Genetics: Recent submissions
Now showing items 461-480 of 578
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Evolution of Vertebrate Tissues Driven by Differential Modes of Gene Duplication.
(2012)In this study, we investigated the evolution of vertebrate tissues by examining the potential association among gene expression, duplication, and base substitution patterns. In particular, we compared whole-genome duplication ... -
Novel SNP Discovery in African Buffalo, Syncerus caffer, Using High-Throughput Sequencing
(2012)The African buffalo, Synceruscaffer , is one of the most abundant and ecologically important species of megafauna in the savannah ecosystem. It is an important prey species, as well as a host for a vast array of nematodes, ... -
Runs of homozygosity and population history in cattle
(2012)Background: Runs of homozygosity (ROH) are contiguous lengths of homozygous genotypes that are present in an individual due to parents transmitting identical haplotypes to their offspring. The extent and frequency of ROHs ... -
Mitochondrial disorders: aetiologies, models systems, and candidate therapies
(2013)It has become evident that many human disorders are characterised by mitochondrial dysfunction either at a primary level, due to mutations in genes whose encoded products are involved in oxidative phosphorylation, or at a ... -
Efficacy of codelivery of dual AAV2/5 vectors in the murine retina and hippocampus
(2012)Recombinant adeno-associated virus (AAV) represents an efficient system for neuronal transduction. However, a potential drawback of AAV is its restricted packaging capacity of approximately 5kb. To bypass this limita- tion, ... -
Systemic low-molecular weight drug delivery to pre-selected neuronal regions
(2011)We describe a procedure for controlled, periodic, reversible modulation of selected regions of the blood-brain barrier (BBB) or the inner-blood-retina barrier (iBRB) based on incorporation into an AAV-2/9 vector of a ... -
Evolutionary erosion of yeast sex chromosomes by mating-type switching accidents
(National Academy of Sciences, 2011)We investigate yeast sex chromosome evolution by comparing genome sequences from 16 species in the family Saccharomycetaceae, including data from genera Tetrapisispora, Kazachstania, Naumovozyma, and Torulaspora. We show ... -
Functional Diversification of the Twin-Arginine Translocation Pathway Mediates the Emergence of Novel Ecological Adaptations
(2011)Microorganisms occupy a myriad of ecological niches that show an astonishing diversity. The molecular mechanisms underlying microbes? ecological diversity remain a fundamental conundrum in evolutionary biology. Evidence ... -
Genome-wide Mapping of Polycomb Target Genes Unravels Their Roles in Cell Fate Transitions.
(2006)The Polycomb group (PcG) proteins form chromatin-modifying complexes that are essential for embryonic development and stem cell renewal and are commonly deregulated in cancer. Here, we identify their target genes using ... -
Characterization of E2F8, a novel E2F-like cell-cycle regulated repressor of E2F-activated transcription
(2005)The E2F family of transcription factors are downstream effectors of the retinoblastoma protein, pRB, pathway and are essential for the timely regulation of genes necessary for cell-cycle progression. Here we describe the ... -
Genome-wide analysis of gene expression during early Arabidopsis flower development
(Public Library of Science, 2006)Detailed information about stage-specific changes in gene expression is crucial for the understanding of the gene regulatory networks underlying development. Here, we describe the global gene expression dynamics during ... -
Global Gene Expression and Systems Biology Analysis of Bovine Monocyte-Derived Macrophages in Response to In Vitro Challenge with Mycobacterium bovis
(2012)BACKGROUND: Mycobacterium bovis, the causative agent of bovine tuberculosis, is a major cause of mortality in global cattle populations. Macrophages are among the first cell types to encounter M. bovis following exposure ... -
A Genome Wide Association Scan of Bovine Tuberculosis Susceptibility in Holstein-Friesian Dairy Cattle
(2012)BACKGROUND: Bovine tuberculosis is a significant veterinary and financial problem in many parts of the world. Although many factors influence infection and progression of the disease, there is a host genetic component and ... -
CARDINAL, a novel caspase recruitment domain protein, is an inhibitor of multiple NF-kappa B activation pathways.
(2001)Proteins possessing the caspase recruitment domain (CARD) motif have been implicated in pathways leading to activation of caspases or NF-kappaB in the context of apoptosis or inflammation, respectively. Here we report the ... -
Apoptosis-associated release of Smac/DIABLO from mitochondria requires active caspases and is blocked by Bcl-2
(2001)Smac/DIABLO is a mitochondrial protein that potentiates some forms of apoptosis, possibly by neutralizing one or more members of the IAP family of apoptosis inhibitory proteins. Smac has been shown to exit mitochondria and ... -
Smac/Diablo antagonizes ubiquitin ligase activity of inhibitor of apoptosis proteins
(2004)Inhibitor of apoptosis proteins (IAPs) can block apoptosis through binding to active caspases and antagonizing their function. IAP function can be neutralized by Smac/Diablo, an IAP-binding protein that is released from ... -
Interchain proteolysis, in the absence of a dimerization stimulus, can initiate apoptosis-associated caspase-8 activation
(2004)Caspases coordinate the internal demolition of the cell that is seen during apoptosis. Proteolytic processing of caspases is observed during apoptosis, and this correlates with conversion of inactive caspase proenzymes ... -
Caspase-dependent inactivation of proteasome function during programmed cell death in Drosophila and man
(The American Society for Biochemistry and Molecular Biology, 2004)The caspase family of cysteine proteases plays a conserved role in the coordinate demolition of cellular structures during programmed cell death from nematodes to man. Because cells undergoing programmed cell death in ... -
Bacterial L-forms on tap: an improved methodology to generate Bacillus subtilis L-forms heralds a new era of research
(2012)Bacterial L-forms are cell wall-less forms of bacteria that usually grow with a conventional cell wall. Despite being important for research, L-forms are difficult to generate reproducibly and research in this area is ... -
Rethinking the genetic architecture of schizophrenia
(Cambridge University Press, 2011)Background. For many years, the prevailing paradigm has stated that in each individual with schizophrenia (SZ) the genetic risk is due to a combination of many genetic variants, individually of small effect. Recent empirical ...
