Genetics: Recent submissions
Now showing items 281-300 of 578
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The blood-brain barrier in neuropsychiatric disorders
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2018)Schizophrenia is a severe and disabling mental disorder that affects approximately 1% of the population. Such is the heterogeneous nature of the disease that genetic, neurobiological and environmental factors all contribute ... -
Motor axon guidance in Drosophila
(2019) -
Targeting the tight-junctions of the conventional outflow pathway in primary open-angle glaucoma.
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2018)Primary open-angle glaucoma (POAG) is one of the leading causes of blindness worldwide, affecting an estimated 44.1 million people (Tham et al. 2014). POAG is characterised by elevated intraocular pressure (IOP) due to ... -
Investigation of the PhoPR two-component signal transduction system in Bacillus subtilis, Staphylococcus aureus and Staphylococcus epidermidis
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2018)Investigation of the PhoPR two-component signal transduction system in Bacillus subtilis, Staphylococcus aureus and Staphylococcus epidermidis. Michael Prunty The PhoPR two-component signal transduction system (TCS) ... -
Tight junctions of blood-brain barrier in Alzheimer's disease
(Trinity College (Dublin, Ireland). Department of Genetics, 2015)Located along the brain endothelium, the blood-brain barrier (BBB) is essential for regulating the exchange of ions and macromolecules between the blood circulation and neural tissue and restricting brain entry of potentially ... -
Inflammatory consequences of divergent cell death signals
(Trinity College (Dublin, Ireland). Department of Genetics, 2015)Tumor Necrosis Factor (TNF) is an apical cytokine that drives inflammation through triggering the synthesis and secretion of multiple downstream pro-inflammatory cytokines and chemokines. Generally, TNF stimulation does ... -
Persistent, ancient constraints shape copy number and expression variation of dosage-sensitive genes
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2017)