dc.contributor.advisor | Rossney, Angela | |
dc.contributor.author | Fitzgibbon, Margaret | |
dc.date.accessioned | 2017-01-18T16:18:35Z | |
dc.date.available | 2017-01-18T16:18:35Z | |
dc.date.issued | 2009 | |
dc.identifier.citation | Margaret Fitzgibbon, 'Investigation of reduced susceptibility to glycopeptides among meticillin-resistant Staphylococcus aureus recovered in Ireland (1998-2004)', [thesis], Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Microbiology, 2009, pp 345 | |
dc.identifier.other | THESIS 9261 | |
dc.description.abstract | Meticillin-resistant Staphylococcus aureus (MRSA) isolates (n=3,189) from 2990 patients were studied by agar screening and the E-test™ macromethod to investigate reduced susceptibility to glycopeptides among six collections of MRSA recovered between 1998 and 2004. No vancomycin-resistant S. aureus or glycopeptide-intermediate S. aureus (GISA) were detected but 178 isolates were confirmed by vancomycin population analysis profile (PAP)-area under the curve (vPAP-AUC) ratio determination and/or teicoplanin PAP (tPAP) methods as hetero-GISA (hGISA). Of 139 isolates detected using recommended E-test™ macromethod cut-off values of ≥8 mg/L for both vancomycin and teicoplanin or ≥12 mg/L for teicoplanin alone, 73 were confirmed as hGlSA by vPAP- AUC, 95 by tPAP and 108 by both methods. Lowering the teicoplanin E-test™ macromethod cut-off value to 8 mg/L detected a further 70 hGISA (17 were confirmed by vPAP-AUC and 70 by tPAP). | |
dc.format | 1 volume | |
dc.language.iso | en | |
dc.publisher | Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Microbiology | |
dc.relation.isversionof | http://stella.catalogue.tcd.ie/iii/encore/record/C__Rb14726653 | |
dc.subject | Clinical Microbiology, Ph.D. | |
dc.subject | Ph.D. Trinity College Dublin | |
dc.title | Investigation of reduced susceptibility to glycopeptides among meticillin-resistant Staphylococcus aureus recovered in Ireland (1998-2004) | |
dc.type | thesis | |
dc.type.supercollection | thesis_dissertations | |
dc.type.supercollection | refereed_publications | |
dc.type.qualificationlevel | Doctoral | |
dc.type.qualificationname | Doctor of Philosophy (Ph.D.) | |
dc.rights.ecaccessrights | openAccess | |
dc.format.extentpagination | pp 345 | |
dc.description.note | TARA (Trinity’s Access to Research Archive) has a robust takedown policy. Please contact us if you have any concerns: rssadmin@tcd.ie | |
dc.identifier.uri | http://hdl.handle.net/2262/78982 | |