Trinity College Dublin Theses & Dissertations: Recent submissions
Now showing items 341-360 of 7000
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Towards stem cell regeneration of the nucleus pulposus of the invertebral disc
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2016)Low back pain resulting from intervertebral disc (IVD) degeneration is a significant epidemiological problem and economic burden worldwide. IVD degeneration initiates within the nucleus pulposus (NP), a highly hydrated ... -
Leadership and organisational justice : propostions for improving human resources for health outcomes in the public sector in Uganda - a case for Sub-Sahara Africa
(Trinity College (Dublin, Ireland). School of Psychology, 2016)Background and Justification: The health situation of Africans has been suggested as one of the most critical impediments to the economic development of the region (Kaseje, Juma, & Oindo; 2005). Healthcare workers are ... -
Analytical models of single bubbles and foam
(Trinity College (Dublin, Ireland). School of Physics, 2016)We investigate the use of analytic models of three-dimensional bubbles with deformable surfaces to study the energy of foams in equilibrium. While the idea of modelling the surfaces of bubbles as deformable minimal surfaces ... -
TLR2-dependent type 1 interferon induction in human monocytes and its relevance to Staphylococcus aureus infection
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2016)Even though Staphylococcus aureus is a part of healthy microflora, it is also a significant human pathogen causing mild as well as life-threatening infections. Furthermore, an increasing incidence of antibiotic resistant ... -
Hybrid semiconductor quantum dot / quantum well & metal nanoparticle structures
(Trinity College (Dublin, Ireland). School of Physics, 2016)Non-radiative energy transfer is an energy transfer mechanism based on dipoledipole interactions. It has come to the fore in biomedical imaging and sensing, as well as light emitting and harvesting applications. Utilising ... -
Polypharmacy and potentially inappropriate prescribing in community dwelling people living with Alzheimer's dementia
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Older adults are the biggest consumers of medications worldwide(1), however they are underrepresented in the clinical literature. This is true also for people living with dementia who are often excluded from clinical ... -
Financialisation, West European banking groups and postsocialist transformation in East-Central Europe: Geographies of subnational banking in Croatia
(Trinity College Dublin. School of Natural Sciences. Discipline of Geography, 2024)The overarching aim of this dissertation is to examine the main drivers and manifestations of financialisation in the East-Central European periphery after the collapse of state socialism. To do this, the dissertation takes ... -
Indo-Irish nationalist interactions and the British Empire, 1880 - 1922
(Trinity College (Dublin, Ireland). Department of History, 2017)The primary aim of this thesis is to explore the interaction between the Irish and Indian advanced nationalist movements from 1880 until the establishment of Irish independence in 1922. The study delineates the complex web ... -
Embedding spectrum sharing into LTE-Advanced
(Trinity College (Dublin, Ireland). Department of Electronic & Electrical Engineering, 2016)Society needs more spectrum. It is required to support continuous data growth, a greater number of mobile connections, smarter devices with more powerful computing capabilities and the emergence of new applications/technologics. ... -
Electrophysiological and functional responses to paired associative brain stimulation
(Trinity College (Dublin, Ireland). School of Psychology, 2016)Non invasive brain stimulation (NIBS) methods have exploded in popularity over the last two decades. Despite exhibiting an exponential growth in the number of publications over that period, the field of NIBS research remains ... -
The role of IL-17A in central nervous system autoimmunity
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2017)Multiple sclerosis (MS) is a chronic demyelinating inflammatory disorder of the central nervous system (CNS), involving autoreactive T cell responses to myelin antigens. Experimental autoimmune encephalomyelitis (EAE) is ... -
Quantification of the population dynamics of Pinus and Ulmus in Europe
(Trinity College (Dublin, Ireland). Department of Botany, 2016)This thesis addresses the need to elucidate tree population dynamics at a local and regional scale. Herein tests and develops a variety of methods to quantify tree population dynamics at varying temporal and spatial scales. ... -
Studies on the CNS effects of systemic inflammation induced by dsRNA
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2016)Poly-Inosinic: Poly-Cytidylic Acid (poly I:C) is a synthetic double stranded analogue that contains the main components of a double stranded ribonucleic acid (dsRNA). It is often used in neuroimmunology to mimic the effects ... -
Fundamentalism and international human rights in Islamic constitutions
(Trinity College (Dublin, Ireland). School of Law, 2016)This thesis explores how Islamic states can simultaneously remain faithful to Sharia and Islamic principles of governance, and uphold modern international human rights norms. This presents several distinct analytical ... -
Innate immune regulation of secretory IgA responses
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2016)Owing to its unique biological function, the gastrointestinal tract (GIT) is constitutively exposed to a plethora of antigens including those of dietary and environmental origin. In addition, the enormous bacterial burden ... -
Dysregulated cell signalling as an oncogenic basis for the development of clear cell sarcoma of kidney (CCSK)
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2017)Clear cell sarcoma of the kidney (CCSK) is a poorly understood, aggressive, therapy resistance cancer of childhood. The lack of consistent histological or immunohistochemical features of CCSK can make this a diagnostic ... -
Innate DNA sensing mechanisms and PYHIN protein function in epithelial cell lines
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2016)In the last decade mechanisms for innate immune sensing of pathogens and self nucleic acids have been defined. For cytosolic sensing of DNA, the adaptor protein STING has a central role, operating downstream of DNA sensors ... -
Ecological stability across scales
(Trinity College (Dublin, Ireland). Department of Zoology, 2016)One of the greatest challenges facing ecologists is how to detect and predict species and community responses to disturbance against a background of concurrent and potentially interacting environmental, biotic and anthropogenic ... -
Population genetics of Ancient Western Europe
(Trinity College (Dublin, Ireland). Department of Genetics, 2017)The field of Ancient DNA has been the subject of significant progress during the last decade, shifting from the analysis of a few hundred basepairs to whole-genome data. The main advantage of ancient DNA is the direct ... -
Irish writers and their London publishers c.1884 - 1922
(Trinity College (Dublin, Ireland). School of English, 2016)From the mid-1880s to the First World War, the Anglophone publishing industry, centred in London, experienced an unprecedented period of significant growth and change during which interlocking structural, legal, financial, ...
