Mechanical, Manufacturing & Biomedical Eng: Recent submissions
Now showing items 281-300 of 952
-
The rationale and emergence of electroconductive biomaterial scaffolds in cardiac tissue engineering.
(2019)The human heart possesses minimal regenerative potential, which can often lead to chronic heart failure following myocardial infarction. Despite the successes of assistive support devices and pharmacological therapies, ... -
Multipotent vascular stem cells and the effects of cyclic tensile strain, collagen structure and stenting on medial vascular cell populations
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2020)Atherosclerosis is one of the leading causes of mortality worldwide, and presents as a narrowing or occlusion of an artery. Interventions to re-open the arterial lumen can result in re-occlusion through intimal hyperplasia. ... -
Local Heat Transfer to an Evaporating Sessile Droplet in an Electric Field
(2016)Local heat transfer of an evaporating sessile droplet under a static electric field is an underdeveloped topic. In this research an 80 μl water droplet is placed in the centre of a 25 μm thick stainless steel substrate. A ... -
Cold spraying of WC-Co-Ni coatings using porous WC-17Co powders
(2017)Cold spray has been successfully used to produce WC-Co coatings in recent years, showing great potential. However, due to the lack of sufficient Comatrix phase for plastic deformation, the ... -
Nozzle-internal particle velocity measurements and loading effect on particle acceleration inside a Cold Spray nozzle
(2017)The advantages of the solid state deposition process Cold Spray (CS) over conventional spray technologies go hand in hand with the requirement of high and well-predictable particle velocities. The ... -
On effect of primed cellular microcapsules and pH neutralizing biomaterials to augment regeneration of the intervertebral disc
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2020)One of the most common topics of research worldwide for medical health care is low back pain (LBP). It is widely accepted that LBP is associated with degeneration of the intervertebral disc (IVD), the shock absorbent soft ... -
Manufacture of Reflective Aluminium Surfaces Using Cold Spray
(ASM International, 2018)This research demonstrates the use of cold spray (CS) as an additive manufacturing process to manufacture reflective aluminium coatings. Nitrogen was used as a carrier gas at various gas heating temperatures. Following ... -
New Insights into the Formation Mechanism of Intertwining Interfaces in Cold Spray
(ASM International, 2018)Experimental investigation supported by numerical modeling was conducted to explore the formation mechanism of intertwining interface in cold spray. The result revealed that low particle impact velocity and the consequent ... -
Electroconductive Melt Electrowritten Patches Matching the Mechanical Anisotropy of Human Myocardium
(2020)Cardiac patches represent a promising strategy for the treatment of myocardial infarction (MI). Here, an electroconductive cardiac patch that conforms to the mechanics of human myocardium is fabricated. By melt electrospinning ... -
A deeper understanding of intestinal organoid metabolism revealed by combining fluorescence lifetime imaging microscopy (FLIM) and extracellular flux analyses.
(2020)Stem cells and the niche in which they reside feature a complex microenvironment with tightly regulated homeostasis, cell-cell interactions and dynamic regulation of metabolism. A significant number of organoid models has ... -
Collagen fibre orientation and dispersion govern ultimate tensile strength, stiffness and the fatigue performance of bovine pericardium
(2019)The durability of bovine pericardium leaflets employed in bioprosthetic heart valves (BHVs) can significantly limit the longevity of heart valve prostheses. Collagen fibres are the dominant load bearing component of bovine ... -
Hypoxia mimicking hydrogels to regulate the fate of transplanted stem cells
(2019)Controlling the phenotype of transplanted stem cells is integral to ensuring their therapeutic efficacy. Hypoxia is a known regulator of stem cell fate, the effects of which can be mimicked using hypoxia-inducible factor ... -
Osteoarthritis-associated basic calcium phosphate crystals alter immune cell metabolism and promote M1 macrophage polarization
(2019)Objective: A number of studies have demonstrated that molecules called ‘alarmins’ or danger-associated molecular patterns (DAMPs), contribute to inflammatory processes in the OA joint. Metabolic reprog-ramming of immune ... -
Biofabrication of spatially organised tissues by directing the growth of cellular spheroids within 3D printed polymeric microchambers
(2019)Successful tissue engineering requires the generation of human scale implants that mimic the structure, composition and mechanical properties of native tissues. Here, we report a novel biofabrication strategy that enables ... -
Enhanced corrosion resistance and cytocompatibility of biomimetic hyaluronic acid functionalised silane coating on AZ31 Mg alloy for orthopaedic applications.
(2018)This paper reports the corrosion resistant and cytocompatible properties of the hyaluronic acid-silane coating on AZ31 Mg alloy. In this study, the osteoinductive properties of high molecular weight hyaluronic acid (HA, ... -
Biomimetic Hyaluronic Acid-Lysozyme Composite Coating on AZ31 Mg Alloy with Combined Antibacterial and Osteoinductive Activities
(2017)This study presents the covalent grafting of a hyaluronic acid-lysozyme (HA-LZ) composite onto corrosion-resistant silane-coated AZ31 Mg alloy via EDC-NHS coupling reactions. The HA-LZ composite coatings created a smooth ... -
Integrating finite element modelling and 3D printing to engineer biomimetic polymeric scaffolds for tissue engineering
(2019)The suitability of a scaffold for tissue engineering is determined by a number of interrelated factors. The biomaterial should be biocompatible and cell instructive, with a porosity and pore interconnectivity that facilitates ... -
Fiber Reinforced Cartilage ECM Functionalized Bioinks for Functional Cartilage Tissue Engineering
(2019)Focal articular cartilage (AC) defects, if left untreated, can lead to debilitating diseases such as osteoarthritis. While several tissue engineering strategies have been developed to promote cartilage regeneration, it ... -
Influence of polydimethylsiloxane substrate stiffness on corneal epithelial cells
(2019)Many cell types are known to modulate their behaviour in response to changes in material stiffness; however, little is known about how stiffness affects corneal epithelial cells. This study aims to investigate the response ... -
Biofabrication of multiscale bone extracellular matrix scaffolds for bone tissue engineering
(2019)Interconnected porosity is critical to the design of regenerative scaffolds, as it permits cell migration, vascularisation and diffusion of nutrients and regulatory molecules inside the scaffold. 3D printing is a promising ...
