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Common variant at 16p11.2 conferring risk of psychosis

dc.contributor.authorMORRIS, DEREK
dc.contributor.authorGILL, MICHAEL
dc.date.accessioned2014-03-13T10:22:39Z
dc.date.available2014-03-13T10:22:39Z
dc.date.issued2012
dc.date.submitted2012en
dc.identifier.citationSteinberg S, de Jong S, Mattheisen M, Costas J, Demontis D, Jamain S, Pietilainen OP, Lin K, Papiol S, Huttenlocher J, Sigurdsson E, Vassos E, Giegling I, Breuer R, Fraser G, Walker N, Melle I, Djurovic S, Agartz I, Tuulio-Henriksson A, Suvisaari J, Lonnqvist J, Paunio T, Olsen L, Hansen T, Ingason A, Pirinen M, Strengman E; GROUP, Hougaard DM, Orntoft T, Didriksen M, Hollegaard MV, Nordentoft M, Abramova L, Kaleda V, Arrojo M, Sanjuan J, Arango C, Etain B, Bellivier F, Meary A, Schurhoff F, Szoke A, Ribolsi M, Magni V, Siracusano A, Sperling S, Rossner M, Christiansen C, Kiemeney LA, Franke B, van den Berg LH, Veldink J, Curran S, Bolton P, Poot M, Staal W, Rehnstrom K, Kilpinen H, Freitag CM, Meyer J, Magnusson P, Saemundsen E, Martsenkovsky I, Bikshaieva I, Martsenkovska I, Vashchenko O, Raleva M, Paketchieva K, Stefanovski B, Durmishi N, Pejovic Milovancevic M, Lecic Tosevski D, Silagadze T, Naneishvili N, Mikeladze N, Surguladze S, Vincent JB, Farmer A, Mitchell PB, Wright A, Schofield PR, Fullerton JM, Montgomery GW, Martin NG, Rubino IA, van Winkel R, Kenis G, De Hert M, Rethelyi JM, Bitter I, Terenius L, Jonsson EG, Bakker S, van Os J, Jablensky A, Leboyer M, Bramon E, Powell J, Murray R, Corvin A, Gill M, Morris D, O'Neill FA, Kendler K, Riley B; Wellcome Trust Case Control Consortium 2, Craddock N, Owen MJ, O'Donovan MC, Thorsteinsdottir U, Kong A, Ehrenreich H, Carracedo A, Golimbet V, Andreassen OA, B?rglum AD, Mors O, Mortensen PB, Werge T, Ophoff RA, Nothen MM, Rietschel M, Cichon S, Ruggeri M, Tosato S, Palotie A, St Clair D, Rujescu D, Collier DA, Stefansson H, Stefansson K., Common variant at 16p11.2 conferring risk of psychosis, Molecular Psychiatry, 19, 1, 2012, 108-14en
dc.identifier.otherY
dc.descriptionPUBLISHEDen
dc.description.abstractEpidemiological and genetic data support the notion that schizophrenia and bipolar disorder share genetic risk factors. In our previous genome-wide association study, meta-analysis and follow-up (totaling as many as 18?206 cases and 42?536 controls), we identified four loci showing genome-wide significant association with schizophrenia. Here we consider a mixed schizophrenia and bipolar disorder (psychosis) phenotype (addition of 7469 bipolar disorder cases, 1535 schizophrenia cases, 333 other psychosis cases, 808 unaffected family members and 46?160 controls). Combined analysis reveals a novel variant at 16p11.2 showing genome-wide significant association (rs4583255[T]; odds ratio=1.08; P=6.6 ? 10(-11)). The new variant is located within a 593-kb region that substantially increases risk of psychosis when duplicated. In line with the association of the duplication with reduced body mass index (BMI), rs4583255[T] is also associated with lower BMI (P=0.0039 in the public GIANT consortium data set; P=0.00047 in 22?651 additional Icelanders).en
dc.format.extent108-14en
dc.language.isoenen
dc.relation.ispartofseriesMolecular Psychiatry;
dc.relation.ispartofseries19;
dc.relation.ispartofseries1;
dc.rightsYen
dc.subjectPsychiatryen
dc.titleCommon variant at 16p11.2 conferring risk of psychosisen
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/mgill
dc.identifier.peoplefinderurlhttp://people.tcd.ie/morrisdw
dc.identifier.rssinternalid81874
dc.rights.ecaccessrightsOpenAccess
dc.identifier.urihttp://hdl.handle.net/2262/68286


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