| dc.contributor.author | MC LOUGHLIN, DECLAN | en |
| dc.date.accessioned | 2012-01-24T16:08:57Z | |
| dc.date.available | 2012-01-24T16:08:57Z | |
| dc.date.issued | 2010 | en |
| dc.date.submitted | 2010 | en |
| dc.identifier.citation | Lau KF, Perkinton MS, Rodriguez L, McLoughlin DM, Miller CC, An X11[alpha]/FSBP complex represses transcription of the GSK3[beta] gene promoter., NeuroReport, 21, 11, 2010, 1-6 | en |
| dc.identifier.other | Y | en |
| dc.description | PUBLISHED | en |
| dc.description.abstract | X11? is a neuronal adaptor protein that interacts with the amyloid precursor protein (APP) via a centrally located phosphotyrosine binding (PTB) domain to inhibit production of A? peptide that is deposited in Alzheimer's disease brains. X11? also contains two C-terminal postsynaptic density-95, discs large, zona occludens 1 (PDZ) domains and we show here that via its PDZ domains, X11? interacts with a novel transcription factor, fibrinogen silencer binding protein (FSBP). Moreover, we demonstrate that an X11?/FSBP complex signals to the nucleus to repress glycogen synthase kinase-3? (GSK3?) promoter activity. GSK3? is a favoured candidate kinase for phosphorylating tau in Alzheimer's disease. Our findings reveal a new function for X11? that may impact on Alzheimer's disease pathogenesis. | en |
| dc.description.sponsorship | This work was supported by grants from the Wellcome Trust, Alzheimer's Research Trust, MRC, Alzheimer's Association, the Research Grant Council Hong Kong and the Chinese University of Hong Kong direct grant scheme and an award from the C.Y. Kwan/Lee Hysan Foundation Endowment Funds/Sino-British Fellowship Trust Fund for staff development.
Supported by Wellcome Trust, Alzheimer's Research Trust, MRC, Alzheimer's Association, Research Grant Council Hong Kong, CUHK grant scheme, C.Y. Kwan/Lee Hysan Foundation. | en |
| dc.format.extent | 1-6 | en |
| dc.language.iso | en | en |
| dc.relation.ispartofseries | NeuroReport | en |
| dc.relation.ispartofseries | 21 | en |
| dc.relation.ispartofseries | 11 | en |
| dc.rights | Y | en |
| dc.subject | Neuroscience | en |
| dc.subject | Alzheimer's disease | en |
| dc.title | An X11[alpha]/FSBP complex represses transcription of the GSK3[beta] gene promoter. | en |
| dc.type | Journal Article | en |
| dc.type.supercollection | scholarly_publications | en |
| dc.type.supercollection | refereed_publications | en |
| dc.identifier.peoplefinderurl | http://people.tcd.ie/mclougde | en |
| dc.identifier.rssinternalid | 67372 | en |
| dc.identifier.rssuri | http://dx.doi.org/10.1097/WNR.0b013e32833bfca0 | en |
| dc.contributor.sponsor | Wellcome Trust | en |
| dc.identifier.uri | http://hdl.handle.net/2262/61828 | |
