Mechanical, Manufacturing & Biomedical Eng: Recent submissions
Now showing items 301-320 of 952
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Biomaterial-based endochondral bone regeneration: A shift from traditional tissue engineering paradigms to developmentally inspired strategies
(2019)There is an urgent, clinical need for an alternative to the use of autologous grafts for the ever increasing number of bone grafting procedures performed annually. Herein, we describe a developmentally inspired approach ... -
Glyoxal cross-linking of solubilized extracellular matrix to produce highly porous, elastic, and chondro-permissive scaffolds for orthopedic tissue engineering
(2019)Extracellular matrix (ECM)-derived implants hold great promise for tissue repair, but new strategies are required to produce efficiently decellularized scaffolds with the necessary porosity and mechanical properties to ... -
Teaching Innovation in Interdisciplinary Environments: Toward a Design Thinking Syllabus
(2018)An increasing number of universities offer user-centric innovation courses based on the principles of design thinking. Lecturers combine a plethora of design thinking elements in design thinking course syllabi and thereby ... -
Tissue-specific extracellular matrix scaffolds for the regeneration of spatially complex musculoskeletal tissues
(2019)Biological scaffolds generated from tissue-derived extracellular matrix (ECM) are commonly used clinically for soft tissue regeneration. Such biomaterials can enhance tissue-specific differentiation of adult stem cells, ... -
The use of small angle light scattering in assessing strain induced collagen degradation in arterial tissue ex vivo
(2018)Collagen is the predominant load bearing component in many soft tissues including arterial tissue and is therefore critical in determining the mechanical integrity of such tissues. Degradation of collagen fibres is ... -
Unravelling the role of mechanical cues on the chondrogenic differentiation of stem cells
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2019)The inability of adult articular cartilage to regenerate has motivated the development of tissue engineering strategies to repair cartilage defects before they progress to osteoarthritis. Common cell based strategies ... -
Electrospun Poly-D-L-lactic acid fibrous scaffolds as a delivery vehicle for calcium phosphate salts to promote in situ mineralisation and bone regeneration
(2018)Polymeric scaffolds and calcium phosphate cements have both shown promise in treating bone defects, whereby the former facilitates cell-mediated repair over long periods, while the latter facilitates rapid defect filling ... -
Pressure-induced mesenchymal stem cell osteogenesis is dependent on intermediate filament remodeling.
(2019)Macroscale loading of bone generates a complex local mechanical microenvironment that drives osteogenesis and bone mechanoadaptation. One such mechanical stimulus generated is hydrostatic pressure (HP); however, the effect ... -
The effect of pore size within fibrous scaffolds fabricated using melt electrowriting on human bone marrow stem cell osteogenesis.
(2019)Limitations associated with current bone grafting materials has necessitated the development of synthetic scaffolds that mimic the native tissue for bone repair. Scaffold parameters such as pore size, pore interconnectivity, ... -
The impact of decellularization methods on extracellular matrix derived hydrogels.
(2019)Tissue-derived decellularized biomaterials are ideal for tissue engineering applications as they mimic the biochemical composition of the native tissue. These materials can be used as hydrogels for cell encapsulation and ... -
Potential for combined delivery of riboflavin and all-trans retinoic acid, from silk fibroin for corneal bioengineering.
(2019)Millions of people worldwide suffer from vision impairing conditions resulting from corneal injury or disease. Silk fibroin (SF) is an emerging biopolymer that has been used for several applications including the fabrication ... -
Characterization of extracellular matrix modified poly(¿-caprolactone) electrospun scaffolds with differing fiber orientations for corneal stroma regeneration
(2020)Alternatives to donor cornea transplantation based on tissue engineering are desirable to overcome the current severe donor tissue shortage. Many natural polymers have good biological properties but poor mechanical properties ... -
On-site renewable electricity production and self consumption for manufacturing industry in Ireland: Sensitivity to techno-economic conditions
(2019)The technical and economic feasibility of on-site renewable energy production from solar and wind for a specific manufacturing plant in Ireland is assessed. The energy load of the plant during a typical year is identified ... -
Micromechanical modelling of normal, drug treated and osteoporotic bone using scanning acoustic microsopy and finite element analysis
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2011)Ultrasonic methods were exclusively used to image cortical bone at high resolutions. A scanning acoustic microscope was used at a frequency of 150 MHz giving a resolution of 20μm. Images were taken of ovine bone samples ... -
The influence of scoliosis and wheechair customisations in rear impact
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2009)Considerable advances in wheelchair occupant frontal impact safety have been achieved, but further research in rear impact is required. Future analysis would benefit from more biofidelic representation of wheelchair ... -
Simulation of microcrack growth and repair in living bone
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2013)As they are the structural components of the body, bones are subjected to the accumulation of damage because of cyclical stress (fatigue). The fatigue damage in bone takes the form of microscopic cracks (microcracks) that ... -
The effect of mechanical cues on the chondrogenic differentiation of bone marrow derived mesenchymal stem cells
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2012)Tissue engineering strategies utilising mesenchymal stem cells (MSCs) represent a promising treatment option for a range of injuries and diseases. If MSCs are to be implanted in vivo, understanding the intricacies of how ... -
The characterisation of electrical energy consumption in complex manufacturing process chains
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2013)The combination of increasing energy costs, corporate image concerns, and environmental legislation is driving a transition towards energy and resource efficiency within the manufacturing sector. Developing a more comprehensive ... -
Heat transfer behaviour of a dilute impinging air-water mist jet
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2015)While the convective heat transfer characteristics of conventional air jets have received a large amount of attention, mist Jets remain relatively under-represented within the literature. The mist jet has the potential to ... -
Composite scaffold development and bioreactor culture for bone tissue engineering
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2009)Bone tissue engineering involves seeding bone cells onto a scaffold, culturing this construct so that mineralisation occurs (by using signalling mechanisms such as growth factors or bioreactors) and then implanting it into ...
