Genetics: Recent submissions
Now showing items 361-380 of 578
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Gene expression changes during retinal development and rod specification
(2015)Purpose: Retinitis pigmentosa (RP) typically results from individual mutations in any one of >70 genes that cause rod photoreceptor cells to degenerate prematurely, eventually resulting in blindness. Gene therapies ... -
Apoptosis gene profiling reveals spatio-temporal regulated expression of the p53/Mdm2 pathway during lens development.
(2009)Evidence is emerging for apoptosis gene expression in the lens during development. Therefore, here we used a filter array to assess expression of 243 apoptosis-related genes in the developing postnatal mouse lens using ... -
Gene expression profiles during early differentiation of mouse embryonic stem cells
(2009)Background Understanding the mechanisms controlling stem cell differentiation is the key to future advances in tissue and organ regeneration. Embryonic stem (ES) cell differentiation can be triggered by embryoid body ... -
Dynamics of chromatin accessibility and gene regulation by MADS-domain transcription factors in flower development.
(2014)Background Development of eukaryotic organisms is controlled by transcription factors that trigger specific and global changes in gene expression programs. In plants, MADS-domain transcription factors act as master ... -
GlycoRDF: An ontology to standardize glycomics data in RDF
(2015)Motivation: Over the last decades several glycomics-based bioinformatics resources and databases have been created and released to the public. Unfortunately, there is no common standard in the representation of the stored ... -
Comparison of BRCAx tumors with BRCA1-, BRCA2-carriers and non-familial breast cancer.
(2015)Aims Women with inherited pathogenic mutations in the BRCA1 or BRCA2 genes have up to an 85% risk of developing breast cancer in their lifetime. However, only about 20% of familial breast cancer is attributed to mutations ... -
Survival and innovation: The role of mutational robustness in evolution
(2014)Biological systems are resistant to perturbations caused by the environment and by the intrinsic noise of the system. Robustness to mutations is a particular aspect of robustness in which the phenotype is resistant to ... -
Transcriptomics: Unravelling the biology of transcription factors and chromatin remodelers during development and differentiation
(2009)The Polycomb group (PcG) proteins are transcriptional repressors that regulate lineage choices during development and differentiation. Recent studies have advanced our understanding of how the PcG proteins regulate cell ... -
Genetic evidence of African slavery at the beginning of the Trans-Atlantic slave trade
(2014)An archaeological excavation in Valle da Gafaria (Lagos, Portugal), revealed two contiguous burial places outside the medieval city walls, dating from the 15th-17th centuries AD: one was interpreted as a Leprosarium cemetery ... -
Paging through history: Parchment as a reservoir of ancient DNA for next generation sequencing
(2015)Parchment represents an invaluable cultural reservoir. Retrieving an additional layer of information from these abundant, dated livestock-skins via the use of ancient DNA (aDNA) sequencing has been mooted by a number of ... -
Microsatellite genotyping of medieval cattle from central Italy suggests an old origin of Chianina and Romagnola cattle
(2015)Analysis of DNA from archeological remains is a valuable tool to interpret the history of ancient animal populations. So far most studies of ancient DNA target mitochondrial DNA (mtDNA), which reveals maternal lineages, ... -
Variance components for susceptibility to Mycobacterium bovis infection in dairy and beef cattle
(2014)Open Access Research Variance components for susceptibility to Mycobacterium bovis infection in dairy and beef cattle Ian W Richardson12, Dan G Bradley1, Isabella M Higgins3, Simon J More3, Jennifer McClure4 and Donagh ... -
Definition of the cattle killer cell Ig-like receptor gene family: Comparison with aurochs and human counterparts
(2014)Under selection pressure from pathogens, variable NK cell receptors that recognize polymorphic MHC class I evolved convergently in different species of placental mammal. Unexpectedly, diversified killer cell Ig–like receptors ... -
A genome-wide association study for somatic cell score using the Illumina high-density bovine beadchip identifies several novel QTL potentially related to mastitis susceptibility
(2013)Mastitis is an inflammation-driven disease of the bovine mammary gland that occurs in response to physical damage or infection and is one of the most costly production-related diseases in the dairy industry worldwide. We ... -
Essential versus accessory aspects of cell death: recommendations of the NCCD 2015
(2014)Cells exposed to extreme physicochemical or mechanical stimuli die in an uncontrollable manner, as a result of their immediate structural breakdown. Such an unavoidable variant of cellular demise is generally referred to ... -
Autophagy in Multiple Myeloma: What Makes You Stronger Can Also Kill You.
(2013)Autophagy, a process for recycling cellular constituents, is normally associated with cell survival and is thought to be beneficial for tumor maintenance. However, in this issue of Cancer Cell, Lamy and colleagues report ... -
A perspective on mammalian caspases as positive and negative regulators of inflammation.
(2012)Members of the caspase family of cysteine proteases coordinate the morphological and biochemical events that typify apoptosis. However, neutralization of caspase activity in mammals fails to block death in response to ... -
Greasing the path to BAX/BAK activation
(2012)BAX/BAK activation leading to mitochondrial outer-membrane permeabilization is a key commitment point in apoptosis. Chipuk et al. now identify two sphingolipids as specific cofactors for BAX/BAK activation that lower the ... -
Staying alive: defensive strategies in the BCL-2 family playbook.
(2011)Much debate surrounds how prosurvival members of the BCL-2 family repress opening of the BAX/BAK channel to block apoptosis; in this issue Llambi et al. (2011) identify two modes of apoptosis inhibition that exhibit ... -
Oncogene-induced autophagy and the Goldilocks principle
(2011)Although several oncogenes enhance autophagic flux, the molecular mechanism and consequences of onco - gene-induced autophagy remain to be clarified. We have recently shown that expression of oncogenic H-Ras V12 ...
