Genetics: Recent submissions
Now showing items 121-140 of 578
-
Faster Evolving Primate Genes Are More Likely to Duplicate
(2018)An attractive and long-standing hypothesis regarding the evolution of genes after duplication posits that the duplication event creates new evolutionary possibilities by releasing a copy of the gene from constraint. Apparent ... -
An Exploration of Mitochondrially Targeted Gene Therapies for Ocular Disorders
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2020)Mitochondria play a vital role in numerous fundamental processes of the cell such as ATP synthesis, cellular signalling, reactive oxygen species production, calcium regulation and apoptosis to name but a few. Given their ... -
IL-33 deficiency causes persistent inflammation and severe neurodegeneration in retinal detachment
(2019)Background: Interleukin-33 (IL-33) belongs to the IL-1 cytokine family and resides in the nuclei of various cell types. In the neural retina, IL-33 is predominately expressed in Müller cells although its role in health ... -
Tight junctions of the outer blood retina barrier
(2020)The outer blood retina barrier (oBRB) formed by the retinal pigment epithelium (RPE) is critical for maintaining retinal homeostasis. Critical to this modified neuro-epithelial barrier is the presence of the tight junction ... -
Ancient pigs reveal a near-complete genomic turnover following their introduction to Europe
(2019)Archaeological evidence indicates that pig domestication had begun by ∼10,500 y before the present (BP) in the Near East, and mitochondrial DNA (mtDNA) suggests that pigs arrived in Europe alongside farmers ∼8,500 y BP. A ... -
Blood-brain barrier response in the context of sports-related TBI
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2020)Traumatic brain injury (TBI) is one of the largest causes of mortality and disability globally. The severity of TBI is clinically categorised into mild, moderate and severe injuries. Moderate and severe TBI often present ... -
PRC2 functions in development and congenital disorders
(2019)Polycomb repressive complex 2 (PRC2) is a conserved chromatin regulator that is responsible for the methylation of histone H3 lysine 27 (H3K27). PRC2 is essential for normal development and its loss of function thus results ... -
Dangerous Liaisons: Interplay between SWI/SNF, NuRD and Polycomb in Chromatin Regulation and Cancer.
(2019)Changes in chromatin structure mediated by ATP-dependent nucleosome remodelers and histone modifying enzymes are integral to the process of gene regulation. Here, we review the roles of the SWI/SNF (switch/sucrose ... -
Origins and genetic legacies of the Caribbean Taino
(2018)Ancient DNA has revolutionized the field of archaeology, but in the Caribbean and other tropical regions of the world, the work has been hampered by poor DNA preservation. We present an ancient human genome from the Caribbean ... -
The york gospels: A 1000-year biological palimpsest
(2017)Medieval manuscripts, carefully curated and conserved, represent not only an irreplaceable documentary record but also a remarkable reservoir of biological information. Palaeographic and codicological investigation can ... -
The population genomics of archaeological transition in west Iberia: Investigation of ancient substructure using imputation and haplotype-based methods
(2017)We analyse new genomic data (0.05–2.95x) from 14 ancient individuals from Portugal distributed from the Middle Neolithic (4200–3500 BC) to the Middle Bronze Age (1740–1430 BC) and impute genomewide diploid genotypes in ... -
Genome-wide data from two early Neolithic East Asian individuals dating to 7700 years ago
(2017)Ancient genomes have revolutionized our understanding of Holocene prehistory and, particularly, the Neolithic transition in western Eurasia. In contrast, East Asia has so far received little attention, despite ... -
Activation of the PhoPR-mediated response to phosphate limitation is regulated by wall teichoic acid metabolism in Bacillus subtilis
(2018)Phosphorous is essential for cell viability. To ensure an adequate supply under phosphate limiting conditions, bacteria induce a cohort of enzymes to scavenge for phosphate, and a high affinity transporter for its uptake ... -
Iron regulated surface determinants of Staphylococcus aureus and S. lugdunensis : their roles in pathogen-host interactions
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2013)Staphylococcus aureus is a human pathogen that causes invasive infections. The ability to internalize into and persist within host cells is thought to contribute to pathogenesis. The study described here has identified a ... -
Dissecting the functional link between transcription factor codes and axon guidance genes in Drosophila motor neurons
(Trinity College (Dublin, Ireland). Department of Genetics, 2013)As axons navigate through the extracellular environment they are exposed to different guidance cues that will steer them when sensed by receptors and cell adhesion molecules [CAMS) present on their membranes. The intricate ... -
A functional genomics approach to study plant reproductive development
(Trinity College (Dublin, Ireland). Department of Genetics, 2012)A fundamental question in developmental biology is how differentiated cell types and organs are formed from undifferentiated precursor cells. The establishment of the body plan of an organism is ultimately defined by its ... -
The evolution of molecular chaperones and their clients
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2011)Molecular chaperones are ancient and ubiquitous proteins that help other proteins in the cell to fold. In this thesis, we investigate the evolution of assisted protein folding from two perspectives: the evolution of the ... -
Caspase and granzyme regulated events in apoptosis and inflammation
(Trinity College (Dublin, Ireland). Department of Genetics, 2011)The caspase and granzyme proteases are key regulators of both programmed cell death (apoptosis) and inflammation. They achieve this regulation through the limited proteolysis of protein substrates, this has the consequence ... -
Unravelling the evolutionary complexity of RNA viruses
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2009)Viruses are a delicate group of organisms renowned for the serious diseases they inflict. They affect all cellular life and are subdivided into RNA-based and DNA-based viruses depending on the type of genomic nucleotide ... -
Expression of antibody fragments in tobacco using transient and stable expression systems
(Trinity College (Dublin, Ireland). Department of Genetics, 2011)Plants are an attractive alternative to mammalian and microbial cell culture systems as a potential production platform for recombinant proteins. Apart from avoiding ethical problems associated with transgenic animals, ...
