Histopathology & Morbid Anatomy: Recent submissions
Now showing items 21-40 of 106
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Molecular Mechanisms of Advanced Prostate Cancer
(Trinity College Dublin. School of Medicine. Discipline of Histopathology, 2018)Globally, prostate cancer is the fourth most common cancer type. Five year survival rates for primary localised disease are high, however these figures decrease significantly with the onset of metastasis. Obesity and ... -
The silencing of HPV16 Oncogenes using E6siRNAs
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2014)Cervical cancer is the fourth most common cancer worldwide and remains a rising cause of cancer deaths amongst women worldwide, particularly in low to mid-income countries. High risk HPV is the main etiological factor in ... -
Diagnostic and prognostic biomarkers in ovarian cancer
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2013)Ovarian cancer is the fifth most common cancer in women and the most frequent cause of gynaecological malignancy-related mortality in women. The vast majority present in advanced stages and this is due to lack of a reliable ... -
Molecular features of aggressive prostate carcinoma
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2015)Prostate cancer is the most common form of malignancy in the male urinary tract and accounts for more than 20% of all newly diagnosed male cancer cases. The vast majority of prostate tumours are clinically insignificant, ... -
Platinum and taxane chemoresistance mechanisms in ovarian cancer cells
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2015)Ovarian cancer is the leading cause of death from a gynaecological malignancy, typically presenting at late stage due to difficult diagnosis and lack of suitable screening tools. The standard treatment of combination ... -
HPV mRNA and p16[ink4a] / Ki-67 detection for improved diagnosis and management of cervical neoplasia in smokers
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2012)Persistent infection with high risk human papillomavirus (HR HPV) is the main etiological agent in the development of cervical cancer. The use of HPV DNA testing in cervical screening programs is becoming increasingly ... -
Regulation of cancer stem cell differentiation by genes and microRNAs
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2012)Since the discovery of a stem cell phenotype in cancer, specific tumour cells with this phenotype, often called cancer stem cells (CSCs), are now widely accepted as the progenitors of oncogenesis, proliferation, treatment ... -
Molecular targeting of HPV oncogenes and oncogenic protein
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2010)Worldwide cervical cancer is the second most common cause of cancer related death in women. Over the last three decades high-risk HPV has been conclusively established as the major etiological factor in cervical cancer and ... -
Non-coding RNA expression in cancer stem cell progenies derived from tumours +/-BRAF V600E mutation
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2013)Cancer has placed a huge burden on the global health system and rising rates in particular cancer types such as lung cancer and melanoma due to smoking and increased UV ray exposure respectively has highlighted the need ... -
MicroRNA profiling in prostate cancer and prostate derived holoclone cell model
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2012)Prostate cancer is a heterogeneous disease and is the most commonly diagnosed malignant tumour and the second most common cause of cancer deaths in western males. Prostate cancer is the most commonly diagnosed cancer in ... -
Developing novel therapeutic approaches in chemoresistant ovarian cancer patients
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2012)Ovarian cancer is the fifth most common cause of cancer death in women and is the leading cause of death from gynaecological malignancy in the Western world. A recent study by the National Cancer Registry, Ireland has shown ... -
Aspirin and P2Y<inf>12</inf> inhibition attenuate platelet-induced ovarian cancer cell invasion
(2015)Background: Platelet-cancer cell interactions play a key role in successful haematogenous metastasis. Disseminated malignancy is the leading cause of death among ovarian cancer patients. It is unknown why different ovarian ... -
Identifying novel hypoxia-associated markers of chemoresistance in ovarian cancer
(2015)Background: Ovarian cancer is associated with poor long-term survival due to late diagnosis and development of chemoresistance. Tumour hypoxia is associated with many features of tumour aggressiveness including increased ... -
Human papillomavirus prevalence in the Irish cervical screening population and a specific group of HIV positive women
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2011)Human Papillomavirus (HPV) is the major aetiological agent in the development of cervical pre-cancer and cancer with high-risk HPV (HR-HPV) types 16 and 18 detected in greater than 70% of squamous cell carcinomas of the ... -
Identification of novel biomarkers in recurrent / chemoresistant ovarian cancer
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2009)The aim of this study was to identify novel biomarkers in recurrent/chemoresistant ovarian cancer, yet an incurable disease. Using cDNA microarrays, we identified distinct patterns of gene expression between primary and ...
