Genetics: Recent submissions

Now showing items 321-340 of 578

    • The N-end rule pathway regulates pathogen responses in plants. 

      WELLMER, FRANK (2016)
      To efficiently counteract pathogens, plants rely on a complex set of immune responses that are tightly regulated to allow the timely activation, appropriate duration and adequate amplitude of defense programs. The coordination ...

    • The role of Bcl-2 family in mitochondrial homeostasis 

      Carroll, Richard (Trinity College (Dublin, Ireland). Department of Genetics, 2015)
      Mitochondria are required by cells to generate ATP in order to meet their energy requirements. The electron transport chain, within the mitochondria, pumps protons into the intermembrane space generating an electrochemical ...

    • Genetic diagnosis and treatment of inherited retinopathies 

      Carrigan, Matthew (Trinity College (Dublin, Ireland). Department of Genetics, 2014)
      The first goal of this PhD was to improve and optimize a gene therapy based on the yeast protein Ndi 1 for Leber's Hereditary Optic Neuropathy (LHON), a mitochondrially-inherited retinal disorder. LHON is an incompletely ...

    • The role of Polycomb Repressive Complex 2 associated proteins in mediating complex recruitment 

      Brien, Gerard L. (Trinity College (Dublin, Ireland). Department of Genetics, 2013)
      All multi-cellular organisms are constructed from a myriad of distinct cell types, each performing specialized functions. With very few exceptions all cell types contain the same genetic information encoded in the genome. ...

    • Examination of transcriptional regulation and functional roles of axon guidance receptors in Drosophila dorsal vessel formation 

      Asadzadeh Tabrizi, Jamshid (Trinity College (Dublin, Ireland). Department of Genetics, 2014)
      Early steps of cardiogenesis in vertebrates and invertebrates are similar in that in both systems, bilateral rows of cardiac progenitors migrate towards a point where the two rows meet and make a tubular structure. As with ...

    • Enhancement of outflow facility in the murine eye by targeting selected tight-junctions of Schlemm's canal endothelia 

      HUMPHRIES, PETER; CAMPBELL, MATTHEW; HUMPHRIES, MARIAN (2017)
      The juxtacanalicular connective tissue of the trabecular meshwork together with inner wall endothelium of Schlemm’s canal (SC) provide the bulk of resistance to aqueous outflow from the anterior chamber. Endothelial cells ...

    • Panel-Based population next-generation sequencing for inherited retinal degenerations 

      Humphries, Peter; Farrar, Gwyneth (2016)
      Inherited retinopathies affect approximately two and a half million people globally, yet the majority of affected patients lack clear genetic diagnoses given the diverse range of genes and mutations implicated in these ...

    • On the development of molecular approaches to therapy for retinitis pigmentosa 

      Nguyen, Anh Thi Hong (Trinity College (Dublin, Ireland). Department of Genetics, 2013)
      Endothelial cells lining the microvasculature of the retina have highly evolved “tight junctions” reducing the space between adjacent cells to form a selective and highly regulatable barrier called the inner blood-retina ...

    • Modulation of the blood-brain barrier for therapeutic benefit 

      Hanrahan, Finnian (Trinity College (Dublin, Ireland). Department of Genetics, 2014)
      To date this lab has carried out novel work in the area of low-molecular weight (<1 kDa) drug delivery to the retina (Campbell, Nguyen et al. 2009; Tam, Kiang et al. 2010). This work was carried by suppression of claudin-5 ...

    • Transcriptional regulation by the ubiquitin system in model plant Arabidopsis thaliana 

      Hanczaryk, Katarzyna (Trinity College (Dublin, Ireland). Department of Genetics, 2014)
      In eukaryotes, the ubiquitin (Ub) system controls protein stability and regulates many developmental and physiological processes, in part through the regulation of transcription. Recent data show that some components of ...

    • Early farmers from across Europe directly descended from Neolithic Aegeans 

      Bradley, Daniel; Cassidy, Lara (2016)
      One of the most enduring and widely debated questions in prehistoric archaeology concerns the origins of Europe’s earliest farmers: Were they the descendants of local hunter-gatherers, or did they migrate from southwestern ...

    • Production of biologically active IL-36 family cytokines through insertion of N-terminal caspase cleavage motifs 

      MARTIN, SEAMUS (2016)
      Recent evidence has strongly implicated IL-36 cytokines as key initiators of inflammation in the skin barrier. IL-36 cytokines belong to the extended IL-1 family and, similar to most members of this family, are expressed ...

    • Neutrophil-Derived Proteases Escalate Inflammation through Activation of IL-36 Family Cytokines 

      MARTIN, SEAMUS (2016)
      IL-36 cytokines require proteolytic processing for activation, but how this is achieved is unknown. Here, Henry et al. show that proteases liberated from activated neutrophils—cathepsin G, elastase, and proteinase-3 ...

    • Explorations of miRNA expression in the mammalian retina 

      Loscher, Carol Jane (Trinity College (Dublin, Ireland). Department of Genetics, 2009)
      MicroRNAs (miRs) are an abundant class of non-coding RNAs which, for the most part were undiscovered until early this decade (Lagos-Quintana et al. 2001; Lee et al. 2001). Mature miR transcripts are small (~22 nucleotides) ...

    • Function and evolution of genes in the human protein interaction network 

      Pérez-Bercoff, Åsa (Trinity College (Dublin, Ireland). Department of Genetics, 2012)
      The research conducted for this thesis aims to elucidate how the human protein interaction network has evolved, and how protein interactions influence the spatial organisation of the metabolic network. The thesis presents ...

    • Evolution of vertebrate genome organisation 

      McLysaght, Aoife (Trinity College (Dublin, Ireland). Department of Genetics, 2002)
      The increasing availability of genomic sequences from different vertebrate organisms affords molecular biologists the opportunity to thoroughly investigate phenomena that were only hinted at by more sparse data. The work ...

    • Genetic investigation of Irish ancestry and surname history 

      McEvoy, Brian Patrick (Trinity College (Dublin, Ireland). Department of Genetics, 2005)
      Several genetic systems were employed in this study to investigate Ireland’s pre-history and history. Initially Irish origins were examined using mtDNA sequence variation in 200 new samples coupled with an extensive novel ...

    • Different patterns of gain and loss in genomic evolution 

      González Knowles, David (Trinity College (Dublin, Ireland). Department of Genetics, 2008)
      Evolutionary forces may act on the genome at different levels, from the change of single nucleotides to the duplication or rearrangement of whole chromosomes. Some of these evolutionary processes can be responsible for ...

    • Comparative analysis of poxvirus genome evolution 

      Bratke, Kirsten (Trinity College (Dublin, Ireland). Department of Genetics, 2010)
      In this thesis I examine the molecular evolution of poxviruses using various comparative genomics approaches. Poxviruses are large DNA viruses that infect vertebrates and insects. Understanding the evolutionary processes ...

    • Investigation of the immunophilin interactome of malarial parasites 

      Leneghan, Darren (Trinity College (Dublin, Ireland). Department of Genetics, 2014)
      Malaria presents a significant global challenge in both human and economic terms. Approximately 40% of the population of the planet are at risk of contracting malaria, leading to an estimated 225 million cases and ...