Interferon-alpha-induced cognitive and affective impairments : contributions of prefrontal cortex and hippocampal formation

Abstract

Interferon-alpha (IFN-a) is a potent antiviral agent useful in the treatment of many malignancies, but most widely used in the treatment of Hepatitis C. However, sinister adverse events appear as a consequence of IFN-a-treatment. Such side effects include fatigue, fever (‘flu-like’ symptoms) and more serious symptoms such as memory impairments, anxiety, depression and suicidal ideation. Symptoms of major depression present in ~40% of the clinical population taking this drug. The mechanisms underlying these side effects remain elusive; this thesis aims to unravel mechanisms underlying these adverse events.