Surgery (Theses and Dissertations): Recent submissions
Now showing items 41-54 of 54
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Extending the limits of cardiovascular disease risk estimation : the roles of HDL cholesterol, resting heart rate and advancing years
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2010)Background: Atherosclerotic cardiovascular diseases (CVD) including coronary heart disease, stroke and peripheral vascular disease are the commonest causes of death Worldwide. The underlying atherosclerosis starts early ... -
Delineating the pro-carcinogenic pathways activated by obesity in Barrett's oesophagus
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2011)Incidences of obesity in the developed world represent a worrying epidemic. Obesity is associated with increased rates of diabetes, cardiovascular disease and cancer. Oesophageal adenocarcinoma rates have increased in the ... -
Investigation of the link between obesity and breast cancer - the role of adipose tissue in the development and propagation of malignancy
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2010)Obesity and the metabolic syndrome are emerging risk factors for breast cancer. They are associated with increased incidence, an increased recurrence rate and a poorer prognosis. Despite this epidemiological evidence to ... -
Oesophageal inflammation and tumourigenesis - inherited variation in an Irish population
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2010)Cancer is a major medical challenge of this era and early diagnosis of cancer is critical to curative therapy. The search for biomarkers that may indicate the risk or presence of cancer is ongoing in thousands of laboratories ... -
Molecular interactions in obesity and cancer
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2010)The incidence of overweight and obesity has reached pandemic proportions in modern society, affecting two thirds of the US and over half of the European population. Obesity is associated with increased morbidity and mortality ... -
Malnutrition, deficiency, and nutritional practice in patients with acute and chronic pancreatitis
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2014)Pancreatitis is an inflammatory disease of the pancreas and it may occur in either acute or chronic form, the former being life-threatening in its most severe form, and the latter being a progressive, irreversible disease ... -
Visceral adiposity and oesophageal adenocarcinoma : exploring the role of the insulin like-growth factor axis
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2012)In the modem era there is a consistent reported trend of markedly improved operative and oncologic outcomes from high-volume oesophageal programmes within academic medical centres. The current benchmark survival rate in ... -
Nutritional studies in upper gastrointestinal cancer
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2008)Carcinoma of the oesophagus, gastro-oesophageal junction and stomach represent aggressive diseases with a poor prognosis even in patients undergoing curative resection. Where squamous cell histology once predominated, the ... -
Gastro-oesophageal reflux disease : studies in physiology and innovations in surgical management
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2007)The work detailed in this thesis combined studies in surgical audit with assessment of outcomes relating to dysmotility, evaluated an innovative approach to quality assurance in surgery, explored new understandings of ... -
Predictors of response of rectal cancer to neoadjuvant radiochemotherapy
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2007)Rectal cancers staged as cT3/T4 +/- node positive routinely receive neoadjuvant radiochemotherapy (RCT) followed by total mesorectal excision (TME). By this approach tumours can be both downstaged and downsized resulting ... -
The effect of major surgery on systemic and splanchnic immune function : examining the two-hit and gut hypotheses of the systemic inflammatory response syndrome
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2006)The systemic inflammatory response syndrome (SIRS), sepsis and multiple organ dysfunction syndrome (MODS) are recognized sequelae of complex major surgery and underlie significant morbidity and mortality. The systemic ... -
Pelvic floor dysfunction : its assessment by MRI and strength duration test and its response to biofeedback
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2006)The component features of pelvic floor dysfunction (PFD) are interrelated but the development of a unified strategy to investigate and treat these problems has been slow; this has invariably affected the outcome of available ... -
Systemic inflammation after cardiac surgery
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2008)Genetically determined inter-individual variation in cytokine production, influences outcome in patients with systemic inflammation and severe sepsis. However outcome in patients with sepsis is also dependant on the presence ... -
Experimental reinforcement of the vertebral endplate : a biomechanical study on prevention of intervertebral cage subsidence
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2007)
