Pharmacy and Pharmaceutical Sciences: Recent submissions
Now showing items 561-580 of 622
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Design template for a medication safety programme in an acute teaching hospital
(2012)Background: Very limited data have been published about the design of medication safety programmes in hospitals. Objective: To describe a template for the structure and operation of a medication safety programme in an ... -
Profiling harmful medication errors in an acute Irish teaching hospital.
(2012)Background: Medication error reporting systems in hospitals are faced with the challenge of processing vast numbers of reports which identify a myriad of safety issues. With such large volumes of data and limited resources ... -
Single oral dose study of two isosorbide-based aspirin prodrugs in the dog
(2003)The objective of this study was to compare two aspirin prodrugs, isosorbide diaspirinate (ISDA) and a nitroaspirin (ISMNA), with aspirin in terms of effects on dog platelet function after administration of a single oral ... -
A comparison of community pharmacy methadone services between Dublin and Glasgow: (1) Extent of service provision in 1997/8 and views of pharmacists on existing provision and future service developments.
(2004)Objectives: To determine the extent of pharmacists' participation in methadone services, type of services provided, views on current service provision and suggestions for future service developments. Methods and setting: ... -
N1-dansyl-spermine: a potent polyamine antagonist.
(2004)The potential polyamine antagonist action of N1-dansyl-spermine (a potent NMDA antagonist) was assessed in two in vivo mouse models of polyamine action. Co-administration of N1-dansyl-spermine (2?10 ?g, i.c.v.) with spermine ... -
Pharmacological effects of a novel isosorbide-based butyrylcholinesterase inhibitor
(2008)Isosorbide-2-benzylcarbamate-5-benzoate, a novel butyrylcholinesterase inhibitor, shows interspecies variation in its inhibitory activity (IC50 of 4.3 nM for human plasma butyrylcholinesterase, but 1.09 ?M for mouse plasma ... -
Novel isosorbide di-ester compounds as inhibitors of acetylcholinesterase
(2008)We report herein that a variety of isosorbide di-esters, previously reported to be novel substrates for butyrylcholinesterase (BuChE, EC 3.1.1.8), are in fact inhibitors of the homologous enzyme acetylcholinesterase (AChE), ... -
Isosorbide-based cholinesterase inhibitors; replacement of 5-ester groups leading to increased stability
(2010)Isosorbide-2-carbamate-5-esters are highly potent and selective butyrylcholinesterase inhibitors with potential utility in the treatment of Alzheimer?s Disease (AD). They are stable in human plasma but in mouse plasma they ... -
Measuring and benchmarking safety culture: application of the safety attitudes questionnaire to an acute medical admissions unit.
(2009)Objectives: To assess the safety culture in an acute medical admissions unit (AMAU) of a teaching hospital in order to benchmark results against international data and guide a unit-based, integrated, risk management ... -
The interrelation of Physicochemical Parameters and Topological Descriptors for a series of O-blocking Agents
(American Chemical Society, 2002)The intercorrelation between a series of physicochemical parameters and topological indices for a set of a-blockers is investigated. Partition coefficients are calculated using the ClogP program, and the results are compared ... -
Cytoskeletal re-arrangement in TGF-beta1-induced alveolar epithelial-mesenchymal transition studied by atomic force microscopy and high-content analysis
(2012)Epithelial-mesenchymal transition (EMT) is closely implicated in the pathogenesis of idiopathic pulmonary fibrosis. Associated with this phenotypic transition is acquisition of an elongated cell morphology and establishment ... -
Approaches to the safety assessment of engineered nanomaterials (ENM) in food
(Elsevier, 2011)A systematic, tiered approach to assess the safety of engineered nanomaterials (ENMs) in foods is presented. The ENM is first compared to its non-nano form counterpart to determine if ENM-specific assessment is required. ... -
In-vivo impact of prodrug isosorbide-5-nicotinate-2-aspirinate on lipids and prostaglandin D2: is this a new immediate-release therapeutic option for niacin?
(2012)Objectives: To evaluate the pharmacokinetics and effects of the first immediate-release (IR) niacin-aspirin prodrug (ST0702) on lipid, prostaglandin and thromboxane levels in non-human primates (NHPs). Methods: We ... -
The potential of metabolic fingerprinting as a tool for the modernisation of TCM preparations
(2012)A vast majority Chinese Herbal Medicines (CHM) are traditionally administered as individually prepared water decoctions (tang) which are rather complicated in practice and their dry extracts show technological problems ... -
Transport of the fluorescent organic cation 4-(4-(dimethylamino)styryl)-N-methylpyridinium iodide (ASP+) in human respiratory epithelial cells
(2012)Organic cation/carnitine transporters (OCT/N) mediate uptake of positively charged molecules. Their role in lung epithelium, however, is not well understood. OCT/N expression and activity was studied in cell lines of human ... -
Mechanisms of aggregation inhibition by aspirin and nitrate-aspirin prodrugs in human platelets
(2012)OBJECTIVES: Aspirin is the mainstay of anti-platelet therapy in the secondary prevention of cardiovascular disease. However, problems with aspirin safety and resistance demand clinical strategies based on multiple ...
