Immunopathological features of early age cancer: microsatellite instability in colorectal cancer
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)Title: Immunopathological features of early age cancer: microsatellite instability in colorectal cancer Background and hypothesis Deciphering the interplay between tumour biology and the immune system may aid the design ... -
Investigation of Staphylococcus aureus-induced immunosuppression during nasal colonisation and the implications for vaccine function
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)Staphylococcus aureus (S. aureus) is a major part of the natural human microbiome, primarily colonising the anterior nares. The overall aim of this project was to determine the impacts nasal colonisation has on local and ... -
Oxysterols - new players in regulation of Natural Killer cells
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)Natural Killer (NK) cells are cytotoxic, innate lymphocytes that play a crucial role in mediating viral and tumour responses as well as supporting tissue homeostasis. Due to their fast acting immune response independent ... -
Innate immune phenotype variation in bovine health and disease
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)Infectious diseases are estimated to cost the global agriculture industry $300 billion annually and present significant challenges to animal welfare. Disease burden in cattle and other livestock species also threaten ... -
Investigation of the PTP4A3 oncogene and how it mechanistically regulates autophagy in ovarian cancer
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)Ovarian cancer has the highest mortality rates of all gynaecologic malignancies. High mortality rates are associated with poor levels of early detection due to asymptomatic tumour growth and limited screening programmes. ... -
Investigation into the Molecular Mechanisms Underlying Chemoresistance in Malignant Rhabdoid Tumours
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)Malignant rhabdoid tumour (MRT) is a rare and aggressive paediatric malignancy associated with poor prognosis and is, unfortunately, highly refractive to treatment. One of the major issues when treating MRT patients is the ... -
Adaptive Expression of Forgotten Engrams
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)Long-term memories are stored as stable configurations of neuronal ensembles, termed engrams. While investigation of engram cell properties and functionality in memory recall has been extensive, less is known about how ... -
Role of the Elongator complex in innate immune responses of macrophages
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)The innate immune system functions as the first line of defence against pathogen infection. Innate immune systems are functionally present across the animal kingdom and mediate host defence against infection via a myriad ... -
Identification of Anticoagulant Properties of Dimethyl Fumarate and 4-Octyl Itaconate via Suppression of the Macrophage Type I Interferon-Tissue Factor Axis
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)The host response to infection is characterized by activation of the innate immune and blood coagulation systems, which collectively detect, neutralize, and prevent dissemination of the invading pathogen, maintaining ... -
Modulation of haematopoiesis by protozoal and helminth parasites
(2023)During inflammation, haematopoietic stem cells (HSCs) in the bone marrow (BM) and periphery rapidly expand and preferentially differentiate into myeloid cells that mediate innate immune responses. HSCs can be directed into ... -
Bystander activation of Bordetella pertussis-induced nasal tissue-resident memory CD4 T cells confers heterologous immunity to Klebsiella pneumoniae
(2023)Tissue-resident memory CD4 T (TRM) cells induced by infection with Bordetella pertussis persist in respiratory tissues and confer long-term protective immunity against reinfection. However, it is not clear how they are ...
