Genetics: Recent submissions
Now showing items 301-320 of 578
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Control of floral meristem activity in the model plant Arabidopsis thaliana
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2017)Over the past 30 years, the flower development has been one of the main model to study the genetic control of organogenesis in higher plants. The work on Arabidopsis thaliana has led to the proposal of the ABC model of ... -
MicroRNA regulation of the bovine alveolar macrophage response to Mycobacterium bovis
(Trinity College (Dublin, Ireland). Department of Genetics, 2015)Bovine tuberculosis is one of the most economically significant infectious diseases of cattle in Ireland and globally, resulting in economic losses of approximately €2 billion annually. The causative agent is Mycobacterium ... -
Genetics of calving performance
(Trinity College (Dublin, Ireland). Department of Genetics, 2015)Calving performance is a significant contributor to the profitability of cattle production systems whilst also becoming an increasingly important welfare issue in recent years. Calving performance includes both dystocia ... -
Sterile inflammation and age-related macular degeneration
(Trinity College (Dublin, Ireland). Department of Genetics, 2015)Age-related macular degeneration (AMD) is the leading cause of legal blindness in elderly individuals in the developed world, estimated to affect 196 million people worldwide by 2020 (Wong et ai, 2014). AMD primarily affects ... -
Modulating oxidative stress in the retina using gene therapy as a potential treatment for inherited retinopathies
(Trinity College (Dublin, Ireland). Department of Genetics, 2014)The focus of this thesis was the exploration of genetic modulators of oxidative stress in transgenic mouse models of Retinitis Pigmentosa (RP). This disease can be inherited both dominantly and recessively and can be either ... -
Reverse signaling by semaphorin-6A regulates cellular aggregation and neuronal morphology
(2016)The transmembrane semaphorin, Sema6A, has important roles in axon guidance, cell migration and neuronal connectivity in multiple regions of the nervous system, mediated by context-dependent interactions with plexin receptors, ... -
A genome-wide resource for the analysis of protein localisation in Drosophila
(2016)The Drosophila genome contains >13000 protein-coding genes, the majority of which remain poorly investigated. Important reasons include the lack of antibodies or reporter constructs to visualise these proteins. Here, we ... -
The genetics of amyotrophic lateral sclerosis
(Trinity College (Dublin, Ireland). Department of Genetics, 2013)Amyotrophic lateral sclerosis, commonly referred to as motor neuron disease or simply ALS, is a neurological disorder which involves the degeneration of upper and lower motor neurons. The disease is associated with a ... -
The interplay between cell death and inflammation
(Trinity College (Dublin, Ireland). Department of Genetics, 2015)The connection between cell death and inflammation is an ancient one, first documented in the first century AD by the roman physician Galen. Cell death, as a consequence of tissue injury or infection, is a potent and ... -
The Chromodomain Helicase DNA binding protein CHD5 is required for neuronal differentiation and repression of non neuronal genes
(Trinity College (Dublin, Ireland). Department of Genetics, 2012)The candidate tumour suppressor gene chromodomain, helicase DNA-binding protein 5 (CHD5) is frequently deleted in neuroblastoma. However, little is known about the role of the CHD5 protein during normal development or its ... -
Efficient gene delivery to photoreceptors using AAV2/rh10 and rescue of the Rho�^'/�^' mouse
(2015)As gene therapies for various forms of retinal degeneration progress toward human clinical trial, it will be essential to have a repertoire of safe and efficient vectors for gene delivery to the target cells. Recombinant ... -
Targeting the NLRP3 inflammasome in chronic inflammatory diseases: Current perspectives
(2015)The inflammasome is a molecular platform formed by activation of an innate immune pattern recognition receptor seed, such as NLRP3. Once activated, NLRP3 recruits the adapter ASC (apoptosis-related speck-like protein ... -
Gene dosage in the dysbindin schizophrenia susceptibility network differentially affect synaptic function and plasticity
(2015)Neurodevelopmental disorders arise from single or multiple gene defects. However, the way multiple loci interact to modify phenotypic outcomes remains poorly understood. Here, we studied phenotypes associated with mutations ... -
The phenotypic plasticity of duplicated genes in Saccharomyces cerevisiae and the origin of adaptations
(2017)Gene and genome duplication are the major sources of biological innovations in plants and animals. Functional and transcriptional divergence between the copies after gene duplication has been considered the main driver of ... -
Essentiality is a strong determinant of protein rates of evolution during mutation accumulation experiments in Escherichia coli
(2016)The Neutral Theory of Molecular Evolution is considered the most powerful theory to understand the evolutionary behavior of proteins. One of the main predictions of this theory is that essential proteins should evolve ... -
The molecular chaperone dnak is a source of mutational robustness
(2016)Molecular chaperones, also known as heat-shock proteins, refold misfolded proteins and help other proteins reach their native conformation. Thanks to these abilities, some chaperones, such as the Hsp90 protein or the ... -
Recent positive selection has acted on genes encoding proteins with more interactions within the whole human interactome
(2015)Genes vary in their likelihood to undergo adaptive evolution. The genomic factors that determine adaptability, however, remain poorly understood. Genes function in the context of molecular networks, with some occupying ... -
A whole mitochondria analysis of the Tyrolean Iceman's leather provides insights into the animal sources of Copper Age clothing
(2016)The attire of the Tyrolean Iceman, a 5,300-year-old natural mummy from the Ötzal Italian Alps, provides a surviving example of ancient manufacturing technologies. Research into his garments has however, been limited by ... -
A genome-wide association study for genetic susceptibility to Mycobacterium bovis infection in dairy cattle identifies a susceptibility QTL on chromosome 23
(2016)Background Bovine tuberculosis (bTB) infection in cattle is a significant economic concern in many countries, with annual costs to the UK and Irish governments of approximately €190 million and €63 million, respectively, ... -
Genomic signals of migration and continuity in Britain before the Anglo-Saxons
(2016)The purported migrations that have formed the peoples of Britain have been the focus of generations of scholarly controversy. However, this has not benefited from direct analyses of ancient genomes. Here we report nine ...
