Genetics: Recent submissions

Now showing items 221-240 of 578

    • Towards a gene therapy for RP10 retinitis pigmentosa 

      Tam, Lawrence Chi Shing (Trinity College (Dublin, Ireland). Department of Genetics, 2008)
      The main focus of this thesis is on the development of a gene therapy strategy using RNAi-mediated suppression for the RP10 form of retinitis pigmentosa (RP), which accounts for approximately 2% of all autosomal dominant ...

    • Comparative genomics in yeasts 

      Wong, Simon (Trinity College (Dublin, Ireland). Department of Genetics, 2004)
      Comparative genomics allows us to delve into the fundamental differences among species that form the basis of biodiversity, as well as the preservative forces of natural selection that have left many things unchanged. It ...

    • An examination of Serotonergic candidate genes in Attention Deficit Hyperactivity Disorder 

      Sheehan, Karen (Trinity College (Dublin, Ireland). Department of Genetics, 2008)
      Attention Deficit Hyperactivity Disorder (ADHD) is a common, highly heritable childhood disorder. It is characterised by symptoms of inattention, hyperactivity, and impulsivity. Heritability of ADHD is estimated to be ...

    • Going fast and getting lost : gene duplication in yeast 

      Scannell, Devin (Trinity College (Dublin, Ireland). Department of Genetics, 2007)
      In this thesis I study how duplicate gene pairs created by a whole-genome duplication in an ancestor of several yeast species were resolved. I show that gene duplication may lead not just to the emergence of new gene ...

    • The double-edged complexity of molecular sequence evolution 

      Rubio, Valentín Ruano (Trinity College (Dublin, Ireland). Department of Genetics, 2008)
      Traditionally, phylogenetic studies based on sequence data assume simple models of evolution. This is due to computational and time constraints and to our incomplete understanding of the actual complexity of the evolutionary ...

    • On the genetics of retinal function and disease 

      Reynolds, Alison Louise (Trinity College (Dublin, Ireland). Department of Genetics, 2006)
      There are many recorded examples in which genetic background has been shown to radically influence retinal phenotypes in inbred mouse strains. For example, the manifestations of a targeted knockout of the p53 gene are much ...

    • Genetic variation in the bovine genome : signatures of selection and demographic history 

      Murray, Caitríona (Trinity College (Dublin, Ireland). Department of Genetics, 2008)
      Domestication, and its associated environmental and demographic changes, undoubtedly brought new challenges to early domesticates, such as cattle. One of the most important would have been the emergence of new disease ...

    • Y chromosomes and Irish phylogeography 

      Moore, Laoise Teresa (Trinity College (Dublin, Ireland). Department of Genetics, 2005)
      A High-Resolution Y Chromosome Survey of Ireland. In order to investigate the origins of the Irish population and to describe the population genetic events that have shaped the extant Irish gene pool, Y chromosome genetic ...

    • Exploration of a therapeutic strategy for osteogenesis imperfecta 

      McMahon, Helena (Trinity College (Dublin, Ireland). Department of Genetics, 2007)
      The studies described in this thesis focus upon an RNAi-base therapeutic approach for the treatment of Col1A1 linked Osteogenesis Imperfecta (OI). OI is an autosomal dominant negative disorder in w hich the presence of ...

    • Mitochondrial genes associated with cytoplasmic male sterility in Lolium perenne 

      McDermott, Paul (Trinity College (Dublin, Ireland). Department of Genetics, 2008)
      This study involved molecular investigations of cytoplasmic male sterility (CMS) in perennial ryegrass (Lolium perenne L). The CMS line originated as an interspecific hybrid between L. perenne (male parent) and Festuca ...

    • Cell signalling and ADP ribosylation factor 1 (Arf1) effector proteins of African trypanosomes 

      McAndrew, Miriam (Trinity College (Dublin, Ireland). Department of Genetics, 2008)
      The control of population size and differentiation status is essential for the survival of all organisms. Tight regulation of these processes is of particular importance for parasites. The African trypanosome, Trypanosoma ...

    • Examinations of DRD4, DRD5 and SNAP-25 as candidate genes in Attention Deficit Hyperactivity Disorder 

      Lowe, Naomi Temple (Trinity College (Dublin, Ireland). Department of Genetics, 2005)
      Attention deficit hyperactivity disorder (ADHD) is a common early onset childhood disorder. Symptoms o f the disorder include inattentiveness, impulsiveness, distractibility and hyperactivity. Family, twin and adoption ...

    • Characterization of two flowering gene homologues from Lolium perenne 

      Hayes, James (Trinity College (Dublin, Ireland). Department of Genetics, 2005)
      Lolium perenne (perennial ryegrass) is a primary source of fodder for grazing cattle and is therefore of significant agricultural and economic importance. Understanding the flowering process in this species may help to ...

    • Genomic evolution of polyploid yeast species 

      Gordon, Jonathan (Trinity College (Dublin, Ireland). Department of Genetics, 2008)
      In Chapter 2 of this thesis I study how the genome structure and content of yeast has evolved since a Whole Genome Duplication (WGD) occurred in the lineage approximately 100 million years ago. By using genome data from ...

    • Evolutionary genomics of filamentous fungi 

      Khaldi, Nora (Trinity College (Dublin, Ireland). Department of Genetics, 2008)
      Filamentous fungi are important producers of secondary metabolites (SMs), together with plants and bacteria. While some SMs are toxic to humans, animals or plants, many others are beneficial. The discovery that the genes ...

    • Therapeutic stratagems for dominant genetic disorders 

      Kernan, Fiona (Trinity College (Dublin, Ireland). Department of Genetics, 2006)
      Autosomal dominant genetic diseases exhibit a phenotype when one gene allele is mutated whereas recessive diseases require both alleles to be mutated for disease pathology to arise. Disease alleles inherited in a dominant ...

    • Studies on Irish families with autosomal dominant retinitis pigmentosa, congenital stationary night blindness and on mouse models of inherited retinopathies 

      Kenna, Paul F. (Trinity College (Dublin, Ireland). Department of Genetics, 2007)
      This thesis describes over 17 years of research into the molecular genetics of inherited retinopathies including Retinitis Pigmentosa (RP), the most prevalent form of inherited blindness world-wide, and Congenital Stationary ...

    • Bovini mitochondrial DNA : demographic history and recombination 

      Finlay, Emma (Trinity College (Dublin, Ireland). Department of Genetics, 2006)
      Bovini mitochondrial sequences were analysed at levels from intra-population studies to inter-species analyses. D-loop sequences were analysed to draw conclusions about the domestication of water buffalo and the demographic ...

    • Role of CED-9/cl-2 family proteins in mitochondrial fission and fusion dynamics 

      Delivani, Petrina (Trinity College (Dublin, Ireland). Department of Genetics, 2008)
      Programmed cell death in the nematode C. elegans is the equivalent process to human apoptosis. Studying this process in the model organism has led to a great amount of knowledge about the details of pathway steps and ...

    • Effect of gene structure changes on the rate of protein sequence evolution 

      Cusack, Brian (Trinity College (Dublin, Ireland). Department of Genetics, 2007)
      The elaborate architecture of the genes of niulticellular eukaryotes is likely to underpin the unique complexity of eukaryotic gene functions. The structure of eukaryotic genes differs from that of prokaryotes and represents ...