School of Pharmacy and Pharmaceutical Sciences: Recent submissions
Now showing items 381-400 of 668
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Investigation of cerebral perfusion changes following MDMA Ecstasy administration in an animal model using bolus-tracking arterial spin labelling MRI
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2012)The recreational drug of abuse 3,4 methylenedioxymethamphetamine (MDMA; Ecstasy) carries a risk of cerebrovascular accidents (CVA) that may relate to the role of serotonin (5- HT) and/or dopamine in the regulation of ... -
The design, implementation, and evaluation of a medication safety programme in an acute Irish teaching hospital
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2011)The research undertaken for this thesis aimed to address the current deficit which exists in relation to the status of medication safety in Irish hospitals and add to the limited body of published data available from any ... -
Platelets decrease chemotherapy -induced cancer cell damage by increasing cell survival : mechanisms and significance
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2010)Cancer cells grow without the restraints of feedback control mechanisms that regulate normal tissue or organ growth, such as apoptosis, leading to Increased cancer cell survival. Deregulation of apoptosis has been Implicated ... -
Preclinical evaluation of novel tumour vasculature disrupting agents
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2013)Targeting of tumour vasculature and angiogenesis represents an ideal approach in the design of cancer therapeutics since all types of solid tumours are dependent upon a blood supply for growth and survival. The best known ... -
RBL-2H3 and primary mast cells and their use in screening novel anti-inflammatory compounds
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2009)Mast cells (MC) have been mainly studied as key effectors in allergic diseases and inflammatory conditions such hypersensitivity reactions, asthma, atopic dermatitis and multiple sclerosis. Following the crosslinkage of ... -
Solid-state characteristics of pre- and post-spray dried active pharmaceutical ingredients, salts and co-crystalline forms
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2011)Salt or co-crystal formation is one of the methods of altering the physicochemical properties of an active pharmaceutical ingredient (API). The drug characteristic can also be changed upon processing. This thesis focused ... -
The synthesis and biochemical evaluation of novel isoquinoline derivatives
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2005)Isoquinolines are naturally occurring alkaloids, some of which have pharmacological activity. Previous work by the research group of Dr. Mary Jane Meegan, has shown diverse classes of isoquinoline derivatives to be active ... -
Hormonal and emotional regulation of memory processes
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2003)This thesis comprises two areas of study. The first study examined the effect of the menstrual cycle on Event-Related Potentials (ERPs) and verbal memory, as measured by paragraph recall and paired associates, and mood, ... -
Assessment of permeability enhancers for salmon calcitonin (sCT) across intestinal cell culture models
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2000)A large number of proteins are now being used or tested as therapeutic agents, enzyme inhibitors or antibodies to combat human disease, therefore they are receiving increased recognition for both their high activity at low ... -
Intestinal degradation and absorption kinetics of salmon calcitonin
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2000)The aim of this work was to investigate the intestinal degradation and absorption of a hydrophilic peptide, salmon calcitonin (sCT), and to evaluate the use of bile salt simple and mixed micellar systems as potential ... -
Pharmaceutical services for patients in methadone treatment in Ireland and the introduction of the Methadone Protocol Scheme
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2002)Methadone is a long-acting opiate commonly used in substitution therapy for heroin addiction. In Ireland, prior to 1998, people requiring treatment for opiate addiction could either attend the National Drug Treatment Centre, ... -
Physiochemical studies of diclofenac salts and the effect of basis excipients on their dissolution
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2001)This study involved investigation of the physicochemical properties of diclofenac salts prepared from a range of organic bases. The salts examined included five novel salts of diclofenac, prepared from the following bases: ... -
Pharmaceutical stability and prodrug studies on the antidepressant bupropion
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2010)This thesis describes the work carried out at the School of Pharmacy and Pharmaceutical Sciences, Trinity College on the pharmaceutical stability and prodrug studies on the antidepressant bupropion. Chapter 1 gives an ... -
Triple negative breast cancer-derived extracellular-vesicles as naturally-occuring biomarkers and therapeutic delivery systems
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2015)Background: In Ireland, breast cancer is the most commonly diagnosed cancer among women; and of the breast cancer subtypes, triple-negative breast cancers (TNBC) are the most aggressive. TNBCs account for 15%-20% of breast ... -
Synthesis, biochemical evaluation and structural studies of novel antiproliferative βeta-lactams
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2010)The synthesis and antiproliferative evaluation of anti-cancer β-lactams targeting tubulin, heat shock protein 90 and the estrogen receptor is described. Compounds were planned to include relevant substituents known to ... -
The production and characterisation of spray dried nanoporous microparticles (NPMPs) intended for dry powder inhalation drug delivery systems
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2008)The focus of the research presented in this thesis was on the potential application of a novel spray drying method to produce excipient-free nanoporous microparticles (NPMPs) of bioactive drug compounds and co-spray dried ... -
Investigations of a spray-drying method for producing nanoporous / nano-particulate microparticles (NPMPs) of proteins and protein-excipient composites
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2009)The research, presented in this thesis, concerns the application of a spray-drying method to produce nanoporous/nano-particulate microparticles (NPMPs) of proteins, stabilising excipients and composites. The proposed method, ... -
Synthesis, characterisation and drug release from a range of novel smart co-biodegrable delivery systems
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2008)In recent years many biodegradable polymers have been investigated particularly for controlled delivery of drugs or proteins/peptides. The most commonly studied biodegradable polymers for controlled drug delivery are based ... -
Production of quinones by in vitro cultures of Dionaea and Streptocarpus species
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2006)Quinones are a class of oxygen-containing secondary metabolites found chiefly in higher plants, fungi, bacteria and restricted in the animal kingdom to arthropods and echinoderms (Thompson 1971). In the plant, quinones, ... -
An investigation into the behavioural effects of polyamines, polyamine antagonsits and novel compounds in vivo
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2007)The polyamines, putrescine, spermidine and spermine are ubiquitous compounents of eukaryotric cells in nature and are found in high concentrations in brain tissue. Polyamines have been implicated in cell growth, differentiation ...
