Clinical Medicine: Recent submissions
Now showing items 21-40 of 1003
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Ontology-based integration and querying of heterogeneous rare disease data sources - POLVAS perspective
(2025)The integration of rare disease medical databases belonging to different countries is an important problem, as a large number of observations are required for reliable statistical inference of patient data in order to ... -
Data quality and patient characteristics in European ANCA-associated vasculitis registries: data retrieval by federated querying
(2024)Objectives: This study aims to describe the data structure and harmonisation process, explore data quality and define characteristics, treatment, and outcomes of patients across six federated antineutrophil cytoplasmic ... -
Effect of Immunosuppression on the Immune Response to SARS-CoV-2 Infection and Vaccination.
(2024)Immunosuppressive treatment in patients with rheumatic diseases can maintain disease remission but also increase risk of infection. Their response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination ... -
Emergence of dysfunctional neutrophils with a defect in arginase-1 release in severe COVID-19
(2024)Neutrophilia occurs in patients infected with SARS-CoV-2 (COVID-19) and is predictive of poor outcomes. Here, we link heterogenous neutrophil populations to disease severity in COVID-19. We identified neutrophils with ... -
IFN-gamma-induced trained immunity as a strategy to enhance anti-microbial responses in human monocytes and macrophages.
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2025)Infectious diseases remain a significant global health threat, exacerbated by the rise in multi-drug- resistant infections and the potential for epidemics. Mycobacterium tuberculosis (M.tb) and Staphylococcus aureus are ... -
Investigating the effects of TLR2/MyD88 deficiency in mouse models of age-related macular degeneration
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2025)Age-related macular degeneration (AMD) is the leading cause of blindness among older populations. Despite its global prevalence, a definitive cure for AMD remains elusive. To tackle this, we are focused on modulating the ... -
An Exploration of Cellular Signatures of Ageing, and the Effects of Age-Related Dysregulated Myeloid Circadian Rhythm in Retinal Disease.
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2025)Age-related macular degeneration (AMD) is the most common cause of vision loss and blindness in the elderly population across the developed world. This disease is characterised by a gradual degeneration and death of ... -
Hereditary Haemochromatosis: Hepatic and Cardiac Iron content and cardiac function at baseline and after a treatment course of venesection.
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2025)Background Hereditary haemochromatosis (HH) is the most common inherited genetic disorder in Europe1. Although there are several genetic mutations which can lead to the development of HH, the p.C282Y mutation (tyrosine ... -
The Role of Vascular Ultrasound in GCA-PMR Spectrum Disease
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Background Timely and accurate identification of ‘GCA-PMR Spectrum Disease’ and its subsets is important so vascular complications can be averted. Traditional diagnostic and monitoring tools such as Temporal Artery ... -
The Impact of Driving Restrictions on People with Epilepsy in Ireland
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2025)Driving restrictions have a significant impact on patients with epilepsy and their families. This is documented in international studies but underreported in an Irish context. The goal of this study was to examine this ... -
Type 2 innate lymphoid cells are not involved in mouse bladder tumor development
(2024)Therapies for bladder cancer patients are limited by side effects and failures, highlighting the need for novel targets to improve disease management. Given the emerging evidence highlighting the key role of innate ... -
Gastrointestinal Bleeding Management and Utility of Clinical Scores in Predicting Disease and Outcome in a Modern European Population
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2025)Acute gastrointestinal bleeding remains a significant clinical challenge, with early risk stratification playing a critical role in guiding management decisions and optimizing patient outcomes. Risk scores, particularly ... -
Understanding T cell Immunity in Atopic Dermatitis: Relevance to Staphylococcus aureus Vaccine Design
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2025)In this thesis, I present original research investigating the T cell response to S. aureus in paediatric atopic dermatitis (AD). The aim of this study is to investigate the memory T cell immune response to S. aureus in ... -
Clonal haematopoiesis in telomere biology disorders influences risk of haematological malignancy and overall survival
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Telomere biology disorders (TBD) are a spectrum of diseases caused by germline variants in telomere repair and maintenance. They comprise one of the inherited bone marrow failure syndromes, a heterogenous group of disorders ... -
Inflammatory bowel disease in Ireland : epidemiology of an Irish inception cohort - results from a perspective long-term follow-up study
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2016)Ulcerative Colitis (UC) and Crohn’s Disease (CD) constitute the two main forms of Inflammatory Bowel Disease (IBD). They are chronic relapsing conditions of the gastrointestinal tract with occasional extra-gastrointestinal ... -
Post-genomic investigation of coeliac susceptibility genes
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2017)Coeliac Disease (C) is a debilitating condition characterised by chronic inflammation of the small intestine. This autoimmune disorder is triggered in genetically predispsed individuals following ingestion of dietary gluten, ... -
Polypharmacy and potentially inappropriate prescribing in community dwelling people living with Alzheimer's dementia
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Older adults are the biggest consumers of medications worldwide(1), however they are underrepresented in the clinical literature. This is true also for people living with dementia who are often excluded from clinical ... -
Dysregulated cell signalling as an oncogenic basis for the development of clear cell sarcoma of kidney (CCSK)
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2017)Clear cell sarcoma of the kidney (CCSK) is a poorly understood, aggressive, therapy resistance cancer of childhood. The lack of consistent histological or immunohistochemical features of CCSK can make this a diagnostic ... -
Cancer stem cells : the root of cisplatin resistance in non-small cell lung cancer
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2016)Lung cancer is the leading cause of cancer-related death in Ireland and worldwide. Despite advances in anti-cancer therapies, the overall 5-year survival for non-small cell lung cancer (NSCLC) remains poor (<15%). As such, ... -
Nursing home residents in the Emergency Department (NuHR-ED): a review of resident characteristics and outcomes following Emergency Department attendance and the impact of a Nursing Home Liaison Service
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Introduction: Nursing Home (NH) residents are among the most vulnerable members of society. High rates of multimorbidity, functional dependence and frailty lead to high levels of health and social care needs in this cohort. ...
