Mechanical, Manufacturing & Biomedical Eng: Recent submissions
Now showing items 261-280 of 952
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PEDOT:PSS interfaces stabilised using a PEGylated crosslinker yield improved conductivity and biocompatibility.
(2019)The rapidly expanding fields of bioelectronics, and biological interfaces with electronic sensors and stimulators, are placing an increasing demand on candidate materials to serve as robust surfaces that are both biocompatible, ... -
Reinforcing interpenetrating network hydrogels with 3D printed polymer networks to engineer cartilage mimetic composites
(2020)Engineering constructs that mimic the complex structure, composition and biomechanics of the articular cartilage represents a promising route to joint regeneration. Such tissue engineering strategies require the development ... -
Proxy measurement and strategic metering methodologies for resource transparency of industrial systems
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2020)For the latest advancement of manufacturing systems, namely Industry 4.0 or Smart Manufacturing, large amounts of precise process data are required. However, the acquisition of sufficient data represents a challenge for ... -
The development of biomimetic scaffolds for osteochondral tissue engineering
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2020)Articular cartilage (AC) is a soft tissue lining the ends of the bones in our joints. Even minor lesions in AC cause pain, impaired mobility and can develop to osteoarthritis (OA), a disease affecting millions of adults ... -
Development and characterization of corneal substitutes from decellularized tissues
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2020)Diseases affecting the cornea can lead to vision impairment and ultimately to blindness. It is estimated that 45 million people worldwide suffer from corneal blindness. Rejection in high-risk patients and donor shortage ... -
Objective and Quantitative acoustic-analysis of musicians dystonia
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2020)Musician s Dystonia (MD) is the most common movement disorder affecting musicians. Being a specific phenotype of Dystonia, MD is a focal, task-specific and painless disorder that affects motor control during musical ... -
3D bioprinting of cartilage-mimetic implants for biological joint resurfacing
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2020)A major challenge in the field of tissue engineering and regenerative medicine is the development of effective therapies for treating large cartilage or osteochondral defects and ultimately regenerating whole osteoarthritic ... -
The Development of a Novel 3D Bioprinting Strategy to Drive Vascularisation, and its Application for Bone Tissue Engineering
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2020)One of the major challenges facing the field of tissue engineering today is vascularisation. Without a system in place to circulate oxygen, nutrients and metabolites, the size of many tissue engineered constructs is ... -
Self-healing materials: What can nature teach us?
(2017)Natural materials such as bone and insect cuticle are capable of self-repair, a facility that greatly increases their durability and safe working stress. Some engineering materials have also been designed to be self-healing, ... -
Engineering a Corneal Stromal Equivalent Using a Novel Multilayered Fabrication Assembly Technique.
(2020)To overcome the serious shortage of donor corneas for transplantation, alternatives based on tissue engineering need to be developed. Decellularized corneas are one potential alternative, but their densely packed collagen ... -
Designing Scaffolds for Corneal Regeneration
(2020)Corneal blindness is one of the most common causes of vision loss worldwide, affecting millions of people. To treat these patients, researchers have been examining different approaches to engineer corneal scaffolds suitable ... -
Effect of substrate topography on the regulation of human corneal stromal cells.
(2020)Optimal functionality of native corneal stroma depends on a well-ordered arrangement of extracellular matrix (ECM). To develop an in vitro corneal model, replication of the corneal in vivo microenvironment is needed. In ... -
Influence of micropatterned substrates on keratocyte phenotype
(2020)Substrate topographic patterning is a powerful tool that can be used to manipulate cell shape and orientation. To gain a better understanding of the relationship between surface topography and keratocyte behavior, surface ... -
Design of a Kelvin cell acoustic metamaterial
(2020)Advancements in 3D print technology now allow the printing of structured acoustic absorptive materials at appropriate microscopic scales and sample sizes. Optimisation of parameter sets associated with a Kelvin Cell structure ... -
Adaptive Liquid Cooling Methods in Microchannel Heat Sinks
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2020)This work investigates the effect of implementing three varying cooling techniques for high heat flux electronics cooling. High heat fluxes are being experienced in data centres as the number of transistors per inch increases ... -
Design and optimisation of focused infrared heating devices
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2020) -
Pedestrian whole body ground contact mechanisms and head injury assessment following vehicle impact
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2020)According to the WHO, there are an estimated 1.35 million road-traffic related deaths each year, with pedestrians constituting approximately 22% of this figure, which justifies the necessity of research into vehicle-pedestrian ... -
Mechanisms of heat transfer for axisymmetric bubble impingement and rebound
(2017)Heat transfer enhancement resulting from the impingement and rebound of bubbles in confined geometries can play an important role in heat transfer applications. Limited studies exist on the impact behavior of large ellipsoidal ... -
Biomechanical studies of feline ventral abdominal wall and celiotomy closure techniques.
(2018)Objective: To compare biomechanical properties and mechanism of failure of 3 regions of ventral abdominal wall in cats by using 2 suture materials, 2 suture bite‐to‐stitch intervals (SBSI), and full‐thickness versus ... -
The Role of Macrophages in the Infarcted Myocardium: Orchestrators of ECM Remodeling.
(2019)Myocardial infarction is the most common form of acute cardiac injury attributing to heart failure. While there have been significant advances in current therapies, mortality and morbidity remain high. Emphasis on inflammation ...
