Neuroinflammation and disruptions in the integrity of neuronal circuitry are hallmarks of a range of CNS disorders. There is extensive evidence linking pro-inflammatory signalling and glial dysfunction with neuronal atrophy ...

A rich archive of oral and ethnological literature is housed in the National Folklore Collection, in University College Dublin, Ireland. The Schools’ Manuscript Collection is one body of information that contains a wealth ...

The crystallization of poorly soluble drug molecules with an excipient into new solid phases called cocrystals has gained a considerable popularity in the pharmaceutical field. In this work, the cocrystal approach was ...

The development of oral solid dosage forms, such as tablets that contain a high dose of drug(s), requires polymers and other additives to be incorporated at low levels as possible, to keep the final tablet weight low, and, ...

Kynurenine is a metabolite of the amino acid tryptophan by the action of the tryptophan dioxygenase enzyme in the liver and the ubiquitous indolamine dioxygenase enzyme in other tissues. Although it has been shown that ...