Surgery (Theses and Dissertations): Recent submissions
Now showing items 21-40 of 54
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Examining the Radiation-induced Bystander Effect (RIBE) and its Effect on Metabolism and Inflammation in Gastrointestinal Cancers
(Trinity College Dublin. School of Medicine. Discipline of Surgery, 2021)Radiation therapy is a mainstay of treatment for cancer. However, resistance to therapy remains a major clinical problem in rectal and oesophageal cancer, with at best only 27-30% of patients achieving a complete pathological ... -
3D Bioprinting of Anatomically Accurate Implants for Meniscus Tissue Engineering
(Trinity College Dublin. School of Medicine. Discipline of Surgery, 2020)Menisci are soft tissues essential for load bearing and stress distribution in the knee joint. Meniscal injuries are common in all age groups and can lead to degeneration of the joint. While currently available surgical ... -
Investigating the impact of body composition and nutritional intervention strategies in pancreatic cancer
(Trinity College Dublin. School of Medicine. Discipline of Surgery, 2020)Introduction: Pancreatic adenocarcinoma (PDAC), while often described a rare or neglected cancer, is the fourth cause of cancer-related mortality in the US and Europe. Unintentional weight loss is a prominent feature of ... -
Oesophageal cancer : association with visceral obesity, inflammation and optimisation of postoperative outcomes
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2013)The incidence of oesophageal cancer is rising in the developed world and has paralleled the rising prevalence of obesity. This is an aggressive malignancy with poor overall survival rates. Thus there is an impetus to ... -
Enhancing treatment response to neo-adjuvant radiation therapy in oesophageal cancer using novel dual action drugs targeting tumour energy metabolism and angiogenesis
(Trinity College Dublin. School of Medicine. Discipline of Surgery, 2019)Oesophageal cancer is an aggressive malignancy associated with a poor 5-year survival of <20%, accounting for over 400,000 deaths each year. The current standard of care for oesophageal adenocarcinoma (OAC) ... -
Investigation of the molecular mechanisms underlying radioresistance in oesophageal cancer
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2011)The current standard of care for oesophageal cancer in Ireland involves neoadjuvant chemoradiation therapy (CRT) followed by surgery. Despite advances in treatment, resistance to neoadjuvant CRT remains a significant ... -
The Epidemiological, Clinical and Genetic Aspects of Chronic Pancreatitis in Ireland
(Trinity College Dublin. School of Medicine. Discipline of Surgery, 2018)Abstract: The epidemiological, clinical and genetic aspects of chronic pancreatitis in Ireland - Hazel Maria Ní Chonchubhair. Introduction: Chronic pancreatitis is a progressive, inflammatory, malabsorptive disease of the ... -
Investigation into mitochondrial function and energy metabolism and their connectivity with protumourigenic cellular proceses in Barrett's oesophagus
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2016)Contemporary clinical management of Barrett’s oesophagus has highlighted the lack of accurate predictors of neoplastic progression. Currently all Barrett’s patients undergo surveillance, however, only a subset of patients ... -
Continuous Vagal Intraoperative Monitoring Prevents Recurrent Laryngeal Nerve Paralysis by Revealing Initial EMG Changes of Impending Neuropraxic Injury
The larynx is the phonating mechanism, specifically designed for voice production. Through movement of the cartilages, the larynx varies the opening between the vocal cords and thereby varies the pitch of sounds produced ... -
Expanding the role of positron emission tomography-computed tomography and its utility in the management of oesophageal cancer
(Trinity College Dublin. School of Medicine. Discipline of Surgery, 2018)Purpose: 18F-fluorodeoxyglucose positron emission tomography and computed tomography (18F-FDG PET-CT) is an established diagnostic tool in the management of oesophageal cancer. The role of 18F-FDG PET-CT in assessing tumour ... -
Molecular analysis of cell proliferation and apoptosis in oesophageal adenocarcinoma
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2002)Cancer of the oesophagus is a particularly virulent gastrointestinal malignancy with poor prognosis. Replacement of the nomial squamous epithelium of the oesophagus with columnar epithelium (Barrett’s oesophagus) as a ... -
The immunomodulatory chemokine CCL28 in oesophageal disease progression
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2014)Barrett’s oesophagus (BO) develops in response to bile acid reflux and confers increased risk of progression to oesophageal adenocarcinoma (OAC). During this disease progression, the immune microenvironment of the oesophageal ... -
Mitochondrial dysfunction during disease progression in Barrett's oesophagus
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2014)Barrett’s oesophagus is the leading risk factor for oesophageal adenocarcinoma. However, it is difficult to identify patients at risk of disease progression. Mitochondria are highly susceptible to mutations due to high ... -
Mechanisms linking obesity, genomic instability and the radioresponse in oesophageal adenocarcinoma
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2014)The increasing incidence of oesophageal adenocarcinoma (OAC) parallels the rapidly rising incidence of obesity. OAC is an exemplar model of obesity-associated cancer, with an increasing focus on the role of visceral adipose ... -
Gene expression profiling in patients with severe sepsis
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2014)The human response to infection ranges from mild illness which is relatively well tolerated to a severe, potentially life-threatening syndrome termed severe sepsis. This thesis explored this response in patients hospitalised ... -
Cytokine mRNA gene expression profiles in human host response to infection and sepis
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2013)This thesis explores the hypothesis that a cytokine mediated immune response modulates the human immune response to infection. Attenuation of this cytokine response may increase the risk of infection and sepsis in humans. -
The role of the cyclooxygenase-2 - prostaglandin E2 cascade in pancreatic cancer associated angiogenesis
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2010)Medical therapy has failed to make any significant impact on survival in pancreatic cancer. Non Steroidal Anti-inflammatory Drugs (NSAIDs) have shown promise in several gastrointestinal (Gl) cancers. Evidence has suggested ... -
Local and systemic inflammation in oesophageal disease
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2010)Background: Reflux-induced injury and oxidative stress result in oesophageal inflammation and the potential for progression to intestinal metaplasia and adenocarcinoma. Proton-pump inhibitors represent the standard medical ... -
Obesity and cancer
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2011)Cancer rates are increasing with predictions of incidence rates doubling between 2000 and 2020. Although several factors are contributory, the rising incidence of overweight and obesity is currently thought to be fuelling ... -
Molecular and radiological prediction of response to neo-adjuvant chemoradiation in patients with oesophageal cancer
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2009)The initial phase of the project’s laboratory component involved optimising techniques that would become necessary when analysing fresh oesophageal tissue. There are a number of commercially available techniques for tissue ...
