Histopathology & Morbid Anatomy: Recent submissions

Now showing items 41-60 of 106

    • Post-transcriptional Dysregulation by microRNAs is implicated in the Pathogenesis of Gastrointestinal Stromal Tumour [GIST] 

      Kelly, Lorna Catherine-Noelle (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2013)
      In a cohort of 73 GISTs including adult mutant, adult wild-type and paediatric cases miRNA expression was examined using TaqMan® Low Density Arrays (TLDAs), allowing the profiling of 667 miRNAs in a set of two (pool A and ...

    • The p16INK4A pathway in cervical cancer 

      Kehoe, Louise (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2010)
      The p16INK4A protein has been proposed as a biomarker in cervical cancer and pre-cancer. p16INK4A over expression is in contrast to that seen in other cancers, where locus deletion or mutation is the norm. p16INK4A is ...

    • The role of activated RET in papillary tumour morphogenesis 

      Flavin, Richard (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2011)
      RET/PTC rearrangements are initiating events in the development of a significant proportion of papillary thyroid carcinomas. Activated RET/PTC mutations are thought to be restricted to thyroid disease, but in this study ...

    • Molecular algorithms in ovarian serous neoplasia 

      Flavin, Richard (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2009)
      Epithelial ovarian cancer is one of the most common cancers in women and the leading cause of death from gynaecological malignancy in the western world. Approximately 205,000 cases of ovarian cancer are diagnosed worldwide ...

    • Identification, isolation and validation of ovarian cancer stem cells 

      Ffrench, Brendan (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2013)
      Ovarian cancer is often diagnosed at a late stage. Even so, it often responds (~73 %) to first-line therapies. However, the five year survival rate for late stage ovarian cancer is poor (~27 %). It is hypothesised that ...

    • MyD88 : a key regulator of chemoresistance, differentiation and hypoxia resistance in cancer stem cells? 

      Cooke, Aoife (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2013)
      Ovarian cancer, the leading cause of gynaecologic cancer deaths in the western world is characterised by high rates of chemoresistant recurrence. While in primary cases, differentiation status of the tumour is considered ...

    • Differential expression of differentation, key stemness and pathways genes and microRNAs and the role of Tgf-β in embryonal carinoma stem cells 

      Elbaruni, Salah Amru K. (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2010)
      Cancer stem cells (CSCs) identified in multiple malignancies has fuelled the belief that they drive primary tumourigenesis. Their persistence post-intervention contributes to metastasis, recurrence, self-renewal, thus ...

    • Cancer cell-platelet interactions in ovarian cancer metastasis 

      Crowley, Darragh (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2012)
      Ovarian cancer is the leading cause of death from gynaecological malignancy worldwide with an estimated global incidence of 225,900 and mortality of 140,200 per year. In Ireland ovarian cancer is the second most common ...

    • Investigation of oral and oropharyngeal squamous cell carcinoma in young adults 

      O'Regan, Esther (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2006)
      While oral and pharyngeal squamous cell carcinoma is classically a disease of older male smokers, this tumour type can occur in young patients with minimal or no exposure to the traditional risk factors. The prognosis ...

    • Molecular signatures of prostate cancer 

      Murphy, Amanda (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2008)
      Prostate cancer is the second most common cancer in Irish men and the second most common cause of cancer-related deaths. In the United States, there are approximately 234,000 new cases diagnosed every year and 27,350 deaths. ...

    • Development of extraction and analysis of protocols for RNA in formalin-fixed paraffin-embedded (FFPE) materials using TaqMan® real-time PCR 

      Li, Jinghuan (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2009)
      Archival Formalin-Fixed, Paraffin-Embedded (FFPE) tissue samples represent an invaluable source of human tissue for gene expression analysis. They are the most abundant and readily available materials and generally well ...

    • Molecular gene and regulatory profiles in thyroid cancer 

      Denning, Karen (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2009)
      Thyroid carcinoma is the most common endocrine malignancy, with an incidence of approximately eighty cases per year in Ireland and thirty seven thousand cases per year in the United States. While thyroid cancer may be ...

    • Molecular signatures in papillary thyroid carcinoma 

      Cahill, Susanne (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2007)
      Papillary thyroid carcinomas (PTC) are the most frequently occurring type of thyroid malignancy (85%-90%). PTC affects females more frequently than males, with a ratio of 3:1 and can be present in any age group, the mean ...

    • The expression and function of miRNAs in thyroid neoplasia 

      Aherne, Sinéad (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2010)
      Thyroid cancer is the most common endocrine malignancy and accounts for the majority of endocrine cancer deaths each year. Carcinomas of the thyroid comprise a heterogeneous group of neoplasms with distinctive clinical and ...

    • Cancer stemness : unravelling the molecular mechanisms controlling stem cell differentiation and self-renewal 

      Heffron, Cynthia Constance Bridgette Beatrice (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2009)
      Understanding the molecular mechanisms behind cancer cell proliferation and regulation is the key to discovering potential future successful therapies for cancer. The World Health Organisation estimates that 7.6 million ...

    • Endosomal gene expression: a new indicator for prostate cancer patient prognosis? 

      O'LEARY, JOHN; KEEGAN, HELEN; SPILLANE, CATHY (2015)
      Prostate cancer continues to be a major cause of morbidity and mortality in men, but a method for accurate prognosis in these patients is yet to be developed. The recent discovery of altered endosomal biogenesis in prostate ...

    • The MyD88+ phenotype is an adverse prognostic factor in epithelial ovarian cancer. 

      MARTIN, CARA; SHEILS, ORLA; SMYTH, PAUL; FINN, STEPHEN; O'LEARY, JOHN; GALLAGHER, MICHAEL; BATES, MARK; SPILLANE, CATHY (2014)
      The prognosis of epithelial ovarian cancer is poor in part due to the high frequency of chemoresistance. Recent evidence points to the Toll-like receptor-4 (TLR4), and particularly its adaptor protein MyD88, as one potential ...

    • Prevalence of human papillomavirus in men who have sex with men in the era of an effective vaccine; a call to act. 

      SMYTH, PAUL; O'LEARY, JOHN; SHEILS, ORLA (2014)
      OBJECTIVES: The incidence of human papillomavirus (HPV)-associated anal cancer is increasing. Men who have sex with men (MSM), particularly those coinfected with HIV, are disproportionately affected. Documenting the ...

    • Application of statistical process control to qualitative molecular diagnostic assays. 

      O'BRIEN, CATHAL; FINN, STEPHEN (2014)
      Modern pathology laboratories and in particular high throughput laboratories such as clinical chemistry have developed a reliable system for statistical process control (SPC). Such a system is absent from the majority of ...

    • SPINK1 protein expression and prostate cancer progression. 

      Finn, Stephen; Flavin, Richard (2014)
      PURPOSE: SPINK1 overexpression has been described in prostate cancer and is linked with poor prognosis in many cancers. The objective of this study was to characterize the association between SPINK1 overexpression and ...