Genetics: Recent submissions
Now showing items 441-460 of 578
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Polycomb group proteins: navigators of lineage pathways led astray in cancer
(2009)The Polycomb group (PcG) proteins are transcriptional repressors that regulate lineage choices during development and differentiation. Recent studies have advanced our understanding of how the PcG proteins regulate cell ... -
Further notes on the genealogy and social history of the Carlow family of John Tyndall (1820-1893)
(2013)Using local information and early correspondence we trace aspects of the history of the Carlow family of John Tyndall, concentrating particularly on his sister Emma and several hitherto unknown incidents in her life and ... -
Two forgotten poems by John Tyndall (1841)
(2013)Two poems published by John Tyndall (under the pseudonym "W.S.") in 1841 in his local newspaper The Carlow Sentinel are presented and their historical context revealed. The poems are of a political nature and intended to ... -
In silico identification of functional divergence between the multiple groEL gene paralogs in Chlamydiae
(2007)Background Heat-shock proteins are specialized molecules performing different and essential roles in the cell including protein degradation, folding and trafficking. GroEL is a 60 Kda heat-shock protein ubiquitous in ... -
Computational Biology Methods and Their Application to the Comparative Genomics of Endocellular Symbiotic Bacteria of Insects
(2009)Comparative genomics has become a real tantalizing challenge in the postgenomic era. This fact has been mostly magnified by the plethora of new genomes becoming available in a daily bases. The overwhelming list of new ... -
Genome-Wide Functional Divergence after the Symbiosis of Proteobacteria with Insects Unraveled through a Novel Computational Approach
(2009)Symbiosis has been among the most important evolutionary steps to generate biological complexity. The establishment of symbiosis required an intimate metabolic link between biological systems with different complexity ... -
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Proteome-Wide Analysis of Functional Divergence in Bacteria: Exploring a Host of Ecological Adaptations
(2012)Functional divergence is the process by which new genes and functions originate through the modification of existing ones. Both genetic and environmental factors influence the evolution of new functions, including gene ... -
Why should we care about molecular coevolution?
(2008)Abstract: Non-independent evolution of amino acid sites has become a noticeable limitation of most methods aimed at identifying selective constraints at functionally important amino acid sites or protein regions. The ... -
Molecular evolution of rbcL in three gymnosperm families: Identifying adaptive and coevolutionary patterns
(2011)Background: The chloroplast-localized ribulose-1, 5-biphosphate carboxylase/oxygenase (Rubisco), the primary enzyme responsible for autotrophy, is instrumental in the continual adaptation of plants to variations in ... -
Describing the structural robustness landscape of bacterial small RNAs
(2012)Background: The potential role of RNA molecules as gene expression regulators has led to a new perspective on the intracellular control and genome organization. Because secondary structures are crucial for their regulatory ... -
Molecular evolution of psbA gene in ferns: Unraveling selective pressure and co-evolutionary pattern
(2012)Abstract Background: The photosynthetic oxygen-evolving photo system II (PS II) produces almost the entire oxygen in the atmosphere. This unique biochemical system comprises a functional core complex that is encoded ... -
Evolutionary rate and duplicability in the Arabidopsis thaliana protein-protein interaction network
(2012)Genes show a bewildering variation in their patterns of molecular ev olution, as a result of the action of different levels and types of selective forces. The factors underlying this variation are, however, s till poorly ... -
The Roles of Whole-Genome and Small-Scale Duplications in the Functional Specialization of Saccharomyces cerevisiae Genes
(2013)Researchers have long been enthralled with the idea that gene duplication can generate novel functions, crediting this process with great evolutionary importance. Empirical data shows that whole-genome duplications (WGDs) ... -
The natural history review (1854-1865)
(2012)ABSTRACT: The natural history review was a quarterly founded in 1854 by Edward Perceval Wright, then an undergraduate student of zoology at Trinity College Dublin. Its first editorial committee (1856? 1860) held traditional ... -
Genome-wide associations for milk production and somatic cell score in Holstein-Friesian cattle in Ireland
(2012)Background: Contemporary dairy breeding goals have broadened to include, along with milk production traits, a number of non-production-related traits in an effort to improve the overall functionality of the dairy cow. ... -
Spatial trends of genetic variation of domestic ruminants in Europe
(2010)The introduction of livestock species in Europe has been followed by various genetic events, which created a complex spatial pattern of genetic differentiation. Spatial principal component (sPCA) analysis and spatial metric ... -
A complete mitochondrial genome sequence from a mesolithic wild aurochs (Bos primigenius)
(2010)ackground: The derivation of domestic cattle from the extinct wild aurochs ( Bos primigenius ) has been well-documented by archaeological and genetic studies. Genetic studies point towards the Neolithic Near East as ... -
Mammalian X chromosome inactivation evolved as a dosage-compensation mechanism for dosage-sensitive genes on the X chromosome.
(2012)How and why female somatic X-chromosome inactivation (XCI) evolved in mammals remains poorly understood. Ohno proposed a two-step process where XCI is a dosage-compensation mechaQ: 7 nism that evolved to equalize ... -
De novo origin of protein-coding genes in murine rodents.
(2012)Background: New genes in eukaryotes are created through a variety of different mechanisms. De novo origin from non-coding DNA is a mechanism that has recently gained attention. So far, de novo genes have been described in ...
