Pharmacy and Pharmaceutical Sciences: Recent submissions
Now showing items 101-120 of 622
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A Unique Polysaccharide containing 3-O-Methylarabinose and 3-O-Methylgalactose from Tinospora sinensis
(2018)Tinospora sinensis (Lour.) Merrill is of great therapeutic significance in Indian traditional medicine. Crude polysaccharides were isolated from methanol pre-extracted stems of dried material by successive extractions with ... -
Phytochemicals from food plant residues an approach to environmental clean-up.
(2011)Increased consumption of ‘ready to eat’ foods in modern lifestyle has resulted in several health problems. Natural health-protective and disease-preventive products are in great demand nowadays due to both consumers’ ... -
Experiences of the Medication Use Process by People with Intellectual Disabilities. What a Pharmacist Should Know!
(2021)There is a scarcity of information about the experience of people with intellectual disabilities in the medication use process. Six people with intellectual disabilities consented to be interviewed by a pharmacist to ... -
Defensive Pharmacy Practice: A Gap in our Understanding
(2021)Defensive practice is prevalent across healthcare disciplines and much study has been performed on this behaviour in medicine and nursing. However, little research has been carried out on defensive practice in pharmacy, ... -
A call for the standardised reporting of factors affecting the exogenous loading of extracellular vesicles with therapeutic cargos
(2021)Extracellular vesicles (EVs) are complex nanoparticles required for the intercellular transfer of diverse biological cargoes. Unlike synthetic nanoparticles, EVs may provide a natural platform for the enhanced targeting ... -
Biocompatible copolymer formulations to treat glioblastoma multiforme.
(2021)The treatment for glioblastoma multiforme (GBM) has not changed for more than 20 years while the prognosis for the patients is still poor and most of them survive less than 1 year after diagnosis. The standard of care for ... -
Medication Safety in Polypharmacy
(World Health Organisation, 2019)Ensuring medication safety in polypharmacy is one of the key challenges for medication safety today. Due to the traditional focus of both medical research and health care delivery models on single-disease interventions, ... -
Medication Safety in High-Risk Situations
(World Health Organisation, 2019)Each country participating in the third WHO Global Patient Safety Challenge: Medication Without Harm is urged to take early priority action to improve medication safety in high-risk situations and reduce harm by (5): ... -
Extracellular vesicles in blood: are they viable as diagnostic and predictive tools in breast cancer?
(2020)Extracellular vesicles (EVs), often described as mini-maps of their cells of origin, are found in the bloodstream and can be rich sources of cargo released from cancer cells. As such, they could be collected through minimally ... -
Extracellular vesicles report on the MET status of their cells of origin regardless of the method used for their isolation.
(2020)MET pathway is an important actionable target across many solid tumour types and several MET inhibitors have been developed. Extracellular vesicles (EVs) are proposed to be mini-maps of their cells of origin. However, the ... -
COVID-19: Is There Evidence for the Use of Herbal Medicines as Adjuvant Symptomatic Therapy?
(2020)Background: Current recommendations for the self-management of SARS-Cov-2 disease (COVID-19) include self-isolation, rest, hydration, and the use of NSAID in case of high fever only. It is expected that many patients will ... -
Carbohydrate-based Trojan microparticles as carriers for pulmonary delivery of lipid nanocapsules using dry powder inhalation
(2020)This study proposes lipid nanocapsules (LNCs)-based Trojan particles made by entrapping 59 ± 3 nm LNCs in carbohydrate-based microparticles via spray drying. This work focused on optimisation of maintenance of the nanocarrier ... -
Mechanochemical activation with cyclodextrins followed by compaction as an effective approach to improving dissolution of rutin
(2020)Rutin is one of the most important flavonoids with poor bioavailability. This work aimed at addressing the issue of poor biopharmaceutical performance of rutin by applying a combination of complexation with secondary ... -
Crystallo-co-spray drying as a new approach to manufacturing of drug/excipient agglomerates: impact of processing on the properties of paracetamol and lactose mixtures.
(2020)The novel process of crystallo-co-spray drying of paracetamol and α-lactose monohydrate was investigated by varying the spray dryer inlet temperature and inlet feed solvent composition. A crystalline agglomerate was obtained ... -
Physicochemical Characterization of a Co-Amorphous Atorvastatin-Irbesartan System with a Potential Application in Fixed-Dose Combination Therapy
(2021)The aim of this study was to characterize a 1:1 molar ratio of a pharmacologically relevant co-amorphous atorvastatin-irbesartan (ATR-IRB) system obtained by quench cooling of the crystalline ATR/IRB physical mixture for ... -
Green Synthesis of Lidocaine Ionic Liquids and Salts: Mechanisms of Formation and Interactions in the Crystalline and Supercooled States
(2020)Mechanochemistry has been recognized as an optimal route for the synthesis of ionic liquids incorporating active pharmaceutical ingredients (API-ILs) as it eliminates the need for large volumes of solvents and purification ... -
Development of new pharmacological agents for the treatment of T cell diseases of the skin
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2020) -
Discovery of therapies for lymphomas and leukaemia: Synthesis and antiproliferative action of novel ethanoanthracenes
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2021)Cancer is a broad class of diseases responsible for up to 9.6 million deaths worldwide in 2018, accountable for approximately every one in six deaths globally. Cancer is second only in all-cause mortality to circulatory ... -
Provision of clinical pharmacy services during the COVID-19 pandemic: experiences of pharmacists from 16 European countries
(2020)Background: The pharmacy profession has an important role in the frontline healthcare response to COVID-19 across all settings. Objective: This study sought to explore the views and experiences of clinical pharmacists in ... -
Primary Health Care and Community Pharmacy in Ireland: a lot of visions but little progress
(2020)Ireland is small country with a population of 4.8M which spent 6.9% of its gross domestic product on healthcare in 2018. Health services are provided through a twin track approach –all public services ...
