Genetics: Recent submissions
Now showing items 381-400 of 578
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Oncogenic Ras-Induced Expression of Noxa and Beclin-1 Promotes Autophagic Cell Death and Limits Clonogenic Survival
(2011)Deregulated oncogenes such as MYC and RAS are typically insufficient to transform cells on their own due to the activation of pathways that restrain proliferation. Previous studies have shown that oncogenic H-Ras can induce ... -
Mitochondrial fusion : Bax to the Fussure
(2011)Mitochondria can be organized into highly interconnected networks through continuous cycles of fission and fusion. A recent study by Hoppins et al. (2011) published in Molecular Cell now suggests that Bax, more commonly ... -
A transcription factor network coordinates attraction, repulsion, and adhesion combinatorially to control motor axon pathway selection.
(2014)Combinations of transcription factors (TFs) instruct precise wiring patterns in the developing nervous system; however, how these factors impinge on surface molecules that control guidance decisions is poorly understood. ... -
A GATA/homeodomain transcriptional code regulates axon guidance through the Unc-5 receptor
(2012)Transcription factor codes play an essential role in neuronal specification and axonal guidance in both vertebrate and invertebrate organisms. However, how transcription codes regulate axon pathfinding remains poorly ... -
The homeodomain transcription factor Hb9 controls axon guidance in Drosophila through the regulation of Robo receptors.
(2014)Transcription factors establish neural diversity and wiring specificity; however, how they orchestrate changes in cell morphology remains poorly under- stood. The Drosophila Roundabout (Robo) receptors regulate ... -
Autosis: A new addition to the cell death tower of babel
(2014)Autophagy is a cellular recycling and stress response that degrades organelles and long-lived proteins and serves to protect cells from the potential damage induced by dysfunc- tional organelles and protein aggregates. ... -
An infection-relevant transcriptomic compendium for Salmonella enterica Serovar Typhimurium.
(2013)Bacterial transcriptional networks consist of hundreds of transcription factors and thousands of promoters. However, the true complexity of transcription in a bacterial pathogen and the effect of the environments encountered ... -
Inhibitor of Apoptosis Proteins (IAPs) and Their Antagonists Regulate Spontaneous and Tumor Necrosis Factor (TNF)-induced Proinflammatory Cytokine and Chemokine Production.
(2013)Inhibitor of apoptosis proteins (IAPs) play a major role in determining whether cells undergo apoptosis in response to TNF as well as other stimuli. However, TNF is also highly proinflammatory through its ability to trigger ... -
Parkin Sensitizes toward Apoptosis Induced by Mitochondrial Depolarization through Promoting Degradation of Mcl-1
(2014)Mitochondrial depolarization promotes Parkin- and PTEN-induced kinase 1 (PINK1)-dependent polyubiquitination of multiple proteins on mitochondrial outer membranes, resulting in the removal of defective mitochondria via ... -
Intravitreal delivery of AAV-NDI1 provides functional benefit in a murine model of Leber hereditary optic neuropathy.
(2013)Leber hereditary optic neuropathy (LHON) is a mitochondrially inherited form of visual dysfunction caused by mutations in several genes encoding subunits of the mitochondrial respiratory NADH-ubiquinone oxidoreductase ... -
Whole-transcriptome, high-throughput RNA sequence analysis of the bovine macrophage response to Mycobacterium bovis infection in vitro
(BioMed Central Ltd, 2013)Background Mycobacterium bovis, the causative agent of bovine tuberculosis, is an intracellular pathogen that can persist inside host macrophages during infection via a diverse range of mechanisms that subvert the host ... -
ChloroMitoSSRDB: open source repository of perfect and imperfect repeats in organelle genomes for evolutionary genomics.
(2013)Microsatellites or simple sequence repeats (SSRs) are repetitive stretches of nucleotides (A, T, G, C) that are distributed either as single base pair stretches or as a combination of two- to six-nucleotides units that are ... -
Genome-wide association study for calving traits in Holstein-Friesian dairy cattle
(2014)The enteropathogen Campylobacter jejuni is a major worldwide health and economic burden, being one of the leading causes of bacterial gastroenteritis and commonly linked to postinfectious onset of autoimmune disease. ... -
Coevolution analyses illuminate the dependencies between amino acid sites in the chaperonin system GroES-L.
(2013)BACKGROUND: GroESL is a heat-shock protein ubiquitous in bacteria and eukaryotic organelles. This evolutionarily conserved protein is involved in the folding of a wide variety of other proteins in the cytosol, being ... -
MDMA "ecstasy' increases cerebral cortical perfusion determined by bolus-tracking arterial spin labelling (btASL) MRI
(2013)BACKGROUND AND PURPOSE: The purpose of this study was to assess cerebral perfusion changes following systemic administration of the recreational drug 3,4-methylendioxymethamphetamine (MDMA 'ecstasy') to rats. EXPERIMENTAL ... -
PRMT4 Is a Novel Coactivator of c-Myb-Dependent Transcription in Haematopoietic Cell Lines
(2013)Protein arginine methyltransferase 4 (PRMT4)–dependent methylation of arginine residues in histones and other chromatin- associated proteins plays an important role in the regulation of gene expression. However, the exact ... -
CHD5 is required for neurogenesis and has a dual role in facilitating gene expression and polycomb gene repression
(2013)The chromatin remodeler CHD5 is expressed in neu- ral tissue and is frequently deleted in aggressive neuroblastoma.Verylittleisknownaboutthefunction of CHD5 in the nervous system or its mechanism of action. Here we ... -
A "Complex" Issue: Deciphering the Role of Variant PRC1 in ESCs.
(2013)Several noncanonical type-1 Polycomb Repressive Complexes (PRC1) that act independently of PRC2 have been recently identified, but their functions in embryonic stem cells (ESCs) are unclear. Two recent reports by Morey et ...
